Additional file 2: of Markov State Models of gene regulatory networks

Contains the scripts used to produce the figures and tables. (ZIP 76 kb

Cost comparison between previous PDA system and LINKS.

<p>Cost comparison between previous PDA system and LINKS.</p

Implementation of LINKS system from June 2011–Aug 2013.

<p>Implementation of LINKS system from June 2011–Aug 2013.</p

LINKS system technology overview.

<p>Data flow from the point of entry (cellular phones/tablets), to encrypted transmission to the cloud, to access and management of the data through a web interface.</p

Additional file 1: of Markov State Models of gene regulatory networks

Supporting Information. Description of data: Explains models and algorithms used as well as supporting tables and figures. (PDF 5439 kb

Interview results.

<p>Interview results.</p

Additional file 1: of The health and economic benefits of the global programme to eliminate lymphatic filariasis (2000–2014)

Multilingual abstract in the five official working languages of the United Nations. (PDF 323 kb

Additional file 2: Table S1. of The health and economic benefits of the global programme to eliminate lymphatic filariasis (2000–2014)

The breakdown of where individuals receive treatment. Table S2. Regional specific patient medical expenses and health system costs. Table S3. DALYs averted stratified by WHO region. Table S4. Economic benefits for individuals and the health systems stratified by the WHO regions. Table S5. Impact of the sensitivity analysis on the projected health benefits of the GPELF (2000–2014). Table S6. Impact of the sensitivity analysis on the projected economic benefits of the GPELF (2000–2014). (DOCX 28 kb

Successful Control of Soil-Transmitted Helminthiasis in School Age Children in Burkina Faso and an Example of Community-Based Assessment via Lymphatic Filariasis Transmission Assessment Survey

<div><p>Background</p><p>Burkina Faso is endemic with soil-transmitted helminth infections. Over a decade of preventive chemotherapy has been implemented through annual lymphatic filariasis (LF) mass drug administration (MDA) for population aged five years and over, biennial treatment of school age children with albendazole together with schistosomiasis MDA and biannual treatment of pre-school age children through Child Health Days. Assessments were conducted to evaluate the current situation and to determine the treatment strategy for the future.</p><p>Methodology/Principal Findings</p><p>A cross-sectional assessment was conducted in 22 sentinel sites across the country in 2013. In total, 3,514 school age children (1,748 boys and 1,766 girls) were examined by the Kato-Katz method. Overall, soil-transmitted helminth prevalence was 1.3% (95% CI: 1.0–1.8%) in children examined. Hookworm was the main species detected, with prevalence of 1.2% (95% CI: 0.9–1.6%) and mean egg counts of 2.1 epg (95% CI: 0–4.2 epg). Among regions, the Centre Ouest region had the highest hookworm prevalence of 3.4% (95% CI: 1.9–6.1%) and mean egg counts of 14.9 epg (95% CI: 3.3–26.6 epg). A separate assessment was conducted in the Centre Nord region in 2014 using community-based cluster survey design during an LF transmission assessment survey (TAS). In this assessment, 351 children aged 6–7 years and 345 children aged 10–14 years were examined, with two cases (0.6% (95% CI: 0.2–2.1%)) and seven cases (2.0% (95% CI: 1.0–4.1%)) of hookworm infection was identified respectively. The results using both age groups categorized the region to be 2% to <10% in STH prevalence according to the pre-defined cut-off values.</p><p>Conclusions/Significance</p><p>Through large-scale preventive chemotherapy, Burkina Faso has effectively controlled STH in school age children in the country. Research should be conducted on future strategies to consolidate the gain and to interrupt STH transmission in Burkina Faso. It is also demonstrated that LF TAS provides one feasible and efficient platform to assess the STH situation for post LF MDA decision making.</p></div

Distribution of positive STH cases in surveyed clusters in the Centre Nord EU from the LF TAS-STH assessment in 2014.

<p>A) 6–7 years old, B) 10–14 years old.</p