3,379 research outputs found
PDB20 BIPHASIC INSULIN ASPART 30 VERSUS ORAL HYPOGLYCEMIC AGENTS IN THE TREATMENT OF TYPE-2 DIABETES: LONG-TERM PROJECTION OF CLINICAL AND COST OUTCOMES IN SWEDEN
Simulating the WFIRST coronagraph Integral Field Spectrograph
A primary goal of direct imaging techniques is to spectrally characterize the
atmospheres of planets around other stars at extremely high contrast levels. To
achieve this goal, coronagraphic instruments have favored integral field
spectrographs (IFS) as the science cameras to disperse the entire search area
at once and obtain spectra at each location, since the planet position is not
known a priori. These spectrographs are useful against confusion from speckles
and background objects, and can also help in the speckle subtraction and
wavefront control stages of the coronagraphic observation. We present a
software package, the Coronagraph and Rapid Imaging Spectrograph in Python
(crispy) to simulate the IFS of the WFIRST Coronagraph Instrument (CGI). The
software propagates input science cubes using spatially and spectrally resolved
coronagraphic focal plane cubes, transforms them into IFS detector maps and
ultimately reconstructs the spatio-spectral input scene as a 3D datacube.
Simulated IFS cubes can be used to test data extraction techniques, refine
sensitivity analyses and carry out design trade studies of the flight CGI-IFS
instrument. crispy is a publicly available Python package and can be adapted to
other IFS designs.Comment: 15 page
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Giving stakeholders a voice in governance: Biodiversity priorities for New Zealand's agriculture
Abstract: Mainstreaming biodiversity across government and society is recognised by international policy as critical to achieving positive conservation outcomes. With âparticipatory governanceâ increasingly being applied to achieve collective action in conservation, there are growing calls to critically review such processes to capture their complexity and manage for emergent outcomes. This paper critically reviews a case study, aiming to give a broad range of stakeholders a voice in setting biodiversity priorities for New Zealand's agricultural landscape, in relation to four principles for knowledge coâproduction in sustainability: contextâbased, pluralistic, goalâorientated and interactive. Aiming to facilitate an inclusive but rapid participation process, while not overburdening those willing to participate, three pathways for engagement were offered. Stakeholder participants were recruited from public, private and civic sectors involved in managing New Zealand's farmland biodiversity. An initial scoping exercise helped elevate biodiversity groups and management actions distinct to New Zealand's social and environmental context. Online surveys then gave stakeholders, from a diverse range of roles and sectors, a nationwide voice to express their own biodiversity interests and needs; these were reviewed by an advisor panel to reach consensus on final priorities that reflected the biodiversity outcomes that matter most to stakeholders involved in managing New Zealand's agricultural landscape and the management practices they considered most relevant to achieving those outcomes. This knowledge coâproduction process delivered multiple gains that would not have been achieved had a more traditional scienceâbased process been applied, such as wide stakeholder engagement, identification of a tangible starting point, mitigation of bias or conflict risks, enhanced researcher and practitioner capabilities and a shared understanding of the opportunities and challenges for future development. Institutes addressing conservation challenges within local contexts need to: be âboundaryâspanningâ to manage crossâscale influences and enable desired conservation behaviours; plan explicitly for the substantial effort required to overcome existing power hierarchies and facilitate transparent and structured decision processes that deliver social justice; better capture the relational values of nature to more successfully leverage peoplesâ connection to nature in conservation policies and practices; and incorporate wider environmental (e.g. biosecurity), social, economic and political considerations. A free Plain Language Summary can be found within the Supporting Information of this article
Sinusoidal obstruction syndrome (veno-occlusive disease) in a patient receiving bevacizumab for metastatic colorectal cancer: a case report
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2). Our study has defined the origin of these macrophages by showing Gr1+ inflammatory monocytes (IMs) are preferentially recruited to pulmonary metastases but not primary mammary tumors, a process also found for human IMs in pulmonary metastases of human breast cancer cells. The recruitment of these CCR2 (receptor for chemokine CCL2) expressing IMs and subsequently MAMs and their interaction with metastasizing tumor cells is dependent on tumor and stromal synthesized CCL2 (FigS1). Inhibition of CCL2/CCR2 signaling using anti-CCL2 antibodies blocks IM recruitment and inhibits metastasis in vivo and prolongs the survival of tumor-bearing mice. Depletion of tumor cell-derived CCL2 also inhibits metastatic seeding. IMs promote tumor cell extravasation in a process that requires monocyte-derived VEGF. CCL2 expression and macrophage infiltration are correlated with poor prognosis and metastatic disease in human breast cancer (Fig S2)(3-6). Our data provides the mechanistic link between these two clinical associations and indicates new therapeutic targets for treating metastatic breast disease
The APOSTEL recommendations for reporting quantitative optical coherence tomography studies
OBJECTIVE: To develop consensus recommendations for reporting of quantitative optical coherence tomography (OCT) study results.
METHODS: A panel of experienced OCT researchers (including 11 neurologists, 2 ophthalmologists, and 2 neuroscientists) discussed requirements for performing and reporting quantitative analyses of retinal morphology and developed a list of initial recommendations based on experience and previous studies. The list of recommendations was subsequently revised during several meetings of the coordinating group.
RESULTS: We provide a 9-point checklist encompassing aspects deemed relevant when reporting quantitative OCT studies. The areas covered are study protocol, acquisition device, acquisition settings, scanning protocol, funduscopic imaging, postacquisition data selection, postacquisition data analysis, recommended nomenclature, and statistical analysis.
CONCLUSIONS: The Advised Protocol for OCT Study Terminology and Elements recommendations include core items to standardize and improve quality of reporting in quantitative OCT studies. The recommendations will make reporting of quantitative OCT studies more consistent and in line with existing standards for reporting research in other biomedical areas. The recommendations originated from expert consensus and thus represent Class IV evidence. They will need to be regularly adjusted according to new insights and practices
The impact of childhood glaucoma on psychosocial functioning and quality of life: a review of the literature
We present a novel comprehensive literature review of studies of the psychosocial functioning (PF) and quality of life (QoL) of patients with childhood glaucoma and their caregivers. Our findings demonstrate variable study quality and approach, as well as inconsistent results relating to the association of glaucoma-specific factors and sociodemographic variables with measured PF and QoL. Future studies should focus on the development of culturally cognizant and standardized assessment tools, execution of multi-center longitudinal studies with global representation, evaluation of PF and QoL among siblings and childhood glaucoma providers, and implementation of interventions to improve patient and caregiver PF and QoL
Angiography suite concept for an interdisciplinary centre for cardiovascular interventions
A permanently mounted angiography suite in an operating room (OR) is considered to be a hybrid OR. However, regular use for angiographic interventions is restricted with this setup. We introduce an alternative use of space for the efficient utilisation of an angiographic suite outside the surgical unit. This concept includes three scenarios that describe a modification of the catheter suite according to the specific clinical demands by adapting the workflow
Dust-free quasars in the early Universe
The most distant quasars known, at redshifts z=6, generally have properties
indistinguishable from those of lower-redshift quasars in the rest-frame
ultraviolet/optical and X-ray bands. This puzzling result suggests that these
distant quasars are evolved objects even though the Universe was only seven per
cent of its current age at these redshifts. Recently one z=6 quasar was shown
not to have any detectable emission from hot dust, but it was unclear whether
that indicated different hot-dust properties at high redshift or if it is
simply an outlier. Here we report the discovery of a second quasar without
hot-dust emission in a sample of 21 z=6 quasars. Such apparently hot-dust-free
quasars have no counterparts at low redshift. Moreover, we demonstrate that the
hot-dust abundance in the 21 quasars builds up in tandem with the growth of the
central black hole, whereas at low redshift it is almost independent of the
black hole mass. Thus z=6 quasars are indeed at an early evolutionary stage,
with rapid mass accretion and dust formation. The two hot-dust-free quasars are
likely to be first-generation quasars born in dust-free environments and are
too young to have formed a detectable amount of hot dust around them.Comment: To be published in Nature on the 18 March 2010
Ages for exoplanet host stars
Age is an important characteristic of a planetary system, but also one that
is difficult to determine. Assuming that the host star and the planets are
formed at the same time, the challenge is to determine the stellar age.
Asteroseismology provides precise age determination, but in many cases the
required detailed pulsation observations are not available. Here we concentrate
on other techniques, which may have broader applicability but also serious
limitations. Further development of this area requires improvements in our
understanding of the evolution of stars and their age-dependent
characteristics, combined with observations that allow reliable calibration of
the various techniques.Comment: To appear in "Handbook of Exoplanets", eds. Deeg, H.J. & Belmonte,
J.A, Springer (2018
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