Development of the linear gridless ion thruster

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/77069/1/AIAA-2001-3649-323.pd

Plasma properties downstream of a low-power Hall thruster

Triple Langmuir probes and emissive probes were used to measure the electron number density, electron temperature, and plasma potential downstream of a low-power Hall thruster. The results show a polytropic relation between electron temperature and electron number density throughout the sampled region. Over a large fraction of the plume, the plasma potential obeys the predictions of ambipolar expansion. Near the thruster centerline, however, observations show larger gradients of plasma potential than can be accounted for by this means. Radial profiles of plasma potential in the very-near-field plume are shown to contain large gradients that correspond in location to the boundaries of a visually intense plasma region.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87761/2/123503_1.pd

The Effects of Cathode Configuration on Hall Thruster Cluster Plume Properties

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76110/1/AIAA-2005-3678-895.pd

Preliminary Plume Characterization of a Low-Power Hall Thruster Cluster

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76481/1/AIAA-2002-4251-381.pd

Plasma Properties in the Plume of a Hall Thruster Cluster

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76225/1/AIAA-3765-486.pd

Effects of Cathode Configuration on Hall Thruster Cluster Plume Properties

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76620/1/AIAA-24636-518.pd

High throughput methodology for synthesis, screening, and optimization of solid state Lithium ion electrolytes

A study of the lithium ion conductor Li3xLa2/3–xTiO3 solid solution and the surrounding composition space was carried out using a high throughput physical vapor deposition system. An optimum total ionic conductivity value of 5.45 × 10–4 S cm–1 was obtained for the composition Li0.17La0.29Ti0.54 (Li3xLa2/3–xTiO3x = 0.11). This optimum value was calculated using an artificial neural network model based on the empirical data. Due to the large scale of the data set produced and the complexity of synthesis, informatics tools were required to analyze the data. Partition analysis was carried out to determine the synthetic parameters of importance and their threshold values. Multivariate curve resolution and principal component analysis were applied to the diffraction data set. This analysis enabled the construction of phase distribution diagrams, illustrating both the phases obtained and the compositional zones in which they occur. The synthetic technique presented has significant advantages over other thin film and bulk methodologies, in terms of both the compositional range covered and the nature of the materials produce

Development of an Annular Helicon Source for Electric Propulsion Applications

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76441/1/AIAA-2006-4841-172.pd

The State of Coral Reef Ecosystems of Southeast Florida

The northern extension of the Florida reef tract and a complex of limestone ridges run parallel to the subtropical Atlantic coastline of southeast Florida. Spanning 170 km from the northern border of Biscayne National Park (BNP) in Miami-Dade County to the St. Lucie Inlet in Martin County, the reefs and hardbottom areas in this region support a rich and diverse biological community (Figure 5.1). Nearshore reef habitats in southeast Florida include hardbottom areas, patch reefs and worm reefs (Phragmatopoma spp.) exhibiting abundant octocoral, macroalgae, stony coral and sponge assemblages. Offshore, coral reef associated biotic assemblages occur on linear Holocene Acropora palmata mid-shelf and shelf margin reefs that extend from Miami Dade County to Palm Beach County (Lighty, 1977; Figure 5.2). Anastasia Formation limestone ridges and terraces colonized by reef biota characterize the reefs from Palm Beach County to Martin County (Cooke and Mossom, 1929). The coastal region of southeast Florida is highly developed, containing one third of Florida’s population of 16 million people (U.S. Census Bureau, 2006). Many southeast Florida reefs are located just 1.5 km from this urbanized shoreline. Despite their unique position as the highest latitude reefs along the western Atlantic seaboard, the reefs of southeast Florida have only recently received limited scientific and resource management attention. Andrews et al. (2005) discussed the reefs of southeast Florida and the critical need to implement actions that fill resource knowledge gaps and address conservation and threats to reef health. This report further examines and updates the list of stressors imperiling the health of southeast Florida’s reefs, and presents information gained from new research, monitoring and management efforts to determine the extent and condition of reef resources in this distinctive region

TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson's Disease.

Alpha-synuclein (α-Syn) accumulation/aggregation and mitochondrial dysfunction play prominent roles in the pathology of Parkinson's disease. We have previously shown that postmortem human dopaminergic neurons from PD brains accumulate high levels of mitochondrial DNA (mtDNA) deletions. We now addressed the question, whether alterations in a component of the mitochondrial import machinery -TOM40- might contribute to the mitochondrial dysfunction and damage in PD. For this purpose, we studied levels of TOM40, mtDNA deletions, oxidative damage, energy production, and complexes of the respiratory chain in brain homogenates as well as in single neurons, using laser-capture-microdissection in transgenic mice overexpressing human wildtype α-Syn. Additionally, we used lentivirus-mediated stereotactic delivery of a component of this import machinery into mouse brain as a novel therapeutic strategy. We report here that TOM40 is significantly reduced in the brain of PD patients and in α-Syn transgenic mice. TOM40 deficits were associated with increased mtDNA deletions and oxidative DNA damage, and with decreased energy production and altered levels of complex I proteins in α-Syn transgenic mice. Lentiviral-mediated overexpression of Tom40 in α-Syn-transgenic mice brains ameliorated energy deficits as well as oxidative burden. Our results suggest that alterations in the mitochondrial protein transport machinery might contribute to mitochondrial impairment in α-Synucleinopathies