Análises do sêmen de suínos em centrais de inseminação artificial e detecção de circovírus suíno tipo 2 (PCV2).

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International Consensus on Differential Diagnosis and Management of Patients With Danon Disease: JACC State-of-the-Art Review

Danon disease is a rare X-linked autophagic vacuolar cardioskeletal myopathy associated with severe heart failure that can be accompanied with extracardiac neurologic, skeletal, and ophthalmologic manifestations. It is caused by loss of function variants in the LAMP2 gene and is among the most severe and penetrant of the genetic cardiomyopathies. Most patients with Danon disease will experience symptomatic heart failure. Male individuals generally present earlier than women and die of either heart failure or arrhythmia or receive a heart transplant by the third decade of life. Herein, the authors review the differential diagnosis of Danon disease, diagnostic criteria, natural history, management recommendations, and recent advances in treatment of this increasingly recognized and extremely morbid cardiomyopathy

Frequency of left ventricular hypertrophy in non-valvular atrial fibrillation

Left ventricular hypertrophy (LVH) is significantly related to adverse clinical outcomes in patients at high risk of cardiovascular events. In patients with atrial fibrillation (AF), data on LVH, that is, prevalence and determinants, are inconsistent mainly because of different definitions and heterogeneity of study populations. We determined echocardiographic-based LVH prevalence and clinical factors independently associated with its development in a prospective cohort of patients with non-valvular (NV) AF. From the "Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study" (ARAPACIS) population, 1,184 patients with NVAF (mean age 72 \ub1 11 years; 56% men) with complete data to define LVH were selected. ARAPACIS is a multicenter, observational, prospective, longitudinal on-going study designed to estimate prevalence of peripheral artery disease in patients with NVAF. We found a high prevalence of LVH (52%) in patients with NVAF. Compared to those without LVH, patients with AF with LVH were older and had a higher prevalence of hypertension, diabetes, and previous myocardial infarction (MI). A higher prevalence of ankle-brachial index 640.90 was seen in patients with LVH (22 vs 17%, p = 0.0392). Patients with LVH were at significantly higher thromboembolic risk, with CHA2DS2-VASc 652 seen in 93% of LVH and in 73% of patients without LVH (p <0.05). Women with LVH had a higher prevalence of concentric hypertrophy than men (46% vs 29%, p = 0.0003). Logistic regression analysis demonstrated that female gender (odds ratio [OR] 2.80, p <0.0001), age (OR 1.03 per year, p <0.001), hypertension (OR 2.30, p <0.001), diabetes (OR 1.62, p = 0.004), and previous MI (OR 1.96, p = 0.001) were independently associated with LVH. In conclusion, patients with NVAF have a high prevalence of LVH, which is related to female gender, older age, hypertension, and previous MI. These patients are at high thromboembolic risk and deserve a holistic approach to cardiovascular prevention

Current Therapeutic Options for Heart Failure in Elderly Patients

Heart failure (HF) is a major and growing public health problem with high morbidity and mortality (Ponikowski et al., 2016). It affects 1-2% of the general population in developed countries, and the average age at diagnosis is 76 years. Because of a better management of acute phase and comorbidities, HF incidence is increasing in elderly patients, with a prevalence rising to 10% among people aged 65 years or older (Mozaffarian et al., 2014). Therefore, a substantial number of elderly patients need to be treated. However, because of clinical trial exclusion criteria or coexisting comorbidities, currently recommended therapies are widely based on younger population with a much lower mean age. In this review, we will focus on available pharmacological, electrical, and mechanical therapies, underlining pros, cons, and practical considerations of their use in this specific patient population

Initial Geometric Imperfections: A Robust, Closed-Section Cold-Formed Box Profile Application Subject to Local Buckling

Initial geometric imperfections are important for simulating local buckling in numerical models. References are found in the technical literature regarding open-section cold formed profiles. This work presents new procedures applied to a robust and closed-section cold formed profile subject to local buckling, and the use of procedures described in the technical literature already successfully used for open section profiles. The difference of this work in relation to the research already carried out is in the type of profile studied, in the mode of failure of the same and in the form of determination of the initial imperfections. The object of study of this work is a closed-section cold formed box profile with a short length when compared with its cross section and with local buckling failure mode. The strategies used in the present work to consider the initial geometric imperfections were to perform the linear stability analysis using the finite element method to obtain the local buckling mode that represents the deformed box profile geometry, to apply a multiplication factor in the displacements, replace the new geometry node coordinates for all profile nodes to induce the local buckling deformation mode, with model validation through experimental testing and the Effective Width Method (MLE) (ABNT NBR 14762 [1]). Finally, using the results of the collapse load of the experimental trial as a basis, it was possible to compare the results obtained by MLE and MEF. Thus, the presentation of this work used a methodology that describes the local buckling behavior and verified the precepts of the existing norms on the subject, combining theoretical and experimental methods, as they bring a better understanding of the structural problem in question

Initial geometric imperfections: a robust, closed-section cold-formed box profile application subject to local buckling

Initial geometric imperfections are important for simulating local buckling in numerical models. References are found in the technical literature regarding open-section cold formed profiles. This work presents new procedures applied to a robust and closed-section cold formed profile subject to local buckling, and the use of procedures described in the technical literature already successfully used for open section profiles. The difference of this work in relation to the research already carried out is in the type of profile studied, in the mode of failure of the same and in the form of determination of the initial imperfections. The object of study of this work is a closed-section cold formed box profile with a short length when compared with its cross section and with local buckling failure mode. The strategies used in the present work to consider the initial geometric imperfections were to perform the linear stability analysis using the finite element method to obtain the local buckling mode that represents the deformed box profile geometry, to apply a multiplication factor in the displacements, replace the new geometry node coordinates for all profile nodes to induce the local buckling deformation mode, with model validation through experimental testing and the Effective Width Method (MLE) (ABNT NBR 14762 [1]). Finally, using the results of the collapse load of the experimental trial as a basis, it was possible to compare the results obtained by MLE and MEF. Thus, the presentation of this work used a methodology that describes the local buckling behavior and verified the precepts of the existing norms on the subject, combining theoretical and experimental methods, as they bring a better understanding of the structural problem in question