Grassland Resources and Protections in the Yellow River Source Zone on the Qinghai-Tibet Plateau

This paper summarises resources and protections of the Yellow River Source Zone on the Qinghai-Tibet Plateau. A concerted effort has been made to address concerns for overgrazing on the alpine steppe and alpine meadow landscapes in the source zone of the Yellow River. An assessment of the impacts of overgrazing includes consideration of the role of small mammals (on the one hand they are considered as a critical ecosystem engineer, on the other they are perceived as a major threatening pest). Analyzed in this paper are management options in the restoration of degraded grasslands

Developing an equitable agenda for international capacity strengthening courses: environmental pedagogies and knowledge co-production in the Philippines

Capacity strengthening activities – be that in the form of courses, workshops, seminars – have become embedded in research projects as a requirement for funding and as a means for researchers to demonstrate positive societal impacts. We apply qualitative research techniques including interviews, questionnaires and observations to scrutinise and document an international capacity strengthening course aimed at informing and supporting environmental management practice and policy in the Philippines. We appraise power gradients and dynamics between course instructors and participants from different cultures and geographical locations in the design and delivery of this course. We identify five key factors that course instructors should consider as part of their pedagogy: (i) active learning, (ii) knowledge scaffolding and consolidation, and (iii) situated learning, as well as being attuned to (iv) the language dynamics and (v) expertise and networking within the room when teaching the course. Practical efforts to address these issues require that instructors work with participants to co-produce knowledge, rather than assuming epistemic authority and imposing knowledge. This entails reflexive and adaptable practices before, during and after the course. It is recommended that such practices should be central to projects that include capacity strengthening activities, whether delivered locally or internationally

Managing at source and at scale: The use of geomorphic river stories to support rehabilitation of Anthropocene riverscapes in the East Coast Region of Aotearoa New Zealand

Recently uplifted, highly erodible rocks, and recurrent high intensity storms, generate exceedingly high erosion and sedimentation rates in the East Coast Region (Tairāwhiti) of Aotearoa New Zealand. Despite the recent nature of the Anthropocene record in global terms (∼650 years since Māori arrival, 250 years of colonial impacts), human disturbance has profoundly altered evolutionary trajectories of river systems across the region. Here we document catchment-by-catchment variability in anthropogenic signature as geomorphic river stories for five catchments (Waiapu, Hikuwai, Waimatā, Waipaoa, Mōtū). We show how targeted, fit-for-purpose process-based rehabilitation programmes that manage at source and at scale are required to facilitate river recovery in each of these catchments. The largest rivers in the region, Waiapu and Waipaoa, comprise steep, highly dissected terrains that are subject to recurrent hillslope failures, including systemic shallow landslides, occasional deep-seated rotational slumps and earthflows. Localised sediment input from large (>10 ha) gully mass movement complexes overwhelms valley floors. Targeted revegetation programmes are required to reduce extreme sediment inputs from these sources. Although there are fewer gully complexes in the Hikuwai, multiple landslips supply vast volumes of fine-grained sediment that aggrade and are recurrently reworked along channel margins in lowland reaches. Waimatā has no gully complexes and a smaller number of landslips, but large areas are subject to sediment input from earthflows. The terrace-constrained flume-like nature of this system efficiently flushes materials ‘from the mountains to the sea’, recurrently reworking materials along channel banks in a similar manner to the lower Hikuwai. Systematic reforestation in the middle-upper catchment and revegetation of riparian corridors is required to reduce sedimentation rates in these catchments. In contrast, terraces buffer sediment delivery from hillslopes in the upper Mōtū catchment, where a bedrock gorge separates large sediment stores along upper reaches from the lower catchment. As reworking of valley floor sediments in response to bed incision and reworking (expansion) of channel margins is the primary contemporary sediment source in this system, bed control structures and revegetation of riparian corridors are required as part of targeted sediment management plans. We contend that geomorphic river stories provide a coherent platform for Anthropocene rehabilitation strategies that work with the character, behaviour and evolutionary trajectories of river systems. Although this generic lens can be applied anywhere in the world, we highlight particular meanings and implications in Aotearoa New Zealand where such thinking aligns directly with Māori values that respect the mana (authority), mauri (lifeforce) and ora (wellbeing) of each and every river

River Styles and stream power analysis reveal the diversity of fluvial morphology in a Philippine tropical catchment

Characterisation of hydromorphological attributes is crucial for effective river management. Such information is often overlooked in tropical regions such as the Philippines where river management strategies mainly focus on issues around water quality and quantity. We address this knowledge gap using the River Styles Framework as a template to identify the diversity of river morphodynamics. We identify eight distinct River Styles (river types) in the Bislak catchment (586 km2) in the Philippines, showing considerable geomorphic diversity within a relatively small catchment area. Three River Styles in a Confined valley setting occupy 57% of the catchment area, another three in a partly confined valley setting occupy 37%, and two in the remaining 6% are found in a laterally unconfined valley setting. Five characteristic downstream patterns of River Styles were identified across the catchment. We observe that variation in channel slope for a given catchment area (i.e., total stream power) is insufficient to differentiate between river types. Hence, topographic analyses should be complemented with broader framed, catchment-specific approaches to river characterisation. The outputs and understandings from the geomorphic analysis of rivers undertaken in this study can support river management applications by explicitly incorporating understandings of river diversity and dynamics. This has the potential to reshape how river management is undertaken, to shift from reactive, engineering-based approaches that dominate in the Philippines, to more sustainable, ecosystem-based approaches to management

Fundamentals of neurogastroenterology: Basic science

This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee of international experts and represents an abbreviated version of their consensus document that will be published in its entirety in the forthcoming book and online version entitled Rome IV. It emphasizes recent advances in our understanding of the enteric nervous system, sensory physiology underlying pain, and stress signaling pathways. There is also a focus on neuroimmmune signaling and intestinal barrier function, given the recent evidence implicating the microbiome, diet, and mucosal immune activation in FGIDs. Together, these advances provide a host of exciting new targets to identify and treat FGIDs, and new areas for future research into their pathophysiology

The Impact of Thyroid Cancer and Post-Surgical Radioactive Iodine Treatment on the Lives of Thyroid Cancer Survivors: A Qualitative Study

BACKGROUND: Adjuvant treatment with radioactive iodine (RAI) is often considered in the treatment of well-differentiated thyroid carcinoma (WDTC). We explored the recollections of thyroid cancer survivors on the diagnosis of WDTC, adjuvant radioactive iodine (RAI) treatment, and decision-making related to RAI treatment. Participants provided recommendations for healthcare providers on counseling future patients on adjuvant RAI treatment. METHODS: We conducted three focus group sessions, including WDTC survivors recruited from two Canadian academic hospitals. Participants had a prior history of WDTC that was completely resected at primary surgery and had been offered adjuvant RAI treatment. Open-ended questions were used to generate discussion in the groups. Saturation of major themes was achieved among the groups. FINDINGS: There were 16 participants in the study, twelve of whom were women (75%). All but one participant had received RAI treatment (94%). Participants reported that a thyroid cancer diagnosis was life-changing, resulting in feelings of fear and uncertainty. Some participants felt dismissed as not having a serious disease. Some participants reported receiving conflicting messages from healthcare providers on the appropriateness of adjuvant RAI treatment or insufficient information. If RAI-related side effects occurred, their presence was not legitimized by some healthcare providers. CONCLUSIONS: The diagnosis and treatment of thyroid cancer significantly impacts the lives of survivors. Fear and uncertainty related to a cancer diagnosis, feelings of the diagnosis being dismissed as not serious, conflicting messages about adjuvant RAI treatment, and treatment-related side effects, have been raised as important concerns by thyroid cancer survivors

Nociceptors: a phylogenetic view

The ability to react to environmental change is crucial for the survival of an organism and an essential prerequisite is the capacity to detect and respond to aversive stimuli. The importance of having an inbuilt “detect and protect” system is illustrated by the fact that most animals have dedicated sensory afferents which respond to noxious stimuli called nociceptors. Should injury occur there is often sensitization, whereby increased nociceptor sensitivity and/or plasticity of nociceptor-related neural circuits acts as a protection mechanism for the afflicted body part. Studying nociception and nociceptors in different model organisms has demonstrated that there are similarities from invertebrates right through to humans. The development of technology to genetically manipulate organisms, especially mice, has led to an understanding of some of the key molecular players in nociceptor function. This review will focus on what is known about nociceptors throughout the Animalia kingdom and what similarities exist across phyla; especially at the molecular level of ion channels

Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

AbstractUnderstanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics.</jats:p