Vicarious nucleophilic substitution of hydrogen vs. ANRORC-type ring transformation in reactions of 1,2,4-triazines with alpha-halocarbanions. Novel route to functionalized pyrazoles

A novel route to pyrazole derivatives bearing sulfonyl, aminosulfonyl, alkoxy- and aryloxysulfonyl groups at C-3 by ring transformation of 3-chloro-6-aryl-1,2,4-triazines 1a-c with alpha-halocarbanions 2a-h is described

Synthesis of Unsymmetrical Annulated 2,2’-Bipyridine Analogues with Attached Cycloalkene and Piperidine Rings via Sequential Diels-Alder Reaction of 5,5’-bi-1,2,4-triazines

Synthesis of bisfunctionalized unsymmetrical 2,2’-bipyridines 8 or their sulfonyl derivatives 12a,b are described. They were prepared via the Diels-Alder reaction of 1-methyl-4-pyrrolidin-1-yl-1,2,3,6-tetrahydropyridine (6) with 3,3’-bis(methyl- sulfanyl)-5,5’-bi-1,2,4-triazine (1). The reaction leads to the single cycloaddition product 7 which undergoes Diels-Alder reaction with cyclic enamines 2a,b to give unsymmetrical 2,2’-bipyridine derivatives 8, consisting of the two different heterocyclic units: cycloalkeno[c]pyridine and 2,6-naphthyridine

Biological activity and synthesis of sulfonamide derivatives: a brief review

Sulfonamidy (SO2-NH-) są lekami powszechnie stosowanymi ze względu na ich trwałość i tolerancję przez organizm człowieka. Stanowią dobrą grupę zabezpieczającą amin czyniąc je związkami aktywnymi biologicznie. Aktywność ta jest wynikiem obecności różnych grup funkcyjnych. Szerokie zastosowanie sulfonamidów stało się przyczyną poszukiwania nowych metod ich syntezy. Artykuł przedstawia krótki przegląd literaturowy najbardziej popularnych i nowoczesnych metod syntezy pochodnych sulfonamidowych.Sulfonamides (SO2-NH-) have been the center of the drug structures as they are quite stable and well tolerated in human beings. The sulfonamides are very important protected intermediates of amines with several types of biological activities. Activity of the sulfonamides is due to different functional groups present in them. Due to the broad applicability of sulfonamides, it is desirable to find general and effective methods for their synthesis. Different methods have been adopted to synthesize sulfonamides. Here is a short review which provides several of the most common and recent methods of sulfonamide synthesis

Synthesis of 4-functionalized terdendate pyridine-based ligands

Four different 4-functionalised pyridine-based ligands were synthesized with aminomethyl, oxazolinyl, pyrazolyl and methylimidazolyl groups at the 2- and 6-position. The nitrogens of these groups together with the pyridine nitrogen can act as terdendate ligands for metal ions. Synthetic handles on the 4-position of the pyridine :group were introduced via ether or ester bonds leading to monofunctional, bifunctional and amphiphilic ligands. (C) 2003 Published by Fisevier Science Ltd