2 research outputs found
Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis
Objectives:
To investigate a shared genetic aetiology for
skin involvement in psoriasis and psoriatic arthritis (PsA)
by genotyping single-nucleotide polymorphisms (SNPs),
reported to be associated in genome-wide association
studies of psoriasis, in patients with PsA.
Methods:
SNPs with reported evidence for association
with psoriasis were genotyped in a PsA case and control
collection from the UK and Ireland. Genotype and allele
frequencies were compared between PsA cases and
controls using the Armitage test for trend.
Results:
Seven SNPs mapping to the
IL1RN, TNIP1,
TNFAIP3, TSC1, IL23A, SMARCA4
and
RNF114
genes
were successfully genotyped. The
IL23A
and
TNIP1
genes showed convincing evidence for association
(rs2066808, p = 9.1 x 10
?7
; rs17728338, p = 3.5 x
10
?5
, respectively) whilst SNPs mapping to the
TNFAIP3,
TSC1
and
RNF114
genes showed nominal evidence for
association (rs610604, p = 0.03; rs1076160, p = 0.03;
rs495337, p = 0.0025). No evidence for association
with
IL1RN
or
SMARCA4
was found but the power to
detect association was low.
Conclusions:
SNPs mapping to previously reported
psoriasis loci show evidence for association to PSA,
thus supporting the hypothesis that the genetic
aetiology of skin involvement is the same in both PsA
and psoriasi