Selective Synthesis of Trimethylamine by Catalytic N -Methylation of Ammonia and Ammonium Chloride by utilizing Carbon Dioxide and Molecular Hydrogen

The synthesis of trimethylamine (TMA) through a multicomponent combination of ammonia with carbon dioxide and molecular hydrogen by using a homogeneous ruthenium catalyst was explored. The use of [Ru(triphos)(tmm)] [triphos: 1,1,1-tris(diphenylphosphinomethyl)ethane, tmm: trimethylene methane] together with aluminum trifluoromethanesulfonate as a co-catalyst resulted in high ammonia conversion and excellent selectivity for TMA in organic solvents. Aqueous solutions of ammonium chloride were methylated almost quantitatively to the corresponding hydrochloride salt (i.e., TMA⋅HCl) in a biphasic solvent system by using the same Ru complex without the need for any co-catalyst

Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial

International audienc

Endovascular thrombectomy for acute ischaemic stroke with established large infarct (TENSION): 12-month outcomes of a multicentre, open-label, randomised trial

International audienc