The Tensionless Limit of Pure-Ramond-Ramond AdS3/CFT2

Despite impressive advances in the AdS3/CFT2 correspondence, the setup involving Ramond-Ramond backgrounds, which is related to the D1-D5 system of branes, remained relatively poorly understood. We use the Mirror TBA equations recently constructed by Frolov and Sfondrini to study the spectrum of pure Ramond-Ramond $AdS_3\times S^3\times T^4$ strings. We find that the leading-order contribution to the anomalous dimensions at small tension is due to the gapless worldsheet excitations, i.e. to the $T^4$ bosons and their superpartners, whose interactions are nontrivial.Comment: 6 pages, 3 figure

More on the tensionless limit of pure-Ramond-Ramond AdS3/CFT2

In a recent letter we presented the equations which describe tensionless limit of the excited-state spectrum for strings on $AdS_3\times S^3\times T^4$ supported by Ramond-Ramond flux, and their numerical solution. In this paper, we give a detailed account of the derivation of these equations from the mirror TBA equations proposed by Frolov and Sfondrini, discussing the contour-deformation trick which we used to obtain excited-state equations and the tensionless limit. We also comment at length on the algorithm for the numerical solution of the equations in the tensionless limit, and present a number of explicit numerical results, as well as comment on their interpretation.Comment: 82 pages, many figures and table

Dopo la gentrificazione. Un quartiere laboratorio dalla crisi economica all'abitare temporaneo

Cosa c’è dopo la gentrificazione? Le scienze sociali hanno analizzato i processi di gentrificazione, ma cosa avviene in un quartiere quando essa entra in crisi e si arresta? Lo studio del quartiere romano di San Lorenzo ci permette di rispondere a questa domanda, che investe molte città italiane e, più in generale, dell’Europa mediterranea. La crisi economica scoppiata nel 2008 ha prodotto anche una crisi dell’urbano, che ha colpito in particolare le zone della città precedentemente «valorizzate». San Lorenzo non è solo un quartiere, ma il simbolo di una certa idea di città. È infatti il quartiere universitario della capitale, ma anche quello dei movimenti e della partecipazione politica. Un quartiere che, proprio a causa dei processi gentrificatori, si è svuotato di abitanti e poi di attività sociali. Un quartiere divenuto, come si legge negli annunci delle agenzie immobiliari, «a uso investimento», per cui la casa non è più collegata all’abitare stanziale ma a quello temporaneo

On the diagnosis of malignant pleural mesothelioma: A necropsy-based study of 171 cases (1997-2016)

Malignant pleural mesothelioma (MPM) diagnosis is known to be difficult. We report on the diagnostic elements available in life in an MPM necropsy case series and describe the frequency of non-neoplastic asbestos-related diseases as biological exposure indices

More on the tensionless limit of pure-Ramond-Ramond AdS3/CFT2

Abstract In a recent letter we presented the equations which describe tensionless limit of the excited-state spectrum for strings on AdS 3 × S 3 × T 4 supported by Ramond-Ramond flux, and their numerical solution. In this paper, we give a detailed account of the derivation of these equations from the mirror TBA equations proposed by Frolov and Sfondrini, discussing the contour-deformation trick which we used to obtain excited-state equations and the tensionless limit. We also comment at length on the algorithm for the numerical solution of the equations in the tensionless limit, and present a number of explicit numerical results, as well as comment on their interpretation

How to resume safe access to a medical simulation center at the time of COVID-19 pandemic: The proposal of a protocol from a university institution in North-Eastern Italy

INTRODUCTION: The Covid-19 global pandemic has suspended thousands of clinical education programs around the world. Also in Italy, as in the rest of the world, frontal teaching activities and internships in the medical field have been suspended. At the university hospital of Udine (North-Eastern Italy) it was decided to strengthen the use of simulation in all training stages to get over the block of training activities. METHODS: A protocol has been drawn up with the aim of providing training in safety for every student of the degree courses in medicine and health area and for doctors in residency training. In this way it was possible to carry out training sessions with a maximum of 6 students engaged in the simulation activities offered by the Center (3D) virtual cadaver, laparoscopic pelvic trainer stations, ultrasound laboratory, microsurgery, etc.). The key points of the protocol were represented by i) internet booking of the training activity; ii) respect of safety measures (hand hygiene, safe distance, restricted total number of presences, constant use of the surgical mask) and iii) reorganization of the material and cleaning of the rooms. RESULTS: Our educational strategy allowed to resume training activity maintaining adequate levels of safety for students and teachers. Applying our protocol, it was possible to guarantee safe access to our Medical Simulation Center (MSC) to a total of about 1400 students from different course of study during the period between June 2020 and February 2021. CONCLUSIONS: Our protocol could represent a practical tool in the management of resuming the activity at a MSC

A genetic variant of NLRP1 gene is associated with asbestos body burden in patients with malignant pleural mesothelioma.

The presence of asbestos bodies (ABs) in lung parenchyma is considered a histopathologic hallmark of past exposure to asbestos fibers, of which there was a population of longer fibers. The mechanisms underlying AB formation are complex, involving inflammatory responses and iron (Fe) metabolism. Thus, the responsiveness to AB formation is variable, with some individuals appearing to be poor AB formers. The aim of this study was to disclose the possible role of genetic variants of genes encoding inflammasome and iron metabolism proteins in the ability to form ABs in a population of 81 individuals from North East Italy, who died after having developed malignant pleural mesothelioma (MPM). This study included 86 genetic variants distributed in 10 genes involved in Fe metabolism and 7 genetic variants in two genes encoding for inflammasome molecules. Genotypes/haplotypes were compared according to the number of lung ABs. Data showed that the NLRP1 rs12150220 missense variant (H155L) was significantly correlated with numbers of ABs in MPM patients. Specifically, a low number of ABs was detected in individuals carrying the NLRP1 rs12150220 A/T genotype. Our findings suggest that the NLRP1 inflammasome might contribute in the development of lung ABs. It is postulated that the NLRP1 missense variant may be considered as one of the possible host genetic factors contributing to individual variability in coating efficiency, which needs to be taken when assessing occupational exposure to asbestos

Iron signature in asbestos-induced malignant pleural mesothelioma: A population-based autopsy study.

Malignant pleural mesothelioma (MPM) is an aggressive cancer with poor prognosis. The development of MPM is frequently linked to inhalation of asbestos fibers. A genetic component of susceptibility to this disease is suggested by the observation that some individuals develop MPM following lower doses of asbestos exposure, whereas others exposed to higher quantities do not seem to be affected. This hypothesis is supported also by frequent reports of MPM familial clustering. Despite the widely recognized role of iron (Fe) in cellular asbestos-induced pulmonary toxicity, the role of the related gene polymorphisms in the etiology of MPM has apparently not been evaluated. Eighty-six single-nucleotide polymorphisms (SNPs) of 10 Fe-metabolism genes were examined by exploiting formalin-fixed paraffin-embedded postmortem samples from 77 patients who died due to MPM (designated AEM) and compared with 48 who were exposed to asbestos but from died in old age of cause other than asbestos (designated AENM). All subjects showed objective signs of asbestos exposure. Three SNPs, localized in the ferritin heavy polypeptide, transferrin, and hephaestin genes, whose frequencies were distributed differently in AEM and AENM populations, were identified. For ferritin and transferrin the C/C and the G/G genotypes, respectively, representing intronic polymorphisms, were significantly associated with protection against MPM and need to be considered as possible genetic markers of protection. Similarly, the C/C hephaestin SNP, a missense variation of this multicopper ferroxidase encoding gene, may be related, also functionally, with protection against MPM. In conclusion, it is proposed that three Fe metabolism-associated genes, significantly associated with protection against development of MPM, may serve as protective markers for this aggressive tumor

Development and validation of SCOPE score: a clinical score to predict progression of COVID-19 pneumonia to severe respiratory failure

Most patients infected with SARS-CoV-2 (COVID-19) experience mild, non-specific symptoms, but many develop severe symptoms associated with an excessive inflammatory response. Elevated plasma concentrations of soluble urokinase plasminogen activator receptor (suPAR) provide early warning of progression to severe respiratory failure (SRF) or death, but access to suPAR testing may be limited. The Severe COvid Prediction Estimate (SCOPE) score, derived from circulating concentrations of C-reactive protein, D- dimers, interleukin-6, and ferritin among patients not receiving non-invasive or invasive mechanical ventilation during the SAVE-MORE study, offers predictive accuracy for progression to SRF or death within 14 days comparable to that of a suPAR concentration of ≥6 ng/mL (area under receiver operator characteristic curve 0.81 for both). The SCOPE score is validated in two similar independent cohorts. A SCOPE score of 6 or more is an alternative to suPAR for predicting progression to SRF or death within 14 days of hospital admission for pneumonia, and it can be used to guide treatment decisions