Nonparametric Regression using the Concept of Minimum Energy

It has recently been shown that an unbinned distance-based statistic, the energy, can be used to construct an extremely powerful nonparametric multivariate two sample goodness-of-fit test. An extension to this method that makes it possible to perform nonparametric regression using multiple multivariate data sets is presented in this paper. The technique, which is based on the concept of minimizing the energy of the system, permits determination of parameters of interest without the need for parametric expressions of the parent distributions of the data sets. The application and performance of this new method is discussed in the context of some simple example analyses.Comment: 10 pages, 4 figure

Exclusive Lambda_b -> Lambda l^+ l^- decay in two Higgs doublet model

Rare Lambda_b -> Lambda l^+ l^- decay is investigated in framework of general two Higgs doublet model, in which a new source of CP violation exists (model III). The polarization parameter, CP asymmetry and decay width are calculated. It is shown that CP asymmetry is a very sensitive tool for establishing model III.Comment: 16 pages, 3 figures, LaTeX formatte

First determination of the CPCP content of D→π+π−π+π−D \to \pi^+\pi^-\pi^+\pi^- and updated determination of the CPCP contents of D→π+π−π0D \to \pi^+\pi^-\pi^0 and D→K+K−π0D \to K^+K^-\pi^0

Quantum-correlated $\psi(3770) \to D\bar{D}$ decays collected by the CLEO-c experiment are used to perform a first measurement of $F_+^{4\pi}$, the fractional $CP$-even content of the self-conjugate decay $D \to \pi^+\pi^-\pi^+\pi^-$, obtaining a value of $0.737 \pm 0.028$. An important input to the measurement comes from the use of $D \to K^0_{\rm S}\pi^+\pi^-$ and $D \to K^0_{\rm L}\pi^+\pi^-$ decays to tag the signal mode. This same technique is applied to the channels $D \to\pi^+\pi^-\pi^0$ and $D \to K^+K^-\pi^0$, yielding $F_+^{\pi\pi\pi^0} = 1.014 \pm 0.045 \pm 0.022$ and $F_+^{KK\pi^0} = 0.734 \pm 0.106 \pm 0.054$, where the first uncertainty is statistical and the second systematic. These measurements are consistent with those of an earlier analysis, based on $CP$-eigenstate tags, and can be combined to give values of $F_+^{\pi\pi\pi^0} = 0.973 \pm 0.017$ and $F_+^{KK\pi^0} = 0.732 \pm 0.055$. The results will enable the three modes to be included in a model-independent manner in measurements of the unitarity triangle angle $\gamma$ using $B^\mp \to DK^\mp$ decays, and in time-dependent studies of $CP$ violation and mixing in the $D\bar{D}$ system.Comment: Minor revisions following journal acceptanc

New Source of CP violation in B physics ?

In this talk we discuss how the down type left-right squark mixing in Supersymmetry can induce a new source of CP violation in the time dependent asymmtries in B --> phi K process. We use QCD improved factorization process to calculate the hadronic matrix element for the process and find the allowed parameter space for $\rho$ and $\phi$, the magnitude and phase of the down type LR(RL) squark mixing parameter $\delta^{bs}_{LR(RL)}$. In the same allowed regin we calculate the expected CP asymmtries in the $B \to \phi K^{*}$ process.Comment: 16 pages, Latex, 2 postscript figures, invited talk presented by N.G. Deshpande at the 9th Adriatic meeting, Dubrovnik, Croatia, 4-14 September, 2003. With updated reference

Breast Milk Stem Cells: Current Science and Implications for Preterm Infants

Background: The benefits of breast milk are well described, yet the mechanistic details related to how breast milk protects against acute and chronic diseases and optimizes neurodevelopment remain largely unknown. Recently, breast milk was found to contain stem cells that are thought to be involved in infant development. Purpose: The purpose of this review was to synthesize all available research involving the characterization of breast milk stem cells to provide a basis of understanding for what is known and what still needs further exploration. Methods/Search Strategy: The literature search was conducted between August and October 2015 using the CINAHL, PubMed, and reference list searching. Nine studies addressed characterization of human breast milk stem cells. Findings/Results: Five research teams in 4 countries have published studies on breast milk stem cells. Current research has focused on characterizing stem cells in full-term breast milk. The amount, phenotype, and expression of breast milk stem cells are known to vary between mothers, and they have been able to differentiate into all 3 germ layers (expressing pluripotent characteristics). Implications for Practice: There is much to learn about breast milk stem cells. Given the potential impact of this research, healthcare professionals should be aware of their presence and ongoing research to determine benefits for infants. Implications for Research: Extensive research is needed to further characterize stem cells in breast milk (full-term and preterm), throughout the stages of lactation, and most importantly, their role in the health of infants, and potential for use in regenerative therapies

Direct-Breastfeeding in the Neonatal Intensive Care Unit and Breastfeeding Duration for Premature Infants

Aim To explore the relationship between direct-breastfeeding in the neonatal intensive care unit (NICU) and breastfeeding duration after discharge. Background Initiating and maintaining breastmilk feeding is an important goal that begins in the NICU. Little is known about direct-breastfeeding in the NICU and its relation to breastfeeding duration. Methods Chart review of 46 infants (\u3c 32 weeks gestational age or \u3c 1500 grams) whose mothers provided breastmilk. Results One month after discharge, mothers still providing breastmilk were more likely to have provided ≥ 1 direct-breastfeed per day in the NICU (21.16, CI: 3.13–143.25, p \u3c 0.01) and had prior breastfeeding experience (OR: 9.16, CI: 1.02–82.34, p \u3c 0.05). At 4 months, mothers still providing breastmilk were more likely to have provided ≥ 1 direct-breastfeed per day in the NICU (OR: 12.80, CI: 1.39–118.32, p \u3c 0.05). Conclusions Direct-breastfeeding in the NICU may play an essential role in preparing mothers for breastfeeding after discharge, thus potentially impacting breastfeeding duration

Invasive Haemophilus influenzae Disease in Adults ≥65 Years, United States, 2011.

BackgroundSince the introduction of the Haemophilus influenzae serotype b vaccine, H influenzae epidemiology has shifted. In the United States, the largest burden of disease is now in adults aged ≥65 years. However, few data exist on risk factors for disease severity and outcome in this age group.MethodsA retrospective case-series review of invasive H influenzae infections in patients aged ≥65 years was conducted for hospitalized cases reported to Active Bacterial Core surveillance in 2011.ResultsThere were 299 hospitalized cases included in the analysis. The majority of cases were caused by nontypeable H influenzae, and the overall case fatality ratio (CFR) was 19.5%. Three or more underlying conditions were present in 63% of cases; 94% of cases had at least 1. Patients with chronic heart conditions (congestive heart failure, coronary artery disease, and/or atrial fibrillation) (odds ratio [OR], 3.27; 95% confidence interval [CI], 1.65-6.46), patients from private residences (OR, 8.75; 95% CI, 2.13-35.95), and patients who were not resuscitate status (OR, 2.72; 95% CI, 1.31-5.66) were more likely to be admitted to the intensive care unit (ICU). Intensive care unit admission (OR, 3.75; 95% CI, 1.71-8.22) and do not resuscitate status (OR, 12.94; 95% CI, 4.84-34.55) were significantly associated with death.ConclusionsWithin this age group, burden of disease and CFR both increased significantly as age increased. Using ICU admission as a proxy for disease severity, our findings suggest several conditions increased risk of disease severity and patients with severe disease were more likely to die. Further research is needed to determine the most effective approach to prevent H influenzae disease and mortality in older adults

Analysis of B-> \phi K Decays in QCD Factorization

We analyze the decay $B\to \phi K$ within the framework of QCD-improved factorization. We found that although the twist-3 kaon distribution amplitude dominates the spectator interactions, it will suppress the decay rates slightly. The weak annihilation diagrams induced by $(S-P)(S+P)$ penguin operators, which are formally power-suppressed by order $(\Lambda/m_b)^2$, are chirally and logarithmically enhanced. Therefore, these annihilation contributions are not subject to helicity suppression and can be sizable. The predicted branching ratio of $B^-\to\phi K^-$ is $(3.8\pm0.6)\times 10^{-6}$ in the absence of annihilation contributions and it becomes $(4.3^{+3.0}_{-1.4})\times 10^{-6}$ when annihilation effects are taken into account. The prediction is consistent with CLEO and BaBar data but smaller than the BELLE result.Comment: 13 pages, 3 figures. A major change for the presentation of branching-ratio predictions. Experimental data are update

SVD-based Anatomy of Gene Expressions for Correlation Analysis in Arabidopsis thaliana

Gene co-expression analysis has been widely used in recent years for predicting unknown gene function and its regulatory mechanisms. The predictive accuracy depends on the quality and the diversity of data set used. In this report, we applied singular value decomposition (SVD) to array experiments in public databases to find that co-expression linkage could be estimated by a much smaller number of array data. Correlations of co-expressed gene were assessed using two regulatory mechanisms (feedback loop of the fundamental circadian clock and a global transcription factor Myb28), as well as metabolic pathways in the AraCyc database. Our conclusion is that a smaller number of informative arrays across tissues can suffice to reproduce comparable results with a state-of-the-art co-expression software tool. In our SVD analysis on Arabidopsis data set, array experiments that contributed most as the principal components included stamen development, germinating seed and stress responses on leaf

Measurements of |Vub| and |Vcb| from CLEO

I report results from the CLEO collaboration on semileptonic B decays, highlighting measurements of the Cabibbo-Kobayashi-Maskawa matrix elements |Vub| and |Vcb|. I describe the techniques used to obtain the recent improvements in precision for these measurements, notably the use of the b -> s gamma photon spectrum to constrain non-perturbative hadronic effects in semileptonic B decays.Comment: 13 pages, 5 figures, presented at Beauty 200