DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries-5

<p><b>Copyright information:</b></p><p>Taken from "DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries"</p><p>BMC Molecular Biology 2006;7():12-12.</p><p>Published online 16 Mar 2006</p><p>PMCID:PMC1434758.</p><p></p>rnate base mutant data points along with the wild type data point for the CDEI position 5. This position possesses unusually good correlations for both unsignedPD (A) and signedPD (B) plots

DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries-2

<p><b>Copyright information:</b></p><p>Taken from "DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries"</p><p>BMC Molecular Biology 2006;7():12-12.</p><p>Published online 16 Mar 2006</p><p>PMCID:PMC1434758.</p><p></p>B) signedPD. Correlation values, R, are shown within text boxes. The position of the wild type data point is plotted as a 'W'. Dashed lines show 95% confidence intervals for average predicted values

DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries-3

<p><b>Copyright information:</b></p><p>Taken from "DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries"</p><p>BMC Molecular Biology 2006;7():12-12.</p><p>Published online 16 Mar 2006</p><p>PMCID:PMC1434758.</p><p></p> is marked by a triangle along the x-axis. Shaded dual tail areas correspond to probabilities of better correlations than the actual value reported in Table 1. The normal curve, superimposed on each of the histograms using the mean and standard deviation of the distribution, reveals the normal character of the CDEI distributions (A) & (C) and contrasts with the bimodal CDEIII distributions (B) & (D)

DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries-1

<p><b>Copyright information:</b></p><p>Taken from "DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries"</p><p>BMC Molecular Biology 2006;7():12-12.</p><p>Published online 16 Mar 2006</p><p>PMCID:PMC1434758.</p><p></p> in both core binding areas are shown as squares with the mutant base placed above the corresponding base in the wild type sequence

DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries-0

<p><b>Copyright information:</b></p><p>Taken from "DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries"</p><p>BMC Molecular Biology 2006;7():12-12.</p><p>Published online 16 Mar 2006</p><p>PMCID:PMC1434758.</p><p></p> asterisks. The flanking palindrome areas of CDEIII are indicated by lighter arrows. Below each of the wild type sequences, the different mutant bases tested for each wild type base position are shown. Beneath each mutant, the bold vertical line indicates it's relative log(loss) rate, of magnitude indicated by the log scale shown. These data are recreated from Hegemann et al [7] Figure 3. The inset depicts a model of the yeast centromere showing the modified nucleosome formed by wrapping the CDEI site into close proximity to CDEIII. Also shown are their associated protein complexes that along with additional binding proteins form the kinetochore, which bind the spindle microtubule [2]

DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries-4

<p><b>Copyright information:</b></p><p>Taken from "DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries"</p><p>BMC Molecular Biology 2006;7():12-12.</p><p>Published online 16 Mar 2006</p><p>PMCID:PMC1434758.</p><p></p>). The actual values obtained from the true PD-scale are indicated by arrows and marked by '+' signs. The probabilities of better pair values in the respective quadrants are .0001 and .0044 for unsignedPD and signedPD respectively

DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries-6

<p><b>Copyright information:</b></p><p>Taken from "DNA deformability changes of single base pair mutants within CDE binding sites in centromere DNA correlate with measured chromosomal loss rates and CDE binding site symmetries"</p><p>BMC Molecular Biology 2006;7():12-12.</p><p>Published online 16 Mar 2006</p><p>PMCID:PMC1434758.</p><p></p>sites are marked with an asterisk and palindromic regions with bolded arrows. In the case of CDEI, symmetry is between positions 5 and 6. For CDEIII, symmetry centers on position 14, the central conserved cytosine