Figure 7

<p>The relative effect of hydration, defatting and particle size on the extent of prion surrogate degradation (n = 3, each data point; error bars represent ±1 standard deviation).</p

Reaction and analysis solutions

<p>Reaction and analysis solutions</p

Figure 5

<p>SDS-PAGE. Lane 1 is crude Versazyme™, lane 2 is extract from MBM incubated without Versazyme™, lane 3 is extract from MBM incubated with Versazyme™. Arrow indicates band chosen as prion surrogate.</p

Figure 6

<p>The effect of tissue type on the extent of prion surrogate degradation (n = 3, each data point; error bars represent ±1 standard deviation).</p

Figure 3

<p>Penetration of fluorescently labeled Versazyme™ (represented by red color) into a bone particle, after 10 minutes incubation. Arrow indicates a fissure in the particle. White bar is 25 µm.</p

Figure 4

<p>The increase in the solubility of MBM protein as proteolytic digestion progresses. Open symbols represent control experiment with Versazyme™ omitted, closed symbols represent experiment with Versazyme™ (n = 2, each data point; error bars represent ±1 standard deviation).</p

Figure 1

<p>Representative MBM particles autofluorescing. Particles in top row are soft tissue, particles in bottom row are bone. Arrows indicate ‘fissures’; white bar is 25 µm.</p