Propriedades psicométricas da Dutch Fatigue Scale e Dutch Exertion Fatigue Scale: versão brasileira Propiedades psicométricas de la Dutch Fatigue Scale y Dutch Exertion Fatigue Scale: versión Brasileña Psychometric properties of the Dutch Fatigue Scale and the Dutch Exertion Fatigue Scale: Brazilian version

Fadiga é uma resposta humana em diversas situações agudas e crônicas e também na população geral. Este artigo relata estudo realizado para estimar confiabilidade e validade da Dutch Fatigue Scale (DUFS) e da Dutch Exertion Fatigue Scale (DEFS) adaptadas para o Brasil. Trezentos pacientes ambulatoriais com insuficiência cardíaca e 64 voluntários responderam a DUFS e a DEFS vertidas para o português. Análise fatorial sobre o conjunto de itens das duas escalas produziu solução com um fator para cada escala (variância explicada = 53,9%) e boas estimativas de confiabilidade pelo alfa de Chronbach (DUFS=0,85 e DEFS=0,92) foram obtidas. Na amostra de pacientes, os escores nas escalas foram positivamente associados com a classe funcional da insuficiência cardíaca (DUFS e DEFS p=0,000), com os escores de depressão (DUFS r s=0,63; p=0,00 e DEFS r s=0,55; p=0,00) e com distúrbio de sono (DUFS e DEFS p=0,000). As versões brasileiras mostraram propriedades semelhantes as das escalas originais.<br>Fatiga es una respuesta humana en muchas situaciones agudas e crónicas e también en la populación general. Este artículo relata estudio realizado para estimar la confiabilidad e validad de la Dutch Fatigue Scale (DUFS) y de la Dutch Exertion Fatigue Scale (DEFS) adaptadas para o Brasil. Trescientos pacientes con insuficiencia cardiaca y 64 voluntarios respondieran a la DUFS y DEFS vertidas para lo portugués. El análisis factorial de los ítems ha producido solución con un factor para cada escala (variancia explicada = 53,9%) y buenas estimativas de confiabilidad por lo alfa de Chronbach (DUFS=0,85 e DEFS=0,92) fueron obtenidas. En la muestra de pacientes, las puntuaciones en las escalas fueron positivamente asociadas con la clase funcional de la insuficiencia cardiaca (DUFS y DEFS p=0,000), los escores de depresión (DUFS r s=0,63; p=0,00 y DEFS r s=0,55; p=0,00), y con las alteraciones del sueno (DUFS y DEFS p=0,000). Las versiones brasileras mostraran propiedades similares a las das escalas originais.<br>Fatigue is a human response in varied acute and chronic conditions and also in general population. This article reports a study conducted to estimate reliability and validity of the Dutch Fatigue Scale (DUFS) and the Dutch Exertion Fatigue Scale (DEFS) adapted for Brazilian use. Three-hundred heart failure patients and 64 healthier volunteers answered the DUFS and DEFS translated into Portuguese. Factorial analysis of DUFS and DEFS items yield a solution with one factor for each scale (explained variance = 53.9%), and good reliability estimates were obtained by the Chronbach's alpha (DUFS=.85 e DEFS=.92). In the patient sample, scales scores were positively associated with heart failure functional class (DUFS and DEFS p=.00), depression scores (DUFS r s=.63; p=.00 and DEFS r s=.55; p=.00), and sleep disturbance (DUFS and DEFS p=.00). Brazilian versions of DUFS and DEFS presented psychometric properties similar to those of the original ones

Effects of digoxin on muscle reflexes in normal humans.

Blockade of the skeletal muscle Na(+)-K(+)-ATPase pump by digoxin could result in a more marked hyperkaliema during a forearm exercise, which in turn could stimulate the mechano- and metaboreceptors. In a randomized, double-blinded, placebo-controlled, and cross-over-design study, we measured mean blood pressure (MBP), heart rate (HR), ventilation (V(E)), oxygen saturation (SpO(2)), muscle sympathetic nerve activity (MSNA), venous plasma potassium and lactic acid during dynamic handgrip exercises, and local circulatory arrest in 11 healthy subjects. Digoxin enhanced MBP during exercise but not during the post-handgrip ischemia and had no effect on HR, V(E), SpO(2), and MSNA. Venous plasma potassium and lactic acid were also not affected by digoxin-induced skeletal muscle Na(+)-K(+)-ATPase blockade. We conclude that digoxin increased MBP during dynamic exercise in healthy humans, independently of changes in potassium and lactic acid. A modest direct sensitization of the muscle mechanoreceptors is unlikely and other mechanisms, independent of muscle reflexes and related to the inotropic effects of digoxin, might be implicated.Journal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe