Pandemic Pressure: Race, Job Insecurity, and Stress during the COVID-19 Pandemic

With the ongoing pressure of the COVID-19 pandemic, the working world has been drastically altered. Additionally, pandemic related pressures are not evenly distributed across racial groups–with negative outcomes being exacerbated as a byproduct of structural inequities for people of color (Seldan & Berdahl, 2020). Using the Perceived Stress Scale (Cohen et al., 1983), and Job Insecurity Scale (Ashford et al., 1989), we aimed to determine how various work-related factors such as job insecurity, essential worker status, and race relate to overall perceived stress in daily life. Participants (n = 266; Mage = 50.56 years, SD = 7.83; age range: 18-76 years; 49% white, 51% Black) completed a variety of measures through an online survey collected between mid-April and late May 2021. The results indicated that for white workers who identified as non-essential, and Black workers who identified as essential, increased job insecurity predicted an increase in perceived stress. The results of the study provide a launching point for identifying which demographic groups may need more support in the working world. Black essential workers and white non-essential workers likely would greatly benefit from support, resources, and interventions aiming to reduce workplace stress and improve wellbeing

Monkey hybrid stem cells develop cellular features of Huntington's disease

<p>Abstract</p> <p>Background</p> <p>Pluripotent stem cells that are capable of differentiating into different cell types and develop robust hallmark cellular features are useful tools for clarifying the impact of developmental events on neurodegenerative diseases such as Huntington's disease. Additionally, a Huntington's cell model that develops robust pathological features of Huntington's disease would be valuable for drug discovery research.</p> <p>Results</p> <p>To test this hypothesis, a pluripotent Huntington's disease monkey hybrid cell line (TrES1) was established from a tetraploid Huntington's disease monkey blastocyst generated by the fusion of transgenic Huntington's monkey skin fibroblast and a wild-type non-transgenic monkey oocyte. The TrES1 developed key Huntington's disease cellular pathological features that paralleled neural development. It expressed mutant huntingtin and stem cell markers, was capable of differentiating to neural cells, and developed teratoma in severely compromised immune deficient (SCID) mice. Interestingly, the expression of mutant htt, the accumulation of oligomeric mutant htt and the formation of intranuclear inclusions paralleled neural development <it>in vitro </it>, and even mutant htt was ubiquitously expressed. This suggests the development of Huntington's disease cellular features is influenced by neural developmental events.</p> <p>Conclusions</p> <p>Huntington's disease cellular features is influenced by neural developmental events. These results are the first to demonstrate that a pluripotent stem cell line is able to mimic Huntington's disease progression that parallels neural development, which could be a useful cell model for investigating the developmental impact on Huntington's disease pathogenesis.</p

Interferometric imaging of carbon monoxide in comet C/1995 O1 (Hale-Bopp): evidence for a strong rotating jet

Observations of the CO J(1-0) 115 GHz and J(2-1) 230 GHz lines in comet C/1995 O1 (Hale-Bopp) were performed with the IRAM Plateau de Bure interferometer on 11 March, 1997. The observations were conducted in both single-dish (ON-OFF) and interferometric modes with 0.13 km s-1 spectral resolution. Images of CO emission with 1.7 to 3" angular resolution were obtained. The ON-OFF and interferometric spectra show a velocity shift with sinusoidal time variations related to the Hale-Bopp nucleus rotation of 11.35 h. The peak position of the CO images moves perpendicularly to the spin axis direction in the plane of the sky. This suggests the presence of a CO jet, which is active night and day at about the same extent, and is spiralling with nucleus rotation. The high quality of the data allows us to constrain the characteristics of this CO jet. We have developed a 3-D model to interpret the temporal evolution of CO spectra and maps. The CO coma is represented as the combination of an isotropic distribution and a spiralling gas jet, both of nucleus origin. Spectra and visibilities (the direct output of interferometric data) analysis shows that the CO jet comprises ~40% the total CO production and is located at a latitude ~20 degrees North on the nucleus surface. Our inability to reproduce all observational characteristics shows that the real structure of the CO coma is more complex than assumed, especially in the first thousand kilometres from the nucleus. The presence of another moving CO structure, faint but compact and possibly created by an outburst, is identified.Comment: 20 pages, 26 figures. Accepted for publication in Astronomy & Astrophysic

Constraints on the χ_(c1) versus χ_(c2) polarizations in proton-proton collisions at √s = 8 TeV

The polarizations of promptly produced χ_(c1) and χ_(c2) mesons are studied using data collected by the CMS experiment at the LHC, in proton-proton collisions at √s=8  TeV. The χ_c states are reconstructed via their radiative decays χ_c → J/ψγ, with the photons being measured through conversions to e⁺e⁻, which allows the two states to be well resolved. The polarizations are measured in the helicity frame, through the analysis of the χ_(c2) to χ_(c1) yield ratio as a function of the polar or azimuthal angle of the positive muon emitted in the J/ψ → μ⁺μ⁻ decay, in three bins of J/ψ transverse momentum. While no differences are seen between the two states in terms of azimuthal decay angle distributions, they are observed to have significantly different polar anisotropies. The measurement favors a scenario where at least one of the two states is strongly polarized along the helicity quantization axis, in agreement with nonrelativistic quantum chromodynamics predictions. This is the first measurement of significantly polarized quarkonia produced at high transverse momentum