A study of anti-fat bias among Danish general practitioners and whether this bias and general practitioners' lifestyle can affect treatment of tension headache in patients with obesity

Objectives: The study investigated whether treatment options for episodic tension-type headache vary among general practitioners (GPs) in Denmark depending on the patients’ weight status and gender, and whether these decisions can be explained by the GPs’ own anti-fat bias and lifestyle. Methods: A cross-sectional questionnaire study with responses from 240 GPs on measures of anti-fat bias, healthiness of GPs’ lifestyles, and reported patient treatment decisions. Results: GPs tended to exhibit negative explicit and implicit anti-fat bias. There were no differences in choice of medical treatment for patients with obesity and those of a normal weight. GPs were more likely to advise a general health check to a patient with obesity (p < 0.001). GPs treating a male patient with obesity were less likely to believe that their patient would comply with the advised treatment compared to those with a male patient of normal weight. Compared with other patient types (4.4–7.7%), GPs who treated a male patient with obesity (27.9%) were more likely to advise a general health check only and no diary-keeping or follow-up consultation (p < 0.001). This was explained by the healthiness of the GPs’ lifestyles (Spearman’s ρ = 0.367; p < 0.01). Conclusion: Despite the presence of clear anti-fat bias, there were no differences in medical treatment, and GPs managed the general health of patients with obesity proactively. The fact that the GPs’ own lifestyle influenced the likelihood that they would recommend diary-keeping and follow-up consultations for male patients with obesity is remarkable and requires further investigation

The productive role of material design artefacts in participatory design events

ABSTRACT Physical design artefacts are employed in a wide range of participatory design events, yet there are few comprehensive discussions of the properties and qualities of them in the literature of the field. In this paper, we examine the productive role of material design artefacts in participatory design events. First, we offer a theoretical foundation for understanding material artefacts in design, based on pragmatist philosophy. Then, we employ this theoretical perspective to analyse a case in which a range of physical design materials was employed to envision and explore a projected building, the "Urban Media Space" a new library in Aarhus, Denmark. Drawing on examples from this case, we define a series of design considerations for employing material design artefacts in collaborative design events. Our contribution is valuable both in advancing the theoretical standpoint of interaction design in general, and in allowing participatory design practitioners to reflect on their use of material design artefacts when involving users

Deadheads at high altitude: Summary from the 10th Workshop on Subfossil Chironomidae, Finse, Norway, 2011.

Summary from the 10th Workshop on Subfossil Chironomidae, Finse, Norway, 2011

Scenarieorienteret planlægning i matematik Matematiklæreres opmærksomhed på sikre og usikre elevers motivation

Artiklen diskuterer, hvordan man kan undersøge læreres forståelse af og forestillinger om usikre og sikre elevers motivation i faget matematik. Afsættet tages i en sammenlignende undersøgelse i interventionsprojektet Tegn på Læring. Projektets hypotese var, at et praksisnært kompetenceudvik-lingsforløb med scenarieorienteret forberedelse som centralt omdrejningspunkt kan skærpe interventi-onslærernes forståelse af og forestillinger om sikre og usikre elevers motivation. Hypotesen er undersøgt ved at sammenligne lærere fra interventionsgruppen og lærere fra en kontrolgruppe. Forskellen mellem interventionslærerne og kontrolgruppelærerne er signifikante hvad angår de usikre elever. Dermed indikerer resultaterne, at lærerens scenarieorienterede forberedelse kan skærpe opmærksomheden på usikre elevers motivation i faget matematik

Anvendelse af læremidler i professionsuddannelserne

Casen er udbredt i professions-uddannelserne, og rigtigt anvendt kan casen bygge bro mellem teori og praksis og styrke de studerendes professionsfaglige dømmekraft

Mål, midler og scenarier

Resultater fra interventionsprojektet Tegn på Læring med øget adgang til læremidler og fokus på differentiering, faglig mestring og motivation

Tegn på Læring. Teoribaseret evaluering som metode til forskning i læremidler og undervisning

Blikket på en synlig/usynlig-akse i undervisning har været et retningsgivende perspektiv i projektet Tegn på læring, hvor vi har undersøgt sammenhænge mellem brug af læremidler og læring. Særligt fokus er der på motivation og undervisningsdifferentiering

Farnesylated heat shock protein 40 is a component of membrane-bound RISC in <i>Arabidopsis</i>

ARGONAUTE1 (AGO1) binds directly to small regulatory RNA and is a key effector protein of post-transcriptional gene silencing mediated by microRNA (miRNA) and small interfering RNA (siRNA) in Arabidopsis. The formation of an RNA-induced silencing complex (RISC) of AGO1 and small RNA requires the function of the heat shock protein 70/90 chaperone system. Some functions of AGO1 occur in association with endomembranes, in particular the rough endoplasmic reticulum (RER), but proteins interacting with AGO1 in membrane fractions remain unidentified. In this study, we show that the farnesylated heat shock protein 40 homologs, J2 and J3, associate with AGO1 in membrane fractions in a manner that involves protein farnesylation. We also show that three changes in AGO1 function are detectable in mutants in protein farnesylation and J2/J3. First, perturbations of the HSP40/70/90 pathway by mutation of J3, HSP90, and farnesyl transferase affect the amounts of AGO1 associated with membranes. Second, miRNA association with membrane-bound polysomes is increased in farnesyl transferase and farnesylation-deficient J2/J3 mutants. Third, silencing by noncell autonomously acting short interfering RNAs is impaired. These observations highlight the involvement of farnesylated J2/J3 in small RNA-mediated gene regulation, and suggest that the importance of chaperone-AGO1 interaction is not limited to the RISC assembly process

Organismal benefits of transcription speed control at gene boundaries

RNA polymerase II (RNAPII) transcription is crucial for gene expression. RNAPII density peaks at gene boundaries, associating these key regions for gene expression control with limited RNAPII movement. The connections between RNAPII transcription speed and gene regulation in multicellular organisms are poorly understood. Here, we directly modulate RNAPII transcription speed by point mutations in the second largest subunit of RNAPII in Arabidopsis thaliana. A RNAPII mutation predicted to decelerate transcription is inviable, while accelerating RNAPII transcription confers phenotypes resembling auto‐immunity. Nascent transcription profiling revealed that RNAPII complexes with accelerated transcription clear stalling sites at both gene ends, resulting in read‐through transcription. The accelerated transcription mutant NRPB2‐Y732F exhibits increased association with 5′ splice site (5′SS) intermediates and enhanced splicing efficiency. Our findings highlight potential advantages of RNAPII stalling through local reduction in transcription speed to optimize gene expression for the development of multicellular organisms.SynopsisRNAPII mutations that accelerate transcription cause auto‐immunity‐like phenotypes, read‐through transcription at RNAPII stalling sites and enhanced splicing in Arabidopsis, indicating that controlled transcription speed is required for optimal gene expression and plant development.A point mutation in RNAPII that increases the speed of RNAPII transcription triggers auto‐immunity‐like phenotypes.plaNET‐seq reveals reduced RNAPII stalling at gene boundaries in fast transcription mutants.Increasing the speed of transcription reduces the efficiency of transcriptional termination, resulting in read‐through transcription that blurs the spatial separation of genes.Accelerating RNAPII transcription enhances splicing efficiency in the multi‐cellular context.RNAPII mutations that accelerate transcription cause auto‐immunity‐like phenotypes, read‐through transcription at RNAPII stalling sites and enhanced splicing in Arabidopsis, indicating that controlled transcription speed is required for optimal gene expression and plant development.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154978/1/embr201949315-sup-0001-EVFigs.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154978/2/embr201949315.reviewer_comments.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154978/3/embr201949315.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154978/4/embr201949315_am.pd