276 research outputs found
Clinical Applications of Prostaglandins in Dogs and Cats
In the biological sciences today there are few substances that generate as much interest as prostaglandins. They have found widespread use in veterinary medicine, yet are only approved by the FDA for specific uses in cattle and horses. However, practical applications in the dog and cat have been reported by clinicians and have been evaluated in clinical research projects
Stably accessing octave-spanning microresonator frequency combs in the soliton regime
Microresonator frequency combs can be an enabling technology for optical
frequency synthesis and timekeeping in low size, weight, and power
architectures. Such systems require comb operation in low-noise, phase-coherent
states such as solitons, with broad spectral bandwidths (e.g., octave-spanning)
for self-referencing to detect the carrier-envelope offset frequency. However,
stably accessing such states is complicated by thermo-optic dispersion. For
example, in the Si3N4 platform, precisely dispersion-engineered structures can
support broadband operation, but microsecond thermal time constants have
necessitated fast pump power or frequency control to stabilize the solitons. In
contrast, here we consider how broadband soliton states can be accessed with
simple pump laser frequency tuning, at a rate much slower than the thermal
dynamics. We demonstrate octave-spanning soliton frequency combs in Si3N4
microresonators, including the generation of a multi-soliton state with a pump
power near 40 mW and a single-soliton state with a pump power near 120 mW. We
also develop a simplified two-step analysis to explain how these states are
accessed in a thermally stable way without fast control of the pump laser, and
outline the required thermal properties for such operation. Our model agrees
with experimental results as well as numerical simulations based on a
Lugiato-Lefever equation that incorporates thermo-optic dispersion. Moreover,
it also explains an experimental observation that a member of an adjacent mode
family on the red-detuned side of the pump mode can mitigate the thermal
requirements for accessing soliton states
Pneumococcal surface protein A of invasive Streptococcus pneumoniae isolates from Colombian children.
Pneumococcal surface protein A (PspA) elicits protection in mice against fatal bacteremia and sepsis caused by genetically diverse pneumococci and protects against carriage and lung infection. We determined the PspA families of invasive isolates of Streptococcus pneumoniae recovered from Colombian children <5 years of age. That 97.5% of Colombian isolates belong to PspA families 1 and 2 supports the hypothesis that a human PspA vaccine covering a few PspA families could be broadly effective
A Kerr-microresonator optical clockwork
Kerr microresonators generate interesting and useful fundamental states of
electromagnetic radiation through nonlinear interactions of continuous-wave
(CW) laser light. Using photonic-integration techniques, functional devices
with low noise, small size, low-power consumption, scalable fabrication, and
heterogeneous combinations of photonics and electronics can be realized. Kerr
solitons, which stably circulate in a Kerr microresonator, have emerged as a
source of coherent, ultrafast pulse trains and ultra-broadband
optical-frequency combs. Using the f-2f technique, Kerr combs support
carrier-envelope-offset phase stabilization for optical synthesis and
metrology. In this paper, we introduce a Kerr-microresonator optical clockwork
based on optical-frequency division (OFD), which is a powerful technique to
transfer the fractional-frequency stability of an optical clock to a lower
frequency electronic clock signal. The clockwork presented here is based on a
silicon-nitride (SiN) microresonator that supports an optical-frequency
comb composed of soliton pulses at 1 THz repetition rate. By electro-optic
phase modulation of the entire SiN comb, we arbitrarily generate
additional CW modes between the SiN comb modes; operationally, this
reduces the pulse train repetition frequency and can be used to implement OFD
to the microwave domain. Our experiments characterize the residual frequency
noise of this Kerr-microresonator clockwork to one part in , which
opens the possibility of using Kerr combs with high performance optical clocks.
In addition, the photonic integration and 1 THz resolution of the SiN
frequency comb makes it appealing for broadband, low-resolution liquid-phase
absorption spectroscopy, which we demonstrate with near infrared measurements
of water, lipids, and organic solvents
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Are great Cascadia earthquakes recorded in the sedimentary records from small forearc lakes?
Here we investigate sedimentary records from four small inland lakes located in the southern Cascadia forearc region for evidence of earthquakes. Three of these lakes are in the Klamath Mountains near the Oregon–California border, and one is in the central Oregon Coast range. The sedimentary sequences recovered from these lakes are composed of normal lake sediment interbedded with disturbance event layers. The thickest of these layers are graded, and appear to be turbidites or linked debrites (turbidites with a basal debris-flow deposit), suggesting rapid deposition. Variations in particle size and organic content of these layers are reflected in the density and magnetic susceptibility data. The frequency and timing of these events, based on radiocarbon ages from detrital organics, is similar to the offshore seismogenic turbidite record from trench and slope basin cores along the Cascadia margin. Stratigraphic correlation of these anomalous deposits based on radiocarbon ages, down-core density, and magnetic susceptibility data between lake and offshore records suggest synchronous triggering. The areal extent and multiple depositional environments over which these events appear to correlate suggest that these deposits were most likely caused by shaking during great Cascadia earthquakes.This is the publisher’s final pdf. The published article is copyrighted by the author(s) and published by Copernicus Publications on behalf of the European Geosciences Union. The published article can be found at: http://www.natural-hazards-and-earth-system-sciences.net/
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