Significant results for post-hoc comparisons of the significant word-category x group interaction effect in the amygdala, conducted at p = 0.005 uncorrected, representing a Bonferroni-corrected 0.05 probability.

<p>Coordinates are given in MNI space.</p><p>SP, Social Phobia patients; HC, healthy controls.</p><p>Significant results for post-hoc comparisons of the significant word-category x group interaction effect in the amygdala, conducted at p = 0.005 uncorrected, representing a Bonferroni-corrected 0.05 probability.</p

Correlations between the clinical measures and the behavioral rating data for negative, SP-related, positive, and neutral words within the group of social phobia patients (Pearson's correlation/p-value (2-tailed)).

<p>SPS, Social Phobia Scale; SIAS, Social Interaction Anxiety Scale; BDI, Beck Depression Inventory; STAI-T, State-Trait Anxiety Inventory, Trait version; STAI-S, State-Trait Anxiety Inventory, State version. Significant correlations are displayed in bold letters.</p><p>Correlations between the clinical measures and the behavioral rating data for negative, SP-related, positive, and neutral words within the group of social phobia patients (Pearson's correlation/p-value (2-tailed)).</p

Correlations with disorder severity.

<p><b>a</b>) Left: Association of the patients' SPS-scores with right amygdala responsiveness to SP-related versus negative words, rendered on an anatomical template in MNI-space. Color bar, correlation coefficient <i>r</i>. Right: Scatter plot depicting the positive correlation of the mean cluster activation values (left panel) and the SPS-scores. <b>b</b>) Left: Association of the patients' SPS-scores and the functional connectivity between the left amygdala and the right BA 10 and 11, rendered on an anatomical template in MNI-space. Color bar, correlation coefficient −<i>r</i>. Right: Scatter plot depicting the negative correlation of the mean cluster activation values (left panel) and the SPS-scores.</p

Region of interest analysis of the amygdala.

<p>Left: bar graphs depicting the mean contrast value for negative, SP-related, and positive versus neutral words extracted from x = −18, y = 0, z = −24. Error bars, SEM. Right: coronal view (y = 0), depicting the significant group x word category interaction in the bilateral amygdala.</p

Mean differences for patients with social phobia (SP) and healthy controls (HC) concerning age, verbal intelligence, depression (BDI), Trait- and State anxiety (STAI-T and STAI-S) and social phobia symptoms (SPS/SIAS).

<p><i>M</i> =  Mean; SD  =  standard deviation. BDI, Beck Depression Inventory; STAI-T, State-Trait Anxiety Inventory, Trait version; STAI-S, State-Trait Anxiety Inventory, State version; SPS, Social Phobia Scale; SIAS, Social Interaction Anxiety Scale.</p>a<p>Assessed with the Mehrfachwahl-Wortschatz-Intelligenztest <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0109949#pone.0109949-Lehrl1" target="_blank">[47]</a>.</p><p>Mean differences for patients with social phobia (SP) and healthy controls (HC) concerning age, verbal intelligence, depression (BDI), Trait- and State anxiety (STAI-T and STAI-S) and social phobia symptoms (SPS/SIAS).</p