Statistical nature of secondary electron emission

The energy-dependence of the secondary electron yield by electron impact on clean materials is shown, through comparisons with both experimental data and previous semi-empirical models, to be described well by a log-normal distribution. The maximum yield and corresponding energy are calculated in terms of the fit parameters. The function also agrees with the ‘universal curve’ obtained by expressing the experimental data in terms of the position and magnitude of maximum yield. The positron- and ion-induced secondary electron yields also exhibit a log-normal dependence and this is used to extend their energy ranges without prior knowledge of the position and magnitude of their maxima. In addition to their intrinsic usefulness, the results provide further support for the statistical description of inelastic processes advanced by Laricchia et al. (2018)

Absolute differential positronium-formation cross sections

The first absolute experimental determinations of the differential cross-sections for the formation of ground-state positronium are presented for He, Ar, H2 and CO2 near 0○. Results are compared with available theories. The ratio of the differential and integrated cross-sections for the targets exposes the higher propensity for forward-emission of positronium formed from He and H2

Resonant Scattering of Positronium in Collision with CO2

The total cross sections of positronium (Ps) scattering from a carbon-dioxide molecule have been measured over the range (7-400) eV incident-Ps energy. For the first time in Ps collisions, a resonantlike structure is observed. For the present target, it occurs around 9.5 eV followed by a broader peak at similar to 60 eV. Following Brawley et al. [Science 330, 789 (2010)] who have observed similarities between the total cross sections of positronium and of electrons incident upon a given target at the same velocity, a corresponding comparison is made for CO2. The comparison suggests that the former peak corresponds to the well-known (2)Pi(u) shape resonance which occurs for electrons at an incident velocity of 0.5 a.u. Further features are discussed and theoretical input is sought

Detection of low-energy charged particles by channel electron multipliers

Experimental determinations of the detection efficiency for positrons impacting a channel electron multiplier with incident energies between 0–1400 eV are presented. A log-normal dependence with energy is established and used to compute the positron-to-positronium detection efficiency ratio as a function of positronium energy, as required for determining quantities involving the ratio of positron and positronium rates. A log-normal energy-dependence is also observed in results of previous work with electrons, protons and ions

Collimated positronium production from gases

New data for positronium beam production efficiency are presented. As a converter of positrons to forward-going positronium, O2 has been found to be as good as CO2 from 250 to 400 eV. Preliminary data is also presented for the production efficiency from Ar at 2.8 eV

Centrosome misorientation reduces stem cell division during ageing

Asymmetric division of adult stem cells generates one self- renewing stem cell and one differentiating cell, thereby maintaining tissue homeostasis. A decline in stem cell function has been proposed to contribute to tissue ageing, although the underlying mechanism is poorly understood. Here we show that changes in the stem cell orientation with respect to the niche during ageing contribute to the decline in spermatogenesis in the male germ line of Drosophila. Throughout the cell cycle, centrosomes in germline stem cells ( GSCs) are oriented within their niche and this ensures asymmetric division. We found that GSCs containing misoriented centrosomes accumulate with age and that these GSCs are arrested or delayed in the cell cycle. The cell cycle arrest is transient, and GSCs appear to re- enter the cell cycle on correction of centrosome orientation. On the basis of these findings, we propose that cell cycle arrest associated with centrosome misorientation functions as a mechanism to ensure asymmetric stem cell division, and that the inability of stem cells to maintain correct orientation during ageing contributes to the decline in spermatogenesis. We also show that some of the misoriented GSCs probably originate from dedifferentiation of spermatogonia.University of Michigan ; March of Dimes Basil O'Conner Starter Scholar Research Award ; Searle Scholar Program ; NIH [P01 DK53074, R01GM072006]We thank C. Gonzalez, D. McKearin, N. Rusan, M. Peifer and the Bloomington Stock Center for fly stocks; R. Lehmann, C. Field and the Developmental Studies Hybridoma Bank for antibodies; M. Kiel and D. Nakada for help with X-ray irradiation; and S. Morrison and T. Mahowald for comments on the manuscript. This research was supported by a University of Michigan start-up fund, March of Dimes Basil O'Conner Starter Scholar Research Award and the Searle Scholar Program (to Y.M.Y.), and NIH grants P01 DK53074 (to M.T.F.) and R01GM072006 (to A.J.H.).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62879/1/nature07386.pd

Health Journalism Internships: A Social Marketing Strategy to Address Health Disparities

The USA seeks to eliminate health disparities by stimulating the rapid uptake of health-promoting behaviors within disadvantaged communities. A health journalism internship incorporates social marketing strategies to increase communities' access to cancer information, while helping the interns who are recruited from underrepresented communities gain admission to top graduate schools. Interns are taught basic health journalism skills that enable them to create immediate streams of cancer-related press releases for submission to community newspapers. Interns are charged with the social responsibility of continuing this dissemination process throughout their careers. Intermediate outcomes are measured as mediators of distal behavioral change goals

Asymmetric and symmetric stem-cell divisions in development and cancer

Much has been made of the idea that asymmetric cell division is a defining characteristic of stem cells that enables them to simultaneously perpetuate themselves (self-renew) and generate differentiated progeny. Yet many stem cells can divide symmetrically, particularly when they are expanding in number during development or after injury. Thus, asymmetric division is not necessary for stem-cell identity but rather is a tool that stem cells can use to maintain appropriate numbers of progeny. The facultative use of symmetric or asymmetric divisions by stem cells may be a key adaptation that is crucial for adult regenerative capacity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62868/1/nature04956.pd