Estimating the Value of Medal Success at the 2010 Winter Olympic Games

We estimate Canadians’ willingness to pay (WTP) for success by Team Canada in the 2010 Winter Olympics. The Canadian government subsidized elite athletes in the run up to the 2010 Games through the Own the Podium program, which was designed to increase Canada’s medal count. WTP estimates from a contingent valuation method (CVM) study using data from nationally representative surveys before and after the Games suggest that Own the Podium generated intangible benefits of between 3 and 5 times its cost. The aggregate value of the intangible benefits generated by the program was between $719 million and$3.4 billion. Key Words: Olympic Games, contingent valuation method, willingness to pay

Shorebirds Breed in Unusually High Densities in the Teshekpuk Lake Special Area, Alaska

On the Arctic Coastal Plain of the National Petroleum Reserve-Alaska (NPR-A), the Teshekpuk Lake Special Area (TLSA) was recognized to protect outstanding wildlife values. Although information has accumulated on the TLSA’s value to caribou and waterfowl, its importance to breeding shorebirds remains largely unquantified. Therefore, we undertook a broad-scale ground study to estimate the population size and density of shorebirds breeding in the TLSA. From a series of plot surveys conducted from 2006 to 2008, we estimated a detection-adjusted total breeding population of more than 573 000 shorebirds and an overall density of 126 shorebirds/km2. Most shorebird species had their greatest densities on the Outer Coastal Plain or had approximately equal densities on Outer and Inner Coastal Plains; only two species had their greatest densities on the Inner Coastal Plain. The greatest densities of breeding shorebirds occurred immediately around Teshekpuk Lake. The TLSA supported more than 10% of the biogeographic populations of black-bellied plover (Pluvialis squatarola), semipalmated sandpiper (Calidris pusilla), and dunlin (C. alpina). Breeding shorebird density in the TLSA is one of the highest in the NPR-A, on Alaska’s North Slope, and throughout the circumpolar Arctic. Our results, coupled with previous information on waterfowl and caribou, indicate that the area around Teshekpuk Lake and the recognized goose molting area northeast of the lake should be protected from oil and gas development.Sur la plaine côtière arctique de la réserve pétrolière nationale-Alaska (NPRA), la région spéciale du lac Teshekpuk (TLSA) a été créée dans le but de protéger les valeurs exceptionnelles de la faune. Même s’il existe beaucoup d’information sur la valeur du caribou et de la sauvagine de la TLSA, l’importance qu’elle revêt en matière d’oiseaux de rivage nicheurs demeure peu quantifiée. Nous avons par conséquent entrepris de faire une étude sur le terrain à grande échelle pour estimer la taille et la densité de la population d’oiseaux de rivage nichant dans la TLSA. À partir d’une série d’enquêtes réalisées de 2006 à 2008, nous avons estimé que le total redressé en fonction de la détection de la population nicheuse s’établissait à plus de 573 000 oiseaux de rivage, et que la densité générale s’élevait à 126 oiseaux de rivage/km2. Les plus grandes densités de la plupart des espèces d’oiseaux de rivage se trouvaient sur la plaine côtière extérieure ou encore, les densités étaient environ égales entre les plaines côtières intérieure et extérieure. Seulement deux espèces avaient leurs plus fortes densités sur la plaine côtière intérieure. Les plus grandes densités d’oiseaux de rivage se manifestaient immédiatement autour du lac Teshekpuk. La TLSA accueillait plus de 10 % des populations biogéographiques de pluviers argentés (Pluvialis squatarola), de bécasseaux semipalmés (Calidris pusilla) et de bécasseaux variables (C. alpina). La densité d’oiseaux nicheurs dans la TLSA est l’une des plus élevées de la NPR-A, sur le versant nord de l’Alaska et à l’échelle de l’Arctique circumpolaire. Nos résultats, jumelés à l’information obtenue antérieurement au sujet de la sauvagine et du caribou, indiquent que la région autour du lac Teshekpuk et la région reconnue pour la mue des oies au nord-est du lac devraient être protégées contre la mise en valeur pétrolière et gazière

Cdc13 OB2 Dimerization Required for Productive Stn1 Binding and Efficient Telomere Maintenance

SummaryCdc13 is an essential yeast protein required for telomere length regulation and genome stability. It does so via its telomere-capping properties and by regulating telomerase access to the telomeres. The crystal structure of the Saccharomyces cerevisiae Cdc13 domain located between the recruitment and DNA binding domains reveals an oligonucleotide-oligosaccharide binding fold (OB2) with unusually long loops extending from the core of the protein. These loops are involved in extensive interactions between two Cdc13 OB2 folds leading to stable homodimerization. Interestingly, the functionally impaired cdc13-1 mutation inhibits OB2 dimerization. Biochemical assays indicate OB2 is not involved in telomeric DNA or Stn1 binding. However, disruption of the OB2 dimer in full-length Cdc13 affects Cdc13-Stn1 association, leading to telomere length deregulation, increased temperature sensitivity, and Stn1 binding defects. We therefore propose that dimerization of the OB2 domain of Cdc13 is required for proper Cdc13, Stn1, Ten1 (CST) assembly and productive telomere capping

Distribution of Breeding Shorebirds on the Arctic Coastal Plain of Alaska

Available information on the distribution of breeding shorebirds across the Arctic Coastal Plain of Alaska is dated, fragmented, and limited in scope. Herein, we describe the distribution of 19 shorebird species from data gathered at 407 study plots between 1998 and 2004. This information was collected using a single-visit rapid area search technique during territory establishment and early incubation periods, a time when social displays and vocalizations make the birds highly detectable. We describe the presence or absence of each species, as well as overall numbers of species, providing a regional perspective on shorebird distribution. We compare and contrast our shorebird distribution maps to those of prior studies and describe prominent patterns of shorebird distribution. Our examination of how shorebird distribution and numbers of species varied both latitudinally and longitudinally across the Arctic Coastal Plain of Alaska indicated that most shorebird species occur more frequently in the Beaufort Coastal Plain ecoregion (i.e., closer to the coast) than in the Brooks Foothills ecoregion (i.e., farther inland). Furthermore, the occurrence of several species indicated substantial longitudinal directionality. Species richness at surveyed sites was highest in the western portion of the Beaufort Coastal Plain ecoregion. The broad-scale distribution information we present here is valuable for evaluating potential effects of human development and climate change on Arctic-breeding shorebird populations.Les renseignements qui existent en matière de répartition des oiseaux de rivage en reproduction sur la plaine côtière de l’Arctique en Alaska sont anciens, fragmentés et restreints. Ici, nous décrivons la répartition de 19 espèces d’oiseaux de rivage à partir de données recueillies à 407 lieux de recherche entre 1998 et 2004. Cette information a été recueillie grâce à une technique de recherche consistant en une seule visite rapide durant les périodes d’établissement du territoire et de début d’incubation, périodes pendant lesquelles les comportements sociaux et les vocalisations permettent de bien repérer les oiseaux. Nous décrivons la présence ou l’absence de chaque espèce, de même que le nombre général d’espèces, ce qui procure une perspective régionale de la répartition des oiseaux de rivage. Nous comparons et contrastons nos cartes de répartition des oiseaux de rivage à celles d’études antérieures, en plus de décrire les tendances les plus marquées en matière de répartition des oiseaux de rivage. Notre examen de la variation latitudinale et longitudinale en matière de répartition et de nombre d’espèces d’oiseaux de rivage à l’échelle de la plaine côtière arctique de l’Alaska nous a permis de constater que la plupart des espèces d’oiseaux de rivage se manifestaient plus souvent dans la région écologique de la plaine côtière de Beaufort (c’est-à-dire plus proche de la côte) que dans la région écologique des contreforts de Brooks (c’est-à-dire plus à l’intérieur des terres). Par ailleurs, l’occurrence de plusieurs espèces indiquait une directionalité longitudinale substantielle. La richesse des espèces aux sites à l’étude était à son meilleur dans la partie ouest de la région écologique de la plaine côtière de Beaufort. Les renseignements sur la répartition à grande échelle que nous présentons ici jouent un rôle dans l’évaluation des effets éventuels des travaux de mise en valeur par l’être humain et du changement climatique sur les populations d’oiseaux de rivage en reproduction de l’Arctique

An Open System for Social Computation

Part of the power of social computation comes from using the collective intelligence of humans to tame the aggregate uncertainty of (otherwise) low veracity data obtained from human and automated sources. We have witnessed a surge in development of social computing systems but, ironically, there have been few attempts to generalise across this activity so that creation of the underlying mechanisms themselves can be made more social. We describe a method for achieving this by standardising patterns of social computation via lightweight formal specifications (we call these social artifacts) that can be connected to existing internet architectures via a single model of computation. Upon this framework we build a mechanism for extracting provenance meta-data across social computations

Composite Fermions, Edge Currents and the Fractional Quantum Hall Effect

We present a theory of composite fermion edge states and their transport properties in the fractional and integer quantum Hall regimes. We show that the effective electro-chemical potentials of composite fermions at the edges of a Hall bar differ, in general, from those of electrons. An expression for the difference is given. Composite fermion edge states of three different types are identified. Two of the three types have no analog in previous theories of the integer or fractional quantum Hall effect. The third type includes the usual integer edge states. The direction of propagation of the edge states agrees with experiment. The present theory yields the observed quantized Hall conductances at Landau level filling fractions p/(mp+-1), for m=0,2,4, p= 1,2,3,... It explains the results of experiments that involve conduction across smooth potential barriers and through adiabatic constrictions, and of experiments that involve selective population and detection of fractional edge channels. The relationship between the present work and Hartree theories of composite fermion edge structure is discussed.Comment: 19 pages + 6 figures. Self-unpacking uuencoded postscript. To appear in Physical Review B. Revised version has more details in the Appendix and a discussion of one more experiment in Section

Rudimentary G-Quadruplex-Based Telomere Capping In Saccharomyces Cerevisiae

Telomere capping conceals chromosome ends from exonucleases and checkpoints, but the full range of capping mechanisms is not well defined. Telomeres have the potential to form G-quadruplex (G4) DNA, although evidence for telomere G4 DNA function in vivo is limited. In budding yeast, capping requires the Cdc13 protein and is lost at nonpermissive temperatures in cdc13-1 mutants. Here, we use several independent G4 DNA-stabilizing treatments to suppress cdc13-1 capping defects. These include overexpression of three different G4 DNA binding proteins, loss of the G4 DNA unwinding helicase Sgs1, or treatment with small molecule G4 DNA ligands. In vitro, we show that protein-bound G4 DNA at a 3\u27 overhang inhibits 5\u27-\u3e 3\u27 resection of a paired strand by exonuclease I. These findings demonstrate that, at least in the absence of full natural capping, G4 DNA can play a positive role at telomeres in vivo

Exploring Human/Animal Intersections: Converging Lines of Evidence in Comparative Models of Aging

At a symposium convened on March 8, 2007 by the Institute on Aging at the University of Pennsylvania, researchers from the University’s Schools of Medicine and Veterinary Medicine explored the convergence of aging research emerging from the two schools. Studies in human patients, animal models, and companion animals have revealed different but complementary aspects of the aging process, ranging from fundamental biologic aspects of aging to the treatment of age-related diseases, both experimentally and in clinical practice. Participants concluded that neither animal nor human research alone will provide answers to most questions about the aging process. Instead, an optimal translational research model supports a bidirectional flow of information from animal models to clinical research

Status of Muon Collider Research and Development and Future Plans

The status of the research on muon colliders is discussed and plans are outlined for future theoretical and experimental studies. Besides continued work on the parameters of a 3-4 and 0.5 TeV center-of-mass (CoM) energy collider, many studies are now concentrating on a machine near 0.1 TeV (CoM) that could be a factory for the s-channel production of Higgs particles. We discuss the research on the various components in such muon colliders, starting from the proton accelerator needed to generate pions from a heavy-Z target and proceeding through the phase rotation and decay ($\pi \to \mu \nu_{\mu}$) channel, muon cooling, acceleration, storage in a collider ring and the collider detector. We also present theoretical and experimental R & D plans for the next several years that should lead to a better understanding of the design and feasibility issues for all of the components. This report is an update of the progress on the R & D since the Feasibility Study of Muon Colliders presented at the Snowmass'96 Workshop [R. B. Palmer, A. Sessler and A. Tollestrup, Proceedings of the 1996 DPF/DPB Summer Study on High-Energy Physics (Stanford Linear Accelerator Center, Menlo Park, CA, 1997)].Comment: 95 pages, 75 figures. Submitted to Physical Review Special Topics, Accelerators and Beam