The present invention features compositions featuring agents that bind to denatured collagen and methods of using such agents to treat or prevent fibrosis or inflammation in a subject. CROSS-REFERENCE TO RELATED APPLICATION [0001] This application is a continuation of U.S. application Ser. No. 13/395,373 filed May 29, 2012, which is a U.S. national phase application of PCT/US2010/052642, filed Oct. 14, 2010, which claims the benefit of U.S. Provisional Application No. 61/253,211, filed Oct. 20, 2009, the entire contents of which are expressly incorporated herein by reference