Replication factor-A from Saccharomyces cerevisiae is encoded by three essential genes coordinately expressed at S phase

Replication factor-A (RF-A) is a three-subunit protein complex originally purified from human cells as an essential component for SV40 DNA replication in vitro. We have previously identified a functionally homologous three-subunit protein complex from the yeast Saccharomyces cerevisiae. Here we report the cloning and characterization of the genes encoding RF-A from S. cerevisiae. Each of the three subunits is encoded by a single essential gene. Cells carrying null mutations in any of the three genes arrest as budded and multiply budded cells. All three genes are expressed in a cell-cycle-dependent manner; the mRNA for each subunit peaks at the G1/S-phase boundary. A comparison of protein sequences indicates that the human p34 subunit is 29% identical to the corresponding RFA2 gene product. However, expression of the human protein fails to rescue the rfa2::TRP1 disruption

The isolation of gravitational instantons: Flat tori V flat R^4

The role of topology in the perturbative solution of the Euclidean Einstein equations about flat instantons is examined.Comment: 15 pages, ICN-UNAM 94-1

Tuning electronic structures via epitaxial strain in Sr2IrO4 thin films

We have synthesized epitaxial Sr2IrO4 thin-films on various substrates and studied their electronic structures as a function of lattice-strains. Under tensile (compressive) strains, increased (decreased) Ir-O-Ir bond-angles are expected to result in increased (decreased) electronic bandwidths. However, we have observed that the two optical absorption peaks near 0.5 eV and 1.0 eV are shifted to higher (lower) energies under tensile (compressive) strains, indicating that the electronic-correlation energy is also affected by in-plane lattice-strains. The effective tuning of electronic structures under lattice-modification provides an important insight into the physics driven by the coexisting strong spin-orbit coupling and electronic correlation.Comment: 9 pages, 5 figures, 1 tabl

Entropy-Based Strategies for Multi-Bracket Pools

Much work in the March Madness literature has discussed how to estimate the probability that any one team beats any other team. There has been strikingly little work, however, on what to do with these win probabilities. Hence we pose the multi-brackets problem: given these probabilities, what is the best way to submit a set of $n$ brackets to a March Madness bracket challenge? This is an extremely difficult question, so we begin with a simpler situation. In particular, we compare various sets of $n$ randomly sampled brackets, subject to different entropy ranges or levels of chalkiness (rougly, chalkier brackets feature fewer upsets). We learn three lessons. First, the observed NCAA tournament is a "typical" bracket with a certain "right" amount of entropy (roughly, a "right" amount of upsets), not a chalky bracket. Second, to maximize the expected score of a set of $n$ randomly sampled brackets, we should be successively less chalky as the number of submitted brackets increases. Third, to maximize the probability of winning a bracket challenge against a field of opposing brackets, we should tailor the chalkiness of our brackets to the chalkiness of our opponents' brackets

Coupling of the lattice and superlattice deformations and hysteresis in thermal expansion for the quasi one-dimensional conductor TaS3_3

An original interferometer-based setup for measurements of length of needle-like samples is developed, and thermal expansion of o-TaS$_3$ crystals is studied. Below the Peierls transition the temperature hysteresis of length $L$ is observed, the width of the hysteresis loop $\delta L/L$ being up to $5 \cdot 10^{-5}$. The behavior of the loop is anomalous: the length changes so that it is in front of its equilibrium value. The hysteresis loop couples with that of conductivity. The sign and the value of the length hysteresis are consistent with the strain dependence of the charge-density waves (CDW) wave vector. With lowering temperature down to 100 K the CDW elastic modulus grows achieving a value comparable with the lattice Young modulus. Our results could be helpful in consideration of different systems with intrinsic superstructures.Comment: 4 pages, 3 figures. Phys. Rev. Lett., accepted for publicatio

Initial Data for General Relativity with Toroidal Conformal Symmetry

A new class of time-symmetric solutions to the initial value constraints of vacuum General Relativity is introduced. These data are globally regular, asymptotically flat (with possibly several asymptotic ends) and in general have no isometries, but a $U(1)\times U(1)$ group of conformal isometries. After decomposing the Lichnerowicz conformal factor in a double Fourier series on the group orbits, the solutions are given in terms of a countable family of uncoupled ODEs on the orbit space.Comment: REVTEX, 9 pages, ESI Preprint 12

Collision of spinning black holes in the close limit

In this paper we consider the collision of spinning holes using first order perturbation theory of black holes (Teukolsky formalism). With these results (along with ones, we published in the past) one can predict the properties of the gravitational waves radiated from the late stage inspiral of two spinning, equal mass black holes. Also we note that the energy radiated by the head-on collision of two spinning holes with spins (that are equal and opposite) aligned along the common axis is more than the case in which the spins are perpendicular to the axis of the collision.Comment: 6 pages, 3 figures, submitted to PR

A Bayesian analysis of the time through the order penalty in baseball

As a baseball game progresses, batters appear to perform better the more times they face a particular pitcher. The apparent drop-off in pitcher performance from one time through the order to the next, known as the Time Through the Order Penalty (TTOP), is often attributed to within-game batter learning. Although the TTOP has largely been accepted within baseball and influences many managers' in-game decision making, we argue that existing approaches of estimating the size of the TTOP cannot disentangle continuous evolution in pitcher performance over the course of the game from discontinuities between successive times through the order. Using a Bayesian multinomial regression model, we find that, after adjusting for confounders like batter and pitcher quality, handedness, and home field advantage, there is little evidence of strong discontinuity in pitcher performance between times through the order. Our analysis suggests that the start of the third time through the order should not be viewed as a special cutoff point in deciding whether to pull a starting pitcher.Comment: Accepted to JQA