Stress, vulnerability and resilience: a developmental approach

Our studies support the hypothesis that all experiences during life, including early experiences in-utero, will influence the expression of genes, and in the end the socio-emotional and cognitive development later in life. This model of ‘epigenetic programming’ suggests the predictive power of the environment in-utero and early childhood on mental health later in life. The stress diathesis model proposes that this association is probably determined by a neurodevelopmental pathway with individual differences in neural and endocrine responses to stress. However, genotypes influencing the neural and endocrine stress responses are ‘plastic’, which implies that they can be modulated by environmental influences during life

Recruiting psychiatrists - The Singapore experience

10.1192/pb.32.7.275bPsychiatric Bulletin32727

Determinants of successful aging using a multidimensional definition among chinese elderly in singapore

10.1097/JGP.0b013e31819a808eAmerican Journal of Geriatric Psychiatry175407-41

Network Analyses of Maternal Pre- and Post-Partum Symptoms of Depression and Anxiety

10.3389/fpsyt.2020.00785Frontiers in Psychiatry1178

The psychological impact of an adenoidectomy and adenotonsillectomy on young children

10.1016/j.ijporl.2009.10.005International Journal of Pediatric Otorhinolaryngology74137-4

The influence of perceived parenting styles on socio-emotional development from pre-puberty into puberty

10.1007/s00787-017-1016-9European Child and Adolescent Psychiatry27137-4

Sleep duration in infants was not associated with myopia at 3 years

10.22608/APO.2017390Asia-Pacific Journal of Ophthalmology72102-108GUSTO (Growing up towards Healthy Outcomes

Influence of birth weight on internalizing traits modulated by serotonergic genes

10.1542/peds.2010-3714Pediatrics1285e1250-e1258PEDI

General distress and symptoms of anxiety and depression: A factor analysis in two cohorts of dialysis patients

Objective: Depression and anxiety often coexist in patients with end -stage -kidney disease. Recently, studies showed that a composite ?general distress score ? which combines depression and anxiety symptoms provides a good fit in dialysis and oncology patients. We aim to investigate if the three most frequently used self -report questionnaires to measure depression and anxiety in dialysis patients are sufficiently unidimensional to warrant the use of such a general distress score in two cohorts of dialysis patients. Methods: This study includes two prospective observational cohorts of dialysis patients (total n = 749) which measured depression and anxiety using Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Hospital Anxiety and Depression Scale (HADS). Confirmatory factor analyses was used to investigate both a strictly unidimensional model and a multidimensional bifactor model that includes a general distress, depression and anxiety factor. The comparative fit index (CFI) and The Root Mean Square Error of Approximation (RMSEA) were used as model fit indices. Results: Factor analysis did not show a good fit for a strictly unidimensional general distress factor for both the BDI/BAI and HADS (CFI 0.690 and 0.699, RMSEA 0.079 and 0.125 respectively). The multidimensional model performed better with a moderate fit for the BDI/BAI and HADS (CFI 0.873 and 0.839, RMSEA 0.052 and 0.102). Conclusions: This data shows that the BDI/BAI and HADS are insufficiently unidimensional to warrant the use of a general distress score in dialysis patients without also investigating anxiety and depression separately. Future research is needed whether the use of a general distress score might be beneficial to identify patients in need of additional (psychological) support.Clinical epidemiolog

Maternal Parenting Stress, Child Exuberance, and Preschoolers’ Behavior Problems

10.1111/cdev.13180Child Development901136-146CHDEAGUSTO (Growing up towards Healthy Outcomes