Effect of Imperceptible Vibratory Noise Applied to Wrist Skin On Fingertip Touch Evoked Potentials – An EEG Study

Random vibration applied to skin can change the sense of touch. Specifically, low amplitude white-noise vibration can improve fingertip touch perception. In fact, fingertip touch sensation can improve even when imperceptible random vibration is applied to other remote upper extremity areas such as wrist, dorsum of the hand, or forearm. As such, vibration can be used to manipulate sensory feedback and improve dexterity, particularly during neurological rehabilitation. Nonetheless, the neurological bases for remote vibration enhanced sensory feedback are yet poorly understood. This study examined how imperceptible random vibration applied to the wrist changes cortical activity for fingertip sensation. We measured somatosensory evoked potentials to assess peak-to-peak response to light touch of the index fingertip with applied wrist vibration versus without. We observed increased peak-to-peak somatosensory evoked potentials with wrist vibration, especially with increased amplitude of the later component for the somatosensory, motor, and premotor cortex with wrist vibration. These findings corroborate an enhanced cortical-level sensory response motivated by vibration. It is possible that the cortical modulation observed here is the result of the establishment of transient networks for improved perception

A mild and efficient approach to enantioenriched α-hydroxyethyl α,β-unsaturated δ-lactams

A straightforward approach toward enantioenriched α-substituted α,β-unsaturated δ-lactams is described. Although a considerable number of approaches toward α,β-unsaturated δ-lactams have been reported, there are relatively few examples of enantioenriched α,δ-disubstituted α,β-unsaturated δ-lactams formation. The δ-stereocenter was formed by addition of allylmagnesium bromide to an N-tert-butylsulfinyl imine. The α,β-unsaturated δ-lactam was furnished by ring-closing metathesis. Although Baylis–Hillman chemistry failed on this cyclic compound, introduction of the hydroxyethyl group prior to ring-closing metathesis was successful. A Baylis–Hillman reaction was used to introduce the substituent at the α-position of the α,β-unsaturated lactam

A Synthetic Strategy toward Eight-Membered Cyclic Amines by Cycloetherification and Claisen Rearrangement

Eight-membered nitrogen-containing heterocycles were straightforwardly produced by a nickel-catalyzed cycloetherification and subsequent Claisen rearrangement of secondary and tertiary alcohols. In particular, a one-pot transformation was achieved with tertiary alcohols in moderate to good yields. This operationally simple reaction is tolerant of many functional groups and applicable to the synthesis of various medium-sized ring nitrogen-containing heterocycles

Back-Translation Practices in Organizational Research: Avoiding Loss in Translation

As organizational research continues to globalize, scholars increasingly must translate established scales into languages other than those in which the scales were originally developed. In organizational psychology research, back-translation is the dominant procedure for translating scales. Back-translation has notable strengths in maintaining the psychometric properties of an established scale in a translated version. However, cross-cultural methodologists have argued that in its most basic form, back-translation often does not result in translations with acceptable levels of equivalence between original and translated research materials. Fortunately, there are complementary procedures to back-translation that can evaluate and strengthen the extent to which scale translations have achieved equivalence between original and translated versions of scales. But how often organizational researchers use and report these procedures in tandem with back-translation is unclear. This article aims to address this lack of clarity by evaluating the state of the use of back-translation in organizational psychology research by reviewing every study in Journal of Applied Psychology that has employed translation over the past nearly 25 years (k = 333). Our findings suggest that the majority of the time that researchers engage in translation procedures, they report having done so. At the same time, the details of these procedures are commonly underreported, making it unclear whether additional techniques beyond back-translation have been used to examine and demonstrate equivalence between original and translated versions of scales. Based on the results of our review, we develop a set of recommendations for conducting and reporting scale translations in organizational research

NRG1 functions downstream of EDS1 to regulate TIR-NLR-mediated plant immunity in Nicotiana benthamiana.

Effector-triggered immunity (ETI) in plants involves a large family of nucleotide-binding leucine-rich repeat (NLR) immune receptors, including Toll/IL-1 receptor-NLRs (TNLs) and coiled-coil NLRs (CNLs). Although various NLR immune receptors are known, a mechanistic understanding of NLR function in ETI remains unclear. The TNL Recognition of XopQ 1 (Roq1) recognizes the effectors XopQ and HopQ1 from Xanthomonas and Pseudomonas, respectively, which activates resistance to Xanthomonas euvesicatoria and Xanthomonas gardneri in an Enhanced Disease Susceptibility 1 (EDS1)-dependent way in Nicotiana benthamiana In this study, we found that the N. benthamiana N requirement gene 1 (NRG1), a CNL protein required for the tobacco TNL protein N-mediated resistance to tobacco mosaic virus, is also essential for immune signaling [including hypersensitive response (HR)] triggered by the TNLs Roq1 and Recognition of Peronospora parasitica 1 (RPP1), but not by the CNLs Bs2 and Rps2, suggesting that NRG1 may be a conserved key component in TNL signaling pathways. Besides EDS1, Roq1 and NRG1 are necessary for resistance to Xanthomonas and Pseudomonas in N. benthamiana NRG1 functions downstream of Roq1 and EDS1 and physically associates with EDS1 in mediating XopQ-Roq1-triggered immunity. Moreover, RNA sequencing analysis showed that XopQ-triggered gene-expression profile changes in N. benthamiana were almost entirely mediated by Roq1 and EDS1 and were largely regulated by NRG1. Overall, our study demonstrates that NRG1 is a key component that acts downstream of EDS1 to mediate various TNL signaling pathways, including Roq1 and RPP1-mediated HR, resistance to Xanthomonas and Pseudomonas, and XopQ-regulated transcriptional changes in N. benthamiana

Catalytic Enantioselective Construction of Quaternary Stereocenters: Assembly of Key Building Blocks for the Synthesis of Biologically Active Molecules

The ever-present demand for drugs with better efficacy and fewer side effects continually motivates scientists to explore the vast chemical space. Traditionally, medicinal chemists have focused much attention on achiral or so-called “flat” molecules. More recently, attention has shifted toward molecules with stereogenic centers since their three-dimensional structures represent a much larger fraction of the chemical space and have a number of superior properties compared with flat aromatic compounds. Quaternary stereocenters, in particular, add greatly to the three-dimensionality and novelty of the molecule. Nevertheless, synthetic challenges in building quaternary stereocenters have largely prevented their implementation in drug discovery. The lack of effective and broadly general methods for enantioselective formation of quaternary stereocenters in simple molecular scaffolds has prompted us to investigate new chemistry and develop innovative tools and solutions. In this Account, we describe three approaches to constructing quaternary stereocenters: nucleophilic substitution of 3-halooxindoles, conjugate addition of boronic acids to cyclic enones, and allylic alkylation of enolates. In the first approach, malonic ester nucleophiles attack electrophilic 3-halooxindoles, mediated by a copper(II)-bisoxazoline catalyst. A variety of oxindoles containing a benzylic quaternary stereocenter can be accessed through this method. However, it is only applicable to the specialized 3,3-disubstituted oxindole system. To access benzylic quaternary stereocenters in a more general context, we turned our attention to the enantioselective conjugate addition of carbon nucleophiles to α,β-unsaturated carbonyl acceptors. We discovered that in the presence of catalytic palladium-pyridinooxazoline complex, arylboronic acids add smoothly to β-substituted cyclic enones to furnish ketones with a β-benzylic quaternary stereocenter in high yields and enantioselectivities. The reaction is compatible with a wide range of arylboronic acids, β-substituents, and ring sizes. Aside from benzylic quaternary stereocenters, a more challenging motif is a quaternary stereocenter not adjacent to an aromatic group. Such centers represent more general structures in chemical space but are more difficult to form by asymmetric catalysis. To address this greater challenge, and motivated by the greater reward, we entered the field of palladium-catalyzed asymmetric allylic alkylation of prochiral enolate nucleophiles about a decade ago. On the basis of Tsuji’s work, which solved the issue of positional selectivity for unsymmetrical ketones, we discovered that the phosphinooxazoline ligand effectively rendered this reaction enantioselective. Extensive investigations since then have revealed that the reaction exhibits broad scope and accepts a range of substrate classes, each with its unique advantage in synthetic applications. A diverse array of carbonyl compounds bearing α-quaternary stereocenters are obtained in excellent yields and enantioselectivities, and more possibilities have yet to be explored. As an alternative to palladium catalysis, we also studied iridium-catalyzed asymmetric allylic alkylations that generate vicinal quaternary and tertiary stereocenters in a single transformation. Overall, these methods provide access to small molecule building blocks with a single quaternary stereocenter, can be applied to various molecular scaffolds, and tolerate a wide range of functional groups. We envision that the chemistry reported in this Account will be increasingly useful in drug discovery and design

Atroposelective Synthesis of PINAP via Dynamic Kinetic Asymmetric Transformation

The atroposelective synthesis of PINAP ligands has been accomplished via a palladium‐catalyzed C−P coupling process through dynamic kinetic asymmetric transformation. These catalytic conditions allow access to a wide variety of alkoxy‐ and benzyloxy‐substituted PINAP ligands in high enantiomeric excess. The methods described in this communication afford valuable P,N ligands in good yields and high enantioselectivity using low catalyst loading

Urban Youth’s Perspectives on Flash Mobs

This is the author's final draft. Copyright 2013 Taylor & Francis.Flash mobs are new, emerging, and evolving social phenomena that have recently been associated with youth violence in U.S. cities. The current study explores how youth understand flash mobs through focus groups conducted in Kansas City, Missouri (a site of violent youth flash mobs). Results indicate that youth have varying familiarity with flash mobs and define them in different ways; that youth perceive youth boredom to be the most frequent cause of problems with flash mobs; that youth connect ongoing social disorder with the violence associated with flash mobs; and that while social media are facilitators of flash mobs, flash mobs have their roots in youth activities that have been going on for generations (e.g., hanging out in groups, cruising)

Assessment Of Streamflow Predictions Generated Using Multimodel And Multiprecipitation Product Forcing

This study assesses streamflow predictions generated by two distributed hydrologic models, the Hillslope Link Model (HLM) and the National Water Model (NWM), driven by three radar-based precipitation forcing datasets. These forcing data include the Multi-Radar Multi-Sensor (MRMS), and the Iowa Flood Center\u27s single-polarization-based (IFC-SP) and dual-polarization-based (IFC-DP) products. To examine forcing-and model-dependent aspects of the representation of hydrologic processes, we mixed and matched all forcing data and models, and simulated streamflow for 2016–18 based on six forcing–model combinations. The forcing product evaluation using independent ground reference data showed that the IFC-DP radar-only product\u27s accuracy is comparable to MRMS, which is rain gauge corrected. Streamflow evaluation at 140 U.S. Geological Survey (USGS) stations in Iowa demonstrated that the HLM tended to perform slightly better than the NWM, generating streamflow with smaller volume errors and higher predictive power as measured by Kling–Gupta efficiency (KGE). The authors also inspected the effect of estimation errors in the forcing products on streamflow generation and found that MRMS\u27s slight underestimation bias led to streamflow underestimation for all simulation years, particularly with the NWM. The less biased product (IFC-DP), which has higher error variability, resulted in increased runoff volumes with larger dispersion of errors compared to the ones derived from MRMS. Despite its tendency to underestimate, MRMS showed consistent performance with lower error variability as reflected by the KGE. The dispersion observed from the evaluation metrics (e.g., volume error and KGE) seems to decrease as scale becomes larger, implying that random errors in forcing are likely to average out at larger-scale basins. The evaluation of simulated peaks revealed that an accurate estimation of peak (e.g., time and magnitude) remains challenging, as demonstrated by the highly scattered distribution of peak errors for both hydrologic models