Uncertain Flow Visualization using LIC

In this paper we look at the Line Integral Convolution method for flow visualization and ways in which this can be applied to the visualization of two dimensional, steady flow fields in the presence of uncertainty. To achieve this, we start by studying the method and reviewing the history of modifications other authors have made to it in order to improve its efficiency or capabilities, and using these as a base for the visualization of uncertain flow fields. Finally, we apply our methodology to a case study from the field of oceanography

Contouring with uncertainty

As stated by Johnson [Joh04], the visualization of uncertainty remains one of the major challenges for the visualization community. To achieve this, we need to understand and develop methods that allow us not only to consider uncertainty as an extra variable within the visualization process, but to treat it as an integral part. In this paper, we take contouring, one of the most widely used visualization techniques for two dimensional data, and focus on extending the concept of contouring to uncertainty. We develop special techniques for the visualization of uncertain contours. We illustrate the work through application to a case study in oceanography

Liver segmentation using automatically defined patient specific B-Spline surface models

This paper presents a novel liver segmentation algorithm. This is a model-driven approach; however, unlike previous techniques which use a statistical model obtained from a training set, we initialize patient-specific models directly from their own pre-segmentation. As a result, the non-trivial problems such as landmark correspondences, model registration etc. can be avoided. Moreover, by dividing the liver region into three sub-regions, we convert the problem of building one complex shape model into constructing three much simpler models, which can be fitted independently, greatly improving the computation efficiency. A robust graph-based narrow band optimal surface fitting scheme is also presented. The proposed approach is evaluated on 35 CT images. Compared to contemporary approaches, our approach has no training requirement and requires significantly less processing time, with an RMS error of 2.440.53mm against manual segmentation

The volume in focus: hardwareassisted focus and context effects for volume visualization

In many volume visualization applications there is some region of specific interest where we wish to see fine detail - yet we do not want to lose an impression of the overall picture. In this research we apply the notion of focus and context to texture-based volume rendering. A framework has been developed that enables users to achieve fast volumetric distortion and other effects of practical use. The framework has been implemented through direct programming of the graphics processor and integrated into a volume rendering system. Our driving application is the effective visualization of aneurysms, an important issue in neurosurgery. We have developed and evaluated an easy-to-use system that allows a neurosurgicalteam to explore the nature of cerebral aneurysms, visualizing the aneurysm itself in fine detail while still retaining a view of the surrounding vasculature

Do you see what I mean?

Visualizers, like logicians, have long been concerned with meaning. Generalizing from MacEachren's overview of cartography, visualizers have to think about how people extract meaning from pictures (psychophysics), what people understand from a picture (cognition), how pictures are imbued with meaning (semiotics), and how in some cases that meaning arises within a social and/or cultural context. If we think of the communication acts carried out in the visualization process further levels of meaning are suggested. Visualization begins when someone has data that they wish to explore and interpret; the data are encoded as input to a visualization system, which may in its turn interact with other systems to produce a representation. This is communicated back to the user(s), who have to assess this against their goals and knowledge, possibly leading to further cycles of activity. Each phase of this process involves communication between two parties. For this to succeed, those parties must share a common language with an agreed meaning. We offer the following three steps, in increasing order of formality: terminology (jargon), taxonomy (vocabulary), and ontology. Our argument in this article is that it's time to begin synthesizing the fragments and views into a level 3 model, an ontology of visualization. We also address why this should happen, what is already in place, how such an ontology might be constructed, and why now

Targeted therapies to improve CFTR function in cystic fibrosis

Cystic fibrosis is the most common genetically determined, life-limiting disorder in populations of European ancestry. The genetic basis of cystic fibrosis is well established to be mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that codes for an apical membrane chloride channel principally expressed by epithelial cells. Conventional approaches to cystic fibrosis care involve a heavy daily burden of supportive treatments to combat lung infection, help clear airway secretions and maintain nutritional status. In 2012, a new era of precision medicine in cystic fibrosis therapeutics began with the licensing of a small molecule, ivacaftor, which successfully targets the underlying defect and improves CFTR function in a subgroup of patients in a genotype-specific manner. Here, we review the three main targeted approaches that have been adopted to improve CFTR function: potentiators, which recover the function of CFTR at the apical surface of epithelial cells that is disrupted in class III and IV genetic mutations; correctors, which improve intracellular processing of CFTR, increasing surface expression, in class II mutations; and production correctors or read-through agents, which promote transcription of CFTR in class I mutations. The further development of such approaches offers great promise for future therapeutic strategies in cystic fibrosis

Relationships Between Quantum and Classical Mechanics using the Representation Theory of the Heisenberg Group

This thesis is concerned with the representation theory of the Heisenberg group and its applications to both classical and quantum mechanics. We continue the development of $p$-mechanics which is a consistent physical theory capable of describing both classical and quantum mechanics simultaneously. $p$-Mechanics starts from the observation that the one dimensional representations of the Heisenberg group play the same role in classical mechanics which the infinite dimensional representations play in quantum mechanics. In this thesis we introduce the idea of states to $p$-mechanics. $p$-Mechanical states come in two forms: elements of a Hilbert space and integration kernels. In developing $p$-mechanical states we show that quantum probability amplitudes can be obtained using solely functions/distributions on the Heisenberg group. This theory is applied to the examples of the forced, harmonic and coupled oscillators. In doing so we show that both the quantum and classical dynamics of these systems can be derived from the same source. Also using $p$-mechanics we simplify some of the current quantum mechanical calculations. We also analyse the role of both linear and non-linear canonical transformations in $p$-mechanics. We enhance a method derived by Moshinsky for studying the passage of canonical transformations from classical to quantum mechanics. The Kepler/Coulomb problem is also examined in the $p$-mechanical context. In analysing this problem we show some limitations of the current $p$-mechanical approach. We then use Klauder's coherent states to generate a Hilbert space which is particularly useful for the Kepler/Coulomb problem.Comment: PhD Thesis from 2004, 140 page

Using high resolution displays for high resolution cardiac data

The ability to perform fast, accurate, high resolution visualization is fundamental to improving our understanding of anatomical data. As the volumes of data increase from improvements in scanning technology, the methods applied to rendering and visualization must evolve. In this paper we address the interactive display of data from high resolution MRI scanning of a rabbit heart and subsequent histological imaging. We describe a visualization environment involving a tiled LCD panel display wall and associated software which provide an interactive and intuitive user interface. The oView software is an OpenGL application which is written for the VRJuggler environment. This environment abstracts displays and devices away from the application itself, aiding portability between different systems, from desktop PCs to multi-tiled display walls. Portability between display walls has been demonstrated through its use on walls at both Leeds and Oxford Universities. We discuss important factors to be considered for interactive 2D display of large 3D datasets, including the use of intuitive input devices and level of detail aspects