22 research outputs found
Manufacturing Supervisors And Conflicting Demands: Determining Supervisor Behaviors That Meet The Expectations Of The Plant Manager And Employees
Bystanders' reactions towards co-punishment events in the Taiwanese military: Examining the moderating effects of organizational norms
Do Substitutes for Leadership Really Substitute for Leadership? An Empirical Examination of Kerr and Jermier's Situational Leadership Model
Organizational Citizenship Behaviors: Their Relationship to Organizational Effectiveness
The Mediating Effects of Interactional Injustice on the Relationship between Face-Threatening Behavior of Supervisors and Organizational Silence
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New directions in clinical trials for frontotemporal lobar degeneration: Methods and outcome measures.
IntroductionFrontotemporal lobar degeneration (FTLD) is the most common form of dementia for those under 60 years of age. Increasing numbers of therapeutics targeting FTLD syndromes are being developed.MethodsIn March 2018, the Association for Frontotemporal Degeneration convened the Frontotemporal Degeneration Study Group meeting in Washington, DC, to discuss advances in the clinical science of FTLD.ResultsChallenges exist for conducting clinical trials in FTLD. Two of the greatest challenges are (1) the heterogeneity of FTLD syndromes leading to difficulties in efficiently measuring treatment effects and (2) the rarity of FTLD disorders leading to recruitment challenges.DiscussionNew personalized endpoints that are clinically meaningful to individuals and their families should be developed. Personalized approaches to analyzing MRI data, development of new fluid biomarkers and wearable technologies will help to improve the power to detect treatment effects in FTLD clinical trials and enable new, clinical trial designs, possibly leveraged from the experience of oncology trials. A computational visualization and analysis platform that can support novel analyses of combined clinical, genetic, imaging, biomarker data with other novel modalities will be critical to the success of these endeavors