Evidence for Intergalactic Absorption in the TeV Gamma-Ray Spectrum of Mkn 501

The recent HEGRA observations of the blazar Mkn 501 show strong curvature in the very high energy gamma-ray spectrum. Applying the gamma-ray opacity derived from an empirically based model of the intergalactic infrared background radiation field (IIRF), to these observations, we find that the intrinsic spectrum of this source is consistent with a power-law: dN/dE~ E^-alpha with alpha=2.00 +/- 0.03 over the range 500 GeV - 20 TeV. Within current synchrotron self-Compton scenarios, the fact that the TeV spectral energy distribution of Mkn 501 does not vary with luminosity, combined with the correlated, spectrally variable emission in X-rays, as observed by the BeppoSAX and RXTE instruments, also independently implies that the intrinsic spectrum must be close to alpha=2. Thus, the observed curvature in the spectrum is most easily understood as resulting from intergalactic absorption.Comment: 7 pages, 1 figure, accepted in ApJ Letters 1999 April

On the distribution of career longevity and the evolution of home run prowess in professional baseball

Statistical analysis is a major aspect of baseball, from player averages to historical benchmarks and records. Much of baseball fanfare is based around players exceeding the norm, some in a single game and others over a long career. Career statistics serve as a metric for classifying players and establishing their historical legacy. However, the concept of records and benchmarks assumes that the level of competition in baseball is stationary in time. Here we show that power-law probability density functions, a hallmark of many complex systems that are driven by competition, govern career longevity in baseball. We also find similar power laws in the density functions of all major performance metrics for pitchers and batters. The use of performance-enhancing drugs has a dark history, emerging as a problem for both amateur and professional sports. We find statistical evidence consistent with performance-enhancing drugs in the analysis of home runs hit by players in the last 25 years. This is corroborated by the findings of the Mitchell Report [1], a two-year investigation into the use of illegal steroids in major league baseball, which recently revealed that over 5 percent of major league baseball players tested positive for performance-enhancing drugs in an anonymous 2003 survey.Comment: 5 pages, 5 figures, 2-column revtex4 format. Revision has change of title, a figure added, and minor changes in response to referee comment

VSOP and Ground-based VLBI Imaging of the TeV Blazar Markarian 421 at Multiple Epochs

We present thirty VLBI images of the TeV blazar Markarian 421 (1101+384) at fifteen epochs spanning the time range from 1994 to 1997, and at six different frequencies from 2.3 to 43 GHz. The imaged observations include a high-resolution 5 GHz VLBI Space Observatory Programme (VSOP) observation with the HALCA satellite on 1997 November 14; full-track VLBA observations from 1994 April, 1996 November, and 1997 May at frequencies between 5 and 43 GHz; six epochs of VLBA snapshot observations at frequencies between 2 and 15 GHz from Radio Reference Frame studies; and five geodetic VLBI observations at 2 and 8 GHz from the archive of the Washington VLBI Correlator Facility located at the U.S. Naval Observatory. The dense time coverage of the images allows us to unambiguously track components in the parsec-scale jet over the observed time range. We measure the speeds of three inner jet components located between 0.5 and 5 mas from the core (0.3 to 3 pc projected linear distance) to be 0.19 +/- 0.27, 0.30 +/- 0.07, and -0.07 +/- 0.07 c (H_{0}=65 km s^{-1} Mpc^{-1}). If the sole 43 GHz image is excluded, all measured speeds are consistent with no motion. These speeds differ from tentative superluminal speeds measured by Zhang & B\aa\aa th from three epochs of data from the early 1980's. Possible interpretations of these subluminal speeds in terms of the high Doppler factor demanded by the TeV variability of this source are discussed.Comment: 18 pages, including 7 figures, emulateapj.sty, accepted by The Astrophysical Journal; modified text describing Radio Reference Frame observation

Parsec Scale Properties of Markarian 501

We present the results of a high angular resolution study of the BL Lac object Markarian 501 in the radio band. We consider data taken at 14 different epochs, ranging between 1.6 GHz and 22 GHz in frequency, and including new Space VLBI observations obtained on 2001 March 5 and 6 at 1.6 and 5 GHz. We study the kinematics of the parsec-scale jet and estimate its bulk velocity and orientation with respect to the line of sight. Limb brightened structure in the jet is clearly visible in our data and we discuss its possible origin in terms of velocity gradients in the jet. Quasi-simultaneous multi-wavelength observations allow us to map the spectral index distribution and to compare it to the jet morphology. Finally, we estimate the physical parameters of the parsec-scale jet.Comment: accepted for publication in ApJ; 24 pages with 17 figures (fig. 1 and fig. 2 available only as .jpg files

Multiwavelength Observations of a Flare from Markarian 501

We present multiwavelength observations of the BL Lacertae object Markarian 501 (Mrk 501) in 1997 between April 8 and April 19. Evidence of correlated variability is seen in very high energy (VHE, E > 350 GeV) gamma-ray observations taken with the Whipple Observatory gamma-ray telescope, data from the Oriented Scintillation Spectrometer Experiment of the Compton Gamma-Ray Observatory, and quicklook results from the All-Sky Monitor of the Rossi X-ray Timing Explorer while the Energetic Gamma-Ray Experiment Telescope did not detect Mrk 501. Short term optical correlations are not conclusive but the U-band flux observed with the 1.2m telescope of the Whipple Observatory was 10% higher than in March. The average energy output of Mrk 501 appears to peak in the 2 keV to 100 keV range suggesting an extension of the synchrotron emission to at least 100 keV, the highest observed in a blazar and ~100 times higher than that seen in the other TeV-emitting BL Lac object, Mrk 421. The VHE gamma-ray flux observed during this period is the highest ever detected from this object. The VHE gamma-ray energy output is somewhat lower than the 2-100 keV range but the variability amplitude is larger. The correlations seen here do not require relativistic beaming of the emission unless the VHE spectrum extends to >5 TeV.Comment: 10 pages, 2 figures, accepted for publication in ApJ Letter

Multiwavelength observations of Mkn 501 during the 1997 high state

During the observation period 1997, the nearby Blazar Mkn 501 showed extremely strong emission and high variability. We examine multiwavelength aspects of this event using radio, optical, soft and hard X-ray and TeV data. We concentrate on the medium-timescale variability of the broadband spectra, averaged over weekly intervals. We confirm the previously found correlation between soft and hard X-ray emission and the emission at TeV energies, while the source shows only minor variability at radio and optical wavelengths. The non-linear correlation between hard X-ray and TeV fluxes is consistent with a simple analytic estimate based on an SSC model in which Klein-Nishina effects are important for the highest-energy electrons in the jet, and flux variations are caused by variations of the electron density and/or the spectral index of the electron injection spectrum. The time-averaged spectra are fitted with a Synchrotron Self-Compton (SSC) dominated leptonic jet model, using the full Klein-Nishina cross section and following the self-consistent evolution of relativistic particles along the jet, accounting for gamma-gamma absorption and pair production within the source as well as due to the intergalactic infrared background radiation. The contribution from external inverse-Compton scattering is tightly constrained by the low maximum EGRET flux and found to be negligible at TeV energies. We find that high levels of the X-ray and TeV fluxes can be explained by a hardening of the energy spectra of electrons injected at the base of the jet, in remarkable contrast to the trend found for gamma-ray flares of the flat-spectrum radio quasar PKS 0528+134.Comment: accepted for publication in ApJ, 31 pages, 11 figure

Peripheral arterial disease (PAD) – A challenging manifestation of atherosclerosis

The diagnosis of peripheral arterial disease (PAD) is not always evident as symptoms and signs may show great variation. As all grades of PAD are linked to both an increased risk for cardiovascular complications and adverse limb events, awareness of the condition and knowledge about diagnostic measures, prevention and treatment is crucial. This article presents in a condensed form information on PAD and its management

Sodium Transport in Capillaries Isolated from Rat Brain

Brain capillary endothelial cells form a bloodbrain barrier (BBB) that appears to play a role in fluid and ion homeostasis in brain. One important transport system that may be involved in this regulatory function is the Na + ,K + -ATPase that was previously demonstrated to be present in isolated brain capillaries. The goal of the present study was to identify additional Na + transport systems in brain capillaries that might contribute to BBB function. Microvessels were isolated from rat brains and 22 Na + uptake by and efflux from the cells were studied. Total 22 Na + uptake was increased and the rate of 22 Na + efflux was decreased by ouabain, confirming the presence of Na + ,K + -ATPase in capillary cells. After inhibition of Na + ,K + -ATPase activity, another saturable Na + transport mechanism became apparent. Capillary uptake of 22 Na + was stimulated by an elevated concentration of Na + or H + inside the cells and inhibited by extracellular Na + , H + , Li + , and NH 4 + . Amiloride inhibited 22 Na + uptake with a K i between 10 −5 and 10 −6 M but there was no effect of 1 mM furosemide on 22 Na + uptake by the isolated microvessels. These results indicate the presence in brain capillaries of a transport system capable of mediating Na + / Na + and Na + /H + exchange. As a similar transport system does not appear to be present on the luminal membrane of the brain capillary endothelial cell, it is proposed that Na + /H + exchange occurs primarily across the antiluminal membrane.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66187/1/j.1471-4159.1983.tb09065.x.pd