In with the Old, Out with the New

Michael Cohen, Maria Figueroa Küpçü and Parag Khanna make some compelling arguments about the inherent drawbacks regarding the role diverse networks of NGOs play in keeping at-risk populations alive throughout the world. We are informed that these groups are “the new colonialists,” agencies much like the old European empires. These new colonialists are apparently enforcing a cycle of dependency which prevents the development of state structures, structures that apparently sustain these populations more effectively. The problem with this thesis is that the authors do not seem to entertain the possibility that the nation-state is itself an (old) colonial construct, and that even the longing for the “strong” structures of the nation-state in these at-risk areas represents, at least implicitly, a somewhat outdated way of thinking

Human Rights and the 2008 U.S. Presidential Election

There has been a vivid tendency this year by the conventional keepers of Washington wisdom to explicate the two presidential candidates\u27 foreign policy views using old frameworks of hawk and dove. Not only is this binary wrong, it fundamentally obscures some rather ironic potentials for how each candidate, if elected president, will focus upon human rights in their foreign policy. McCain\u27s neoconservative view of the world is founded upon the Wilsonian call for democratization-culminating in what he terms a League of Democracies. To use a concept that Arnold Wolfers first coined, and one which Joshua Muravchik has proffered as well, McCain has at heart milleu goals for the world. The U.S.\u27s prominent position as a great power can not only secure American national interests in anarchy, it can change that notion of anarchy altogether - a world constituted by liberal democracies is one which will be radically more peaceful than one where rogue states reside

Reforming Humanitarian Rescue

There is much to commend in Morton Abramowitz and Thomas Pickering’s article “Making Intervention Work.” They propose to reform the United Nations’ capacity for intervention with the creation of an autonomous U.N. force largely constituted with forces contributed by the Security Council’s member-states. If such a force were kept to a minimal operational mission, “a small rapid-deployment force with special engineering, logistical, medical, and police skills,” as the authors suggest, then I think this is a good idea. If such a force would, however, become more than this—an autonomous army of military personnel meant to intervene with force into any humanitarian crisis in which it is needed or sanctioned—then I fear this would be a counter-productive entity

Ontological insecurities and the politics of contemporary populism

The loss of faith in mainstream political parties and moderate electoral candidates seems characteristic of the zeitgeist in much of the Western world and beyond. Whether in the form of the United Kingdom’s vote to exit the European Union (EU), the 2016 United States (US) presidential election of the Republican nominee Donald Trump, the prior strength of Senator Bernie Sandecrs within the Democratic party primaries, or the rise of the anti-neoliberal left alongside resurgent rightist anti-migration groups in Europe, varieties of populism have gravitated from the fringes of politics into the center. They have gained traction in tandem with widespread perceptions of crises, insecurity and alienation as markers of a ‘runaway world’ whose forces lie beyond the control of the many (Giddens 1999)

Critical security history : (de)securitisation, ontological security and insecure memories

This article makes a case for incorporating the concept of ‘Critical Security History’ (CSH) into security studies. While history plays a powerful role in a cornucopia of security stories, we contend that it often goes unnoticed in scholarly research and teaching. Against this backdrop, we present a detailed guide to study how history is told and enacted in non-linear ways. To do this, the article outlines how CSH can contribute to securitisation and ontological security studies. As shown, this lens casts a new light on the legacies of (de)securitisation processes and how they are commemorated. It also illustrates that ontological security studies have only begun to call into question the concept of historicity. Working through these observations, the article marshals insights from Halvard Leira's notion of ‘engaged historical amateurism’ to entice scholars interested in ‘doing’ CSH. While acknowledging that this research agenda is hard to achieve, our study of the 2012 Sarajevo Red Line project helps to illustrate the added value of trying to ‘do’ CSH in theory and in practice. We end with some reflections for future research and continued conversations.PostprintPeer reviewe

Child's play:Temporal discourse, counterpower, and environmental politics

No abstract available

Genome-wide imputation study identifies novel HLA locus for pulmonary fibrosis and potential role for auto-immunity in fibrotic idiopathic interstitial pneumonia.

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access.Fibrotic idiopathic interstitial pneumonias (fIIP) are a group of fatal lung diseases with largely unknown etiology and without definitive treatment other than lung transplant to prolong life. There is strong evidence for the importance of both rare and common genetic risk alleles in familial and sporadic disease. We have previously used genome-wide single nucleotide polymorphism data to identify 10 risk loci for fIIP. Here we extend that work to imputed genome-wide genotypes and conduct new RNA sequencing studies of lung tissue to identify and characterize new fIIP risk loci.We performed genome-wide genotype imputation association analyses in 1616 non-Hispanic white (NHW) cases and 4683 NHW controls followed by validation and replication (878 cases, 2017 controls) genotyping and targeted gene expression in lung tissue. Following meta-analysis of the discovery and replication populations, we identified a novel fIIP locus in the HLA region of chromosome 6 (rs7887 P meta  = 3.7 × 10(-09)). Imputation of classic HLA alleles identified two in high linkage disequilibrium that are associated with fIIP (DRB1*15:01 P = 1.3 × 10(-7) and DQB1*06:02 P = 6.1 × 10(-8)). Targeted RNA-sequencing of the HLA locus identified 21 genes differentially expressed between fibrotic and control lung tissue (Q < 0.001), many of which are involved in immune and inflammatory response regulation. In addition, the putative risk alleles, DRB1*15:01 and DQB1*06:02, are associated with expression of the DQB1 gene among fIIP cases (Q < 1 × 10(-16)).We have identified a genome-wide significant association between the HLA region and fIIP. Two HLA alleles are associated with fIIP and affect expression of HLA genes in lung tissue, indicating that the potential genetic risk due to HLA alleles may involve gene regulation in addition to altered protein structure. These studies reveal the importance of the HLA region for risk of fIIP and a basis for the potential etiologic role of auto-immunity in fIIP.National Heart, Lung and Blood Institute R01-HL095393 R01-HL097163 P01-HL092870 RC2-HL101715 U01-HL089897 U01-HL089856 U01-HL108642 P50-HL089493

Cause of Cambrian Explosion - Terrestrial or Cosmic?

We review the salient evidence consistent with or predicted by the Hoyle-Wickramasinghe (H-W) thesis of Cometary (Cosmic) Biology. Much of this physical and biological evidence is multifactorial. One particular focus are the recent studies which date the emergence of the complex retroviruses of vertebrate lines at or just before the Cambrian Explosion of ∼500 Ma. Such viruses are known to be plausibly associated with major evolutionary genomic processes. We believe this coincidence is not fortuitous but is consistent with a key prediction of H-W theory whereby major extinction-diversification evolutionary boundaries coincide with virus-bearing cometary-bolide bombardment events. A second focus is the remarkable evolution of intelligent complexity (Cephalopods) culminating in the emergence of the Octopus. A third focus concerns the micro-organism fossil evidence contained within meteorites as well as the detection in the upper atmosphere of apparent incoming life-bearing particles from space. In our view the totality of the multifactorial data and critical analyses assembled by Fred Hoyle, Chandra Wickramasinghe and their many colleagues since the 1960s leads to a very plausible conclusion - life may have been seeded here on Earth by life-bearing comets as soon as conditions on Earth allowed it to flourish (about or just before 4.1 Billion years ago); and living organisms such as space-resistant and space-hardy bacteria, viruses, more complex eukaryotic cells, fertilised ova and seeds have been continuously delivered ever since to Earth so being one important driver of further terrestrial evolution which has resulted in considerable genetic diversity and which has led to the emergence of mankind