Some problems of dialect lexicography with particular reference to the preparation of a draft of an illustrative, experientially categorised Dictionary of South African English

This dissertation consists in essence of an experiment and a commentary upon it. The text which constitutes Part II is a lexicographical experiment incorporating some features and treatments not usual in lexicography, and Part I consists of a discussion of the problems encountered, principles applied and procedures followed. Neither the matter nor the manner of the experiment, however, lends itself in the present state of our knowledge to the fully impersonal objectivity that is often claimed for the experiments in the physical sciences. At the same time every effort has been made to establish an unbiased record of the data and to maintain a certain methodological consistency. The main experimental feature of Part II is that it is an attempt to combine an orthodox, alphabetical dictionary with an experiential categorisation of the vocabulary, without repeating the entire data for each type of treatment. This has been done by means of a series of numbered, classified word-lists with a limited subject index as a guide to their use. The entries themselves, instead of being repeated in the order of their classification, are numbered according to the category or categories to which the word defined belongs. It can then, by means of its number(s), be found in its own lexical or experiential set (or sets) in the categorised section. This part of the work might be better described as lexicology rather than lexicography but does, I think, prove itself to be a useful adjunct to the A - Z lexicon proper. Apart from the detailed categorisation system the text contains three features not normally included in dictionaries of small compass: illustrative quotations, etymologies and a number of tentative parallels between South African and other varieties of English by means of cross-references to items of similar or related meaning or form in the English of Australia, Canada, the U.S.A., Hong Kong, Anglo-India and other 'overseas' English speech communities. Introduction, p. 1

The soldier and South African English

No abstrac

Wind-direction effects on urban-type flows

Practically all extant work on flows over obstacle arrays, whether laboratory experiments or numerical modelling, is for cases where the oncoming wind is normal to salient faces of the obstacles. In the field, however, this is rarely the case. Here, simulations of flows at various directions over arrays of cubes representing typical urban canopy regions are presented and discussed. The computations are of both direct numerical simulation and large-eddy simulation type. Attention is concentrated on the differences in the mean flow within the canopy region arising from the different wind directions and the consequent effects on global properties such as the total surface drag, which can change very significantly—by up to a factor of three in some circumstances. It is shown that for a given Reynolds number the typical viscous forces are generally a rather larger fraction of the pressure forces (principally the drag) for non-normal than for normal wind directions and that, dependent on the surface morphology, the average flow direction deep within the canopy can be largely independent of the oncoming wind direction. Even for regular arrays of regular obstacles, a wind direction not normal to the obstacle faces can in general generate a lateral lift force (in the direction normal to the oncoming flow). The results demonstrate this and it is shown how computations in a finite domain with the oncoming flow generated by an appropriate forcing term (e.g. a pressure gradient) then lead inevitably to an oncoming wind direction aloft that is not aligned with the forcing term vector

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia

From the laboratory perspective, effective management of patients with chronic myeloid leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential assessment of levels of residual disease and investigation of possible reasons for resistance, relapse or progression. Our scientific and clinical knowledge underpinning these requirements continues to evolve, as do laboratory methods and technologies. The European LeukemiaNet convened an expert panel to critically consider the current status of genetic laboratory approaches to help diagnose and manage CML patients. Our recommendations focus on current best practice and highlight the strengths and pitfalls of commonly used laboratory tests

Comprehensive Characterization of a Novel Intronic Pseudo-Exon Inserted within an e14/a2 BCR-ABL Rearrangement in a Patient with Chronic Myeloid Leukemia

We identified a novel breakpoint cluster region-ABL rearrangement in a chronic myeloid leukemia (CML) patient. The e14/a2 (b3/a2) type BCR-ABL mRNA incorporated a 42-nucleotide intronic insertion of ABL intron Ib between BCR exon e14 and ABL exon a2. As we hypothesized that the rearrangement between BCR and ABL genes occurred near the inserted sequence and because of the relative small size of BCR intron 14, we determined the BCR-ABL breakpoint at the genomic DNA level. Using a PCR-based method, this analysis revealed that i) BCR intron 14 brought a potential lariat branch point and the polypyrimidine tract, ii) the BCR-ABL breakpoint created a chimeric acceptor site, and iii) the inserted sequence of ABL intron Ib carried at its 3′ end a well-conserved donor splice site. Therefore, the inserted sequence was flanked by canonical consensus splice sites and recognized as a pseudo-exon (as shown by splice site prediction and exon finder software). Moreover, the insertion did not disrupt the reading frame between BCR and ABL and did not produce a premature stop codon. Instead, this novel BCR-ABL chimeric transcript encoded a functional oncoprotein with an in-frame insertion of 15 new amino acids