Case study : a patient-clinician collaboration that identified and prioritized evidence gaps and stimulated research development

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The Bull's-Eye Effect as a Probe of Ω\Omega

We compare the statistical properties of structures normal and transverse to the line of sight which appear in theoretical N-body simulations of structure formation, and seem also to be present in observational data from redshift surveys. We present a statistic which can quantify this effect in a conceptually different way from standard analyses of distortions of the power-spectrum or correlation function. From tests with $N$--body experiments, we argue that this statistic represents a new and potentially powerful diagnostic of the cosmological density parameter, $\Omega_0$.Comment: Minor revisions; final version accepted for publication in ApJ Letters. Latex, 16 pages, including 3 figures. Higher resolution versions of figures, including supplementary figures not included in the manuscript, are available at: ftp://kusmos.phsx.ukans.edu/preprints/melott/omeg

Quantifying the Bull's Eye Effect

We have used N-body simulations to develop two independent methods to quantify redshift distortions known as the Bull's Eye effect (large scale infall plus small scale virial motion). This effect depends upon the mass density, $\Omega_0$, so measuring it can in principle give an estimate of this important cosmological parameter. We are able to measure the effect and distinguish between its strength for high and low values of $\Omega_0$. Unlike other techniques which utilize redshift distortions, one of our methods is relatively insensitive to bias. In one approach, we use path lengths between contour crossings of the density field. The other is based upon percolation. We have found both methods to be successful in quantifying the effect and distinguishing between values of $\Omega_0$. However, only the path lengths method exhibits low sensitivity to bias.Comment: 21 pages, 5 figures, 3 tables; Replaced version - minor corrections, replaced figure 2; To appear in ApJ, Jan. 20, 200

Shape and deformation measurement using heterodyne range imaging technology

Range imaging is emerging as a promising alternative technology for applications that require non-contact visual inspection of object deformation and shape. Previously, we presented a solid-state full-field heterodyne range imaging device capable of capturing three-dimensional images with sub-millimetre range resolution. Using a heterodyne indirect time-of-flight configuration, this system simultaneously measures distance (and intensity), for each pixel in a cameras field of view. In this paper we briefly describe our range imaging system, and its principle of operation. By performing measurements on several metal objects, we demonstrate the potential capabilities of this technology for surface profiling and deformation measurement. In addition to verifying system performance, the reported examples highlight some important system limitations. With these in mind we subsequently discuss the further developments required to enable the use of this device as a robust and practical tool in non-destructive testing and measurement applications

Advantages of 3D time-of-flight range imaging cameras in machine vision applications

Machine vision using image processing of traditional intensity images is in wide spread use. In many situations environmental conditions or object colours or shades cannot be controlled, leading to difficulties in correctly processing the images and requiring complicated processing algorithms. Many of these complications can be avoided by using range image data, instead of intensity data. This is because range image data represents the physical properties of object location and shape, practically independently of object colour or shading. The advantages of range image processing are presented, along with three example applications that show how robust machine vision results can be obtained with relatively simple range image processing in real-time applications

Calibration and control of a robot arm using a range imaging camera

Time of flight range imaging is an emerging technology that has numerous applications in machine vision. In this paper we cover the use of a commercial time of flight range imaging camera for calibrating a robotic arm. We do this by identifying retro-reflective targets attached to the arm, and centroiding on calibrated spatial data, which allows precise measurement of three dimensional target locations. The robotic arm is an inexpensive model that does not have positional feedback, so a series of movements are performed to calibrate the servos signals to the physical position of the arm. The calibration showed a good linear response between the control signal and servo angles. The calibration procedure also provided a transformation between the camera and arm coordinate systems. Inverse kinematic control was then used to position the arm. The range camera could also be used to identify objects in the scene. With the object location now known in the arm's coordinate system (transformed from the camera's coordinate system) the arm was able to move allowing it to grasp the object

Dorsal striatum mediates cognitive control, not cognitive effort per se, in decision-making: An event-related fMRI study

Objective: Whether the dorsal striatum (DS) mediates cognitive control or cognitive effort per se in decision-making is unclear given that these effects are highly correlated. As the cognitive control requirements of a neuropsychological task intensify, cognitive effort increases proportionately. We implemented a task that disentangled cognitive control and cognitive effort to specify the particular function DS mediates in decision-making. Methods: Sixteen healthy young adults completed a number Stroop task with simultaneous blood-oxygenation-level-dependent response (BOLD) measurement using functional magnetic resonance imaging. Participants selected the physically larger number of a pair of single-digit integers. Discriminating smaller versus larger physical size differences between a number pair requires greater cognitive effort, but does not require greater cognitive control. We also investigated the effect of conflict between the physical and numerical dimensions of targets (e.g., 2 6). Selections in this incongruent case are more cognitively effortful and require greater cognitive control to suppress responding to the irrelevant dimension. Enhancing cognitive effort or cognitive control demands increases errors and response times. Despite similar behavioural profiles, our aim was to determine whether DS mediates cognitive control or simply indexes cognitive effort, using the same data set. Results: As expected, behavioural interference effects occurred for both enhanced cognitive control and/or cognitive effort conditions. Despite similar degrees of behavioural interference, DS BOLD signal only correlated with interference arising due to increased cognitive control demands in the incongruent case. DS was not preferentially activated for discriminations of smaller relative to larger physical size differences between number pairs, even when using liberal statistical criteria. However, our incongruent and physical size effects conjointly activated regions related to effortful processing (e.g., anterior cingulate cortex). Interpretation: We interpret these findings as support for the increasingly accepted notion that DS mediates cognitive control specifically and does not simply index cognitive effort per se

Mantle sources and magma evolution in Europe's largest rare earth element belt (Gardar Province, SW Greenland) : new insights from sulfur isotopes

This work is a contribution to the HiTech AlkCarb project and was funded by the European Union's Horizon 2020 research and innovation programme under grant agreement No. 689909. W.H. also acknowledges support from a UKRI Future Leaders Fellowship (MR/S033505/1). A.J.B. is funded by the NERC National Environment Isotope Facility award (NE/S011587/1) and the Scottish Universities Environmental Research Centre.Alkaline igneous complexes are often rich in rare earth elements (REE) and other metals essential for modern technologies. Although a variety of magmatic and hydrothermal processes explain the occurrence of individual deposits, one common feature identified in almost all studies, is a REE-enriched parental melt sourced from the lithospheric mantle. Fundamental questions remain about the origin and importance of the mantle source in the genesis of REE-rich magmas. In particular, it is often unclear whether localized enrichments within an alkaline province reflect heterogeneity in the mantle source lithology (caused by prior subduction or plume activity) or variations in the degree of partial melting and differentiation of a largely homogeneous source. Sulfur isotopes offer a means of testing these hypotheses because they are unaffected by high temperature partial melting processes and can fingerprint different mantle sources. Although one must be careful to rule out subsequent isotope fractionation during magma ascent, degassing and crustal interactions. Here, we present new S concentration and isotope (δ34S) measurements, as well as a compilation of major and trace element data, for a suite of alkaline magmatic units and crustal lithologies from the Mesoproterozoic Gardar Province. Samples span all phases of Gardar magmatism (1330–1140 Ma) and include regional dykes, rift lavas and the alkaline complexes Motzfeldt and Ilímaussaq, which represent two of Europe's largest REE deposits. We show that the vast majority of our 115 samples have S contents >100 ppm and δ34S of −1 to 5‰. Only 8 samples (with low S contents, <100 ppm) show evidence for crustal interactions, implying that the vast majority of Gardar melts preserve the S isotopic signature of their magma source. Importantly, samples from across the Gardar Province δ34S have above the canonical mantle range (≤−1.4‰) and therefore require recycled surface S in their mantle source. Elevated values are explained by a period of Andean-style subduction and mantle metasomatism which took place ∼500 Ma before rift onset and are also supported by trace elements signatures (e.g. Ba/La) which match modern subduction zones. Comparing the various generations of Gardar magmas, we find that δ34S  values, large ion lithophile elements (K, Ba, P) and selective incompatible elements (Nb and light REE) are particularly enriched in the Late Gardar dykes, alkaline complexes and clusters of silica-undersaturated dykes spatially associated with the alkaline complexes. These data indicate that subduction-related metasomatism of the Gardar mantle was spatially heterogeneous, and that alkaline complexes are sourced from localized mantle domains highly enriched in 34S, REE, alkalis and volatiles (particularly, F). Since alkalis and volatiles play an essential role in driving extreme differentiation of alkaline melts and fluids, we suggest the co-location of these species plus incompatible metals at high concentrations in the lithospheric mantle is a critical first-step in the genesis of a world-class alkaline REE deposit. S isotopes are powerful tools for identifying enriched mantle domains and the sources of mineralized alkaline igneous bodies.Publisher PDFPeer reviewe

Astrophysical Ionizing Radiation and the Earth: A Brief Review and Census of Intermittent Intense Sources

Cosmic radiation backgrounds are a constraint on life, and their distribution will affect the Galactic Habitable Zone. Life on Earth has developed in the context of these backgrounds, and characterizing event rates will elaborate the important influences. This in turn can be a base for comparison with other potential life-bearing planets. In this review we estimate the intensities and rates of occurrence of many kinds of strong radiation bursts by astrophysical entities ranging from gamma-ray bursts at cosmological distances to the Sun itself. Many of these present potential hazards to the biosphere: on timescales long compared with human history, the probability of an event intense enough to disrupt life on the land surface or in the oceans becomes large. We enumerate the known sources of radiation and characterize their intensities at the Earth and rates or upper limits on these quantities. When possible, we estimate a "lethal interval", our best estimate of how often a major extinction-level event is probable given the current state of knowledge; we base these estimates on computed or expected depletion of stratospheric ozone. In general, moderate level events are dominated by the Sun, but the far more severe infrequent events are probably dominated by gamma-ray bursts and supernovae. We note for the first time that so-called "short-hard" gamma-ray bursts are a substantial threat, comparable in magnitude to supernovae and greater than that of the higher-luminosity long bursts considered in most past work. Given their precursors, short bursts may come with little or no warning.Comment: to be published in Astrobiolog