Stability and Structure of Protein–Lipoamino Acid Colloidal Particles: Toward Nasal Delivery of Pharmaceutically Active Proteins

International audienc

Automatic quantitative computed tomography measurement of longitudinal lung volume loss in interstitial lung diseases

International audienceAbstract Objectives To compare the lung CT volume (CT vol ) and pulmonary function tests in an interstitial lung disease (ILD) population. Then to evaluate the CT vol loss between idiopathic pulmonary fibrosis (IPF) and non-IPF and explore a prognostic value of annual CT vol loss in IPF. Methods We conducted in an expert center a retrospective study between 2005 and 2018 on consecutive patients with ILD. CT vol was measured automatically using commercial software based on a deep learning algorithm. In the first group, Spearman correlation coefficients ( r ) between forced vital capacity (FVC), total lung capacity (TLC), and CT vol were calculated. In a second group, annual CT vol loss was calculated using linear regression analysis and compared with the Mann–Whitney test. In a last group of IPF patients, annual CT vol loss was calculated between baseline and 1-year CTs for investigating with the Youden index a prognostic value of major adverse event at 3 years. Univariate and log-rank tests were calculated. Results In total, 560 patients (4610 CTs) were analyzed. For 1171 CTs, CT vol was correlated with FVC ( r : 0.86) and TLC ( r : 0.84) ( p < 0.0001). In 408 patients (3332 CT), median annual CT vol loss was 155.7 mL in IPF versus 50.7 mL in non-IPF ( p < 0.0001) over 5.03 years. In 73 IPF patients, a relative annual CT vol loss of 7.9% was associated with major adverse events (log-rank, p < 0.0001) in univariate analysis ( p < 0.001). Conclusions Automated lung CT volume may be an alternative or a complementary biomarker to pulmonary function tests for the assessment of lung volume loss in ILD. Key Points • There is a good correlation between lung CT volume and forced vital capacity, as well as for with total lung capacity measurements (r of 0.86 and 0.84 respectively, p < 0.0001). • Median annual CT volume loss is significantly higher in patients with idiopathic pulmonary fibrosis than in patients with other fibrotic interstitial lung diseases (155.7 versus 50.7 mL, p < 0.0001). • In idiopathic pulmonary fibrosis, a relative annual CT volume loss higher than 9.4% is associated with a significantly reduced mean survival time at 2.0 years versus 2.8 years (log-rank, p < 0.0001)