1 research outputs found
Allyl-Assisted, Cu(I)-Catalyzed Azide–Alkyne Cycloaddition/Allylation Reaction: Assembly of the [1,2,3]Triazolo-4,5,6,7-tetrahydropyridine Core Structure
We report a Cu(I)-catalyzed azide–alkyne–allyl
halide
three-component reaction for a one-pot synthesis of 1,4-disubstituted
5-allyl-1,2,3-triazoles. The allyl moiety provides not only the electrophile
but also a coordinating ligand to Cu, which is essential for the reaction
to occur under mild conditions. A concise synthesis of a potential
drug candidate <b>1</b> is realized based on this key reaction