Supporting Information: AT1R biased signaling by cyclic Angiotensin II analogs (St-Pierre et al., Biochem Pharmacol, 2018)

Supporting Information of the following article:<div><pre>David St-Pierre, <i>et al.</i> <b>Angiotensin II cyclic analogs as tools to investigate AT₁R biased signaling mechanisms.</b> <i>Biochemical Pharmacology.</i> Available online 20 April 2018. https://doi.org/10.1016/j.bcp.2018.04.021</pre><div><u>File content:</u></div><div><div><div><div><p>Structure of compounds<br>UPLC-MS and MS spectra of compounds</p></div></div></div></div></div

Synthesis and Evaluation of a ⁶⁴Cu-Conjugate, a Selective δ‑Opioid Receptor Positron Emission Tomography Imaging Agent

Given the putative selectivity of the antagonist TIPP (Tyr-Tic-Phe-Phe) for δ-opioid receptors (DOP), this compound was selected for the design of a novel ⁶⁴Cu-radiolabeled potent and selective DOP positron emission tomography (PET) imaging agent. <i>Ex vivo</i> autoradiography of TIPPD-PEG-K­(NOTA/⁶⁴Cu)-NH₂ on rat brain sections produced a distribution pattern consistent with the known expression of DOP. Taken together, the <i>in vitro</i> and <i>ex vivo</i> data indicate that this ⁶⁴Cu-tracer holds promise for studying the DOP by means of PET