Brain activation during Executive Control contrast for patients with bulimia nervosa relative to healthy controls.

<p>The image shows an axial slices. For complete results, please refer to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161329#pone.0161329.t002" target="_blank">Table 2</a>. Executive control contrast Incongruent Target–Congruent Target. The whole-brain analysis was corrected for multiple comparisons using cluster thresholding of 40 voxels. Right, the mean beta values extracted from the region that differed significantly between the groups. BN: Bulimia nervosa, HC: Healthy controls, ACC: Anterior Cingulate Cortex.</p

Brain activation during Alertingcontrast for patients with bulimia nervosa relative to healthy controls.

<p>The images show three axial slices positioned superiorly to inferiorly from top to bottom. For complete results, please refer to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161329#pone.0161329.t002" target="_blank">Table 2</a>. Alerting contrast Double Cue–No Cue. The whole-brain analysis was corrected for multiple comparisons using cluster thresholding of 40 voxels. Right, the mean beta values extracted from the regions that differed significantly between the groups. BN: Bulimia nervosa, HC: Healthy controls, ACC: Anterior Cingulate Cortex.</p

Brain activation during Reorienting contrasts for patient with bulimia nervosa relative to healthy controls.

<p>The images show three axial slices positioned superiorly to inferiorly from top to bottom. For complete results, please refer to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0161329#pone.0161329.t002" target="_blank">Table 2</a>. Reorienting contrast Spatially Invalid Cue–Spatially Valid cue. The whole-brain analysis was corrected for multiple comparisons using cluster thresholding of 40 voxels. Right, the mean beta values extracted from the regions that differed significantly between the groups. BN: Bulimia nervosa, HC: Healthy controls, ACC: Anterior Cingulate Cortex.</p

Analysis of correlation with clinical parameters.

<p>Brain activations extracted from areas significantly different between BN and HC for Alerting, Reorienting and Executive Control were correlated with clinical parameters. Correlations were corrected for age, BMI, depression and anxiety scores. A: Hyperactive during Alerting, bilateral posterior cingulate correlated with global eating-disorder symptoms (SIAB total score); B: Hypoactive during Reorienting, temporo Parietal Junction (TPJ) correlated inversely with ADHD scores (WRI-total); C: Hypoactive during Executive Control, parahippocampal gyrus correlated inversely with impulsivity scores (BIS-total).</p

Paradigm of the Attention Network Task.

<p>A timeline of the task with several examples is shown from the lower left to the upper right. The task combines 4 cue conditions with 2 target conditions, which enables all 3 contrasts to be tested within a single experiment, thus eliminating the potential variance introduced by combining different tasks.</p

Demographics and clinical characteristics of female adolescents with bulimia nervosa and healthy controls.

<p>Demographics and clinical characteristics of female adolescents with bulimia nervosa and healthy controls.</p

Significant activation differences between BN and HC.

<p>Significant activation differences between BN and HC.</p