Self-Reporting, Recognition of Symptoms and Characteristics of Anxiety and Depression and Seeking Professional Help

This study examined whether adults (age 25 to 50) self-report symptoms of anxiety and/or depression and whether these individuals accurately identify the symptoms that are associated with Generalized Anxiety Disorder and Major Depressive Disorder. Do these individuals believe the symptoms associated with Generalized Anxiety Disorder and Major Depressive Disorder are severe enough to seek professional help? The participants included 30 females and 20 males. Zung’s Self-Rating Depression (SDS; 1971) and Self-Rating Anxiety Scale (SAS; 1965) were administered. A third questionnaire was also developed to help identify if individuals are able to accurately identify symptoms, distinguish between the two disorders, and rate if the symptoms are considered severe enough to seek professional help. The results of a Pearson correlation indicated that there was a negative correlation between assessed anxiety or depression and one’s ability to accurately identify the symptoms. Anxiety and depression were found to be highly correlated and a /-test showed significant differences between those who knew someone who sought professional help for anxiety and/or depression and those who reported they would seek help themselves if diagnosed with a mental health disorder

Programas de controle das mastites causadas por microrganismos contagiosos e do ambiente

Este trabalho foi elaborado com o objetivo de apresentar os conceitos em que se baseiam os programas de controle da mastite, em uso na maioria das indústrias leiteiras desenvolvidas. Foram abordados os fundamentos dos programas de controle, as características dos patógenos mais comuns, os fatores relacionados à ocorrência da doença e a síntese do programa de controle. Destina-se prioritariamente a médicos veterinários e estudantes, embora outros profissionais e produtores interessados no tema possam também usá-lo.bitstream/item/81916/1/Programas-de-controle-das-mastites.pd

Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: Implication for neuroprotective therapies

Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been proposed for Huntington's disease (HD) treatment. However, our group has recently reported reduced levels of TrkB in HD mouse models and HD human brain suggesting that besides a decrease on BDNF levels a reduction of TrkB expression could also contribute to diminished neurotrophic support in HD. BDNF can also bind to p75 neurotrophin receptor (p75(NTR)) modulating TrkB signaling. Therefore, in this study we have analyzed the levels of p75(NTR) in several HD models, as well as in HD human brain. Our data demonstrates a p75(NTR)/TrkB imbalance in the striatum of two different HD mouse models, Hdh(Q111/111) homozygous knockin mice and R6/1 mice that was also manifested in the putamen of HD patients. The imbalance between TrkB and p75(NTR) levels in a HD cellular model did not affect BDNF-mediated TrkB activation of prosurvival pathways but induced activation of apoptotic cascades as demonstrated by increased JNK phosphorylation. Moreover, BDNF failed to protect mutant huntingtin striatal cells transfected with p75(NTR) against NMDA-mediated excitotoxicity, which was associated with decreased Akt phosphorylation. Interestingly, lack of Akt activation following BDNF and NMDA treatment correlated with increased PP1 levels. Accordingly, pharmacological inhibition of PP1 by okadaic acid (OA) prevented mutant huntingtin striatal cell death induced by NMDA and BDNF. Altogether, our findings demonstrate that the p75(NTR)/TrkB imbalance induced by mutant huntingtin in striatal cells associated with the aberrant activity of PP1 disturbs BDNF neuroprotection likely contributing to increasing striatal vulnerability in HD. On the basis of this data we hypothesize that normalization of p75(NTR) and/or TrkB expression or their signaling will improve BDNF neuroprotective therapies in HD. Cell Death and Disease (2013) 4, e595; doi:10.1038/cddis.2013.116; published online 18 April 201

Rinite atrófica dos suínos: alternativas de controle.

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