The impact of chronic illness: partnerships with other healthcare professionals

Healthcare workforce shortfalls require a rethinking of models for delivering care to people with chronic disease. Chronic disease needs to be managed by a multiskilled team of healthcare professionals with specialist input. Education at undergraduate, graduate and postgraduate levels needs to prepare healthcare professionals for this new paradigm. Some tasks currently seen only as part of a doctor's purview could be performed by other trained professionals to allow doctors to concentrate on more appropriate activities. We need to explore new collaborations to deliver multidisciplinary healthcare for chronic disease and evaluate these for patient outcomes and cost effectiveness

AGROFORESTRY POLICIES CONTRIBUTE TO SUSTAINABLE LAND USE

Resource /Energy Economics and Policy,

The tRNAscan-SE, snoscan and snoGPS web servers for the detection of tRNAs and snoRNAs

Transfer RNAs (tRNAs) and small nucleolar RNAs (snoRNAs) are two of the largest classes of non-protein-coding RNAs. Conventional gene finders that detect protein-coding genes do not find tRNA and snoRNA genes because they lack the codon structure and statistical signatures of protein-coding genes. Previously, we developed tRNAscan-SE, snoscan and snoGPS for the detection of tRNAs, methylation-guide snoRNAs and pseudouridylation-guide snoRNAs, respectively. tRNAscan-SE is routinely applied to completed genomes, resulting in the identification of thousands of tRNA genes. Snoscan has successfully detected methylation-guide snoRNAs in a variety of eukaryotes and archaea, and snoGPS has identified novel pseudouridylation-guide snoRNAs in yeast and mammals. Although these programs have been quite successful at RNA gene detection, their use has been limited by the need to install and configure the software packages on UNIX workstations. Here, we describe online implementations of these RNA detection tools that make these programs accessible to a wider range of research biologists. The tRNAscan-SE, snoscan and snoGPS servers are available at , and , respectively

Compositions and Methods for Treating Inflammation and Fibrosis

The present invention features compositions featuring agents that bind to denatured collagen and methods of using such agents to treat or prevent fibrosis or inflammation in a subject. CROSS-REFERENCE TO RELATED APPLICATION [0001] This application is a continuation of U.S. application Ser. No. 13/395,373 filed May 29, 2012, which is a U.S. national phase application of PCT/US2010/052642, filed Oct. 14, 2010, which claims the benefit of U.S. Provisional Application No. 61/253,211, filed Oct. 20, 2009, the entire contents of which are expressly incorporated herein by reference

Enhancing the Therapeutic Activity of an Immune Checkpoint Inhibitor

The present invention provides antagonists and methods of use thereof in the treatment of cancer and abnormal immune suppression disease

Managing Arthritis in the Bone and Joint Decade

The United Nations has endorsed a Bone and Joint Decade to focus attention on five specific musculoskeletal conditions - osteoarthritis, osteoporosis, musculoskeletal trauma, inflammatory arthritis and back pain. All conditions are common and chronic

Bone and Joint Diseases: Prevention and Control

Arthritis is Australia's major cause of disability and chronic pain. In Australian women, osteoarthritis is the third leading cause of years lost due to disability. Osteoporosis affects nearly two million Australians. The Federal government acknowledged the importance of musculoskeletal diseases by designating arthritis and musculoskeletal diseases as the seventh National Health Priority. This decade has been designated by the United Nations and the World Health Organization as the Decade of Bone and Joint Disease. To try to raise awareness, the National Action Network (the committee charged with organising activities in Australia) arranged a summit in 2002 to focus on preventive issues for osteoporosis and arthritis, and the benefits of surgical approaches