Dynamic Resectorization and Coordination Technology: An Evaluation of Air Traffic Control Complexity

The work described in this report is done under contract with the National Aeronautics and Space Administration (NASA) to support the Advanced Air Transportation Technology (AATR) program. The goal of this program is to contribute to and accelerate progress in Advanced Air Transportation Technologies. Wyndemere Incorporated is supporting this goal by studying the complexity of the Air Traffic Specialist's role in maintaining the safety of the Air Transportation system. It is envisioned that the implementation of Free Flight may significantly increase the complexity and difficulty of maintaining this safety. Wyndemere Incorporated is researching potential methods to reduce this complexity. This is the final report for the contract

Direct measurements of helium and hydrogen ion concentration and total ion density to an altitude of 940 kilometers

Measurement of ion concentration and total ion density in exosphere using mass spectrometer and electrostatic prob

Tubal ligation and risk of breast cancer

Although it has been demonstrated in previous studies that tubal ligation can have widespread effects on ovarian function, including a decrease in the risk of subsequent ovarian cancer, few studies have evaluated effects on breast cancer risk. In a population-based case–control study of breast cancer among women 20–54 years of age conducted in three geographic areas, previous tubal ligations were reported by 25.3% of the 2173 cases and 25.8% of the 1990 controls. Initially it appeared that tubal ligations might impart a slight reduction in risk, particularly among women undergoing the procedure at young ages (< 25 years). However, women were more likely to have had the procedure if they were black, less educated, young when they bore their first child, or multiparous. After accounting for these factors, tubal ligations were unrelated to breast cancer risk (relative risk (RR) = 1.09, 95% confidence interval (CI) 0.9–1.3), with no variation in risk by age at, interval since, or calendar year of the procedure. The relationship of tubal ligations to risk did not vary according to the presence of a number of other risk factors, including menopausal status or screening history. Furthermore, effects of tubal ligation were similar for all stages at breast cancer diagnosis. Further studies would be worthwhile given the biologic plausibility of an association. However, future investigations should include information on type of procedure performed (since this may relate to biologic effects) as well as other breast cancer risk factors. © 2000 Cancer Research Campaig

Estrogen and Hippocampal Plasticity in Rodent Models

Accumulating evidence indicates that ovarian hormones regulate a wide variety of non-reproductive functions in the central nervous system by interacting with several molecular and cellular processes. A growing animal literature using both adult and aged rodent models indicates that 17β-estradiol, the most potent of the biologically relevant estrogens, facilitates some forms of learning and memory, in particular those that involve hippocampal-dependent tasks. A recently developed triple-transgenic mouse (3xTg-AD) has been widely used as an animal model of Alzheimer\u27s disease, as this mouse exhibits an age-related and progressive neuropathological phenotype that includes both plaque and tangle pathology mainly restricted to hippocampus, amygdala and cerebral cortex. In this report, we examine recent studies that compare the effects of ovarian hormones on synaptic transmission and synaptic plasticity in adult and aged rodents. A better understanding of the non-reproductive functions of ovarian hormones has far-reaching implications for hormone therapy to maintain health and function within the nervous system throughout aging

Inexpensive and Portable System for Dexterous High-Density Myoelectric Control of Multiarticulate Prostheses

Multiarticulate bionic arms are now capable of mimicking the endogenous movements of the human hand. 3D-printing has reduced the cost of prosthetic hands themselves, but there is currently no low-cost alternative to dexterous electromyographic (EMG) control systems. To address this need, we developed an inexpensive (~$675) and portable EMG control system by integrating low-cost microcontrollers with an EMG acquisition device. We validated signal acquisition by comparing the signal-to-noise ratio (SNR) of our system with that of a high-end research-grade system. We also demonstrate the ability to use the low-cost control system for proportional and independent control of various prosthetic hands in real-time. We found that the SNR of the low-cost control system was statistically no worse than 44% of the SNR of a research-grade control system. The RMSEs of predicted hand movements (from a modified Kalman filter) were typically a few percent better than, and not more than 6% worse than, RMSEs of a research-grade system for up to six degrees of freedom when only relatively few (six) EMG electrodes were used. However, RMSEs were generally higher than RMSEs of research-grade systems that utilize considerably more (32) EMG electrodes, guiding future work towards increasing electrode count. Successful instantiation of this low-cost control system constitutes an important step towards the commercialization and wide-spread availability of dexterous bionic hands.Comment: IEEE EMBC 202