Minimal underlying data.

(XLSX)</p

Change of daily process measures over the study period among the whole cohort and in subgroups of ICUs with baseline spontaneous trial (SAT) compliance of >50% and ≤50.

(PDF)</p

List of participating sites and ethics committee approvals.

(PDF)</p

Data measures definitions.

(PDF)</p

Characteristics of participating sites.

IQR: interquartile range. (PDF)</p

Outcomes.

Outcomes.</p

Study flow diagram.

Study flow diagram.</p

CONSORT 2010 checklist of information to include when reporting a randomised trial*.

(DOC)</p

List of interventions.

(PDF)</p

Change of ICU mortality and ventilator-associated events (VAE) over the study period among the whole cohort and in subgroups of ICUs with baseline spontaneous trial (SAT) compliance of >50% and ≤50%.

(PDF)</p