3 research outputs found
gcodeml: A Grid-enabled Tool for Detecting Positive Selection in Biological Evolution
One of the important questions in biological evolution is to know if certain
changes along protein coding genes have contributed to the adaptation of
species. This problem is known to be biologically complex and computationally
very expensive. It, therefore, requires efficient Grid or cluster solutions to
overcome the computational challenge. We have developed a Grid-enabled tool
(gcodeml) that relies on the PAML (codeml) package to help analyse large
phylogenetic datasets on both Grids and computational clusters. Although we
report on results for gcodeml, our approach is applicable and customisable to
related problems in biology or other scientific domains.Comment: 10 pages, 4 figures. To appear in the HealthGrid 2012 con
Selectome update: quality control and computational improvements to a database of positive selection
Selectome (http://selectome.unil.ch/) is a database of positive selection, based on a branch-site likelihood test. This model estimates the number of nonsynonymous substitutions (dN) and synonymous substitutions (dS) to evaluate the variation in selective pressure (dN/dS ratio) over branches and over sites. Since the original release of Selectome, we have benchmarked and implemented a thorough quality control procedure on multiple sequence alignments, aiming to provide minimum false-positive results. We have also improved the computational efficiency of the branch-site test implementation, allowing larger data sets and more frequent updates. Release 6 of Selectome includes all gene trees from Ensembl for Primates and Glires, as well as a large set of vertebrate gene trees. A total of 6810 gene trees have some evidence of positive selection. Finally, the web interface has been improved to be more responsive and to facilitate searches and browsin
Selectome update: quality control and computational improvements to a database of positive selection.
Selectome (http://selectome.unil.ch/) is a database of positive selection, based on a branch-site likelihood test. This model estimates the number of nonsynonymous substitutions (dN) and synonymous substitutions (dS) to evaluate the variation in selective pressure (dN/dS ratio) over branches and over sites. Since the original release of Selectome, we have benchmarked and implemented a thorough quality control procedure on multiple sequence alignments, aiming to provide minimum false-positive results. We have also improved the computational efficiency of the branch-site test implementation, allowing larger data sets and more frequent updates. Release 6 of Selectome includes all gene trees from Ensembl for Primates and Glires, as well as a large set of vertebrate gene trees. A total of 6810 gene trees have some evidence of positive selection. Finally, the web interface has been improved to be more responsive and to facilitate searches and browsing