2 research outputs found
Fractal and multifractal analysis of PET-CT images of metastatic melanoma before and after treatment with ipilimumab
PET/CT with F-18-Fluorodeoxyglucose (FDG) images of patients suffering from
metastatic melanoma have been analysed using fractal and multifractal analysis
to assess the impact of monoclonal antibody ipilimumab treatment with respect
to therapy outcome. Our analysis shows that the fractal dimensions which
describe the tracer dispersion in the body decrease consistently with the
deterioration of the patient therapeutic outcome condition. In 20 out-of 24
cases the fractal analysis results match those of the medical records, while 7
cases are considered as special cases because the patients have non-tumour
related medical conditions or side effects which affect the results. The
decrease in the fractal dimensions with the deterioration of the patient
conditions (in terms of disease progression) are attributed to the hierarchical
localisation of the tracer which accumulates in the affected lesions and does
not spread homogeneously throughout the body. Fractality emerges as a result of
the migration patterns which the malignant cells follow for propagating within
the body (circulatory system, lymphatic system). Analysis of the multifractal
spectrum complements and supports the results of the fractal analysis. In the
kinetic Monte Carlo modelling of the metastatic process a small number of
malignant cells diffuse throughout a fractal medium representing the blood
circulatory network. Along their way the malignant cells engender random
metastases (colonies) with a small probability and, as a result, fractal
spatial distributions of the metastases are formed similar to the ones observed
in the PET/CT images. In conclusion, we propose that fractal and multifractal
analysis has potential application in the quantification of the evaluation of
PET/CT images to monitor the disease evolution as well as the response to
different medical treatments.Comment: 38 pages, 9 figure
Ανάπτυξη παιχνιδιού για την αξιολόγηση της κουλτούρας των εργαζόμενων σχετικά με την ασφάλεια των πληροφοριακών συστημάτων σε έναν οργανισμό
Εθνικό Μετσόβιο Πολυτεχνείο--Μεταπτυχιακή Εργασία. Διεπιστημονικό-Διατμηματικό Πρόγραμμα Μεταπτυχιακών Σπουδών (Δ.Π.Μ.Σ.) “Τεχνο-Οικονομικά Συστήματα (ΜΒΑ)