Bibliometric Analysis of the Published Studies on the Kindling Model between 1980 and 2023

Objective: Kindling is an animal model of epilepsy induced by electrical stimulation of the brain. The present study aimed to present a different perspective with a bibliometric approach by using the literature data on the “Kindling model” related keywords in the Web of Science (WoS) online database between 1980 and 2023. Methods: The bibliometric data were obtained from the online database WoS and analyzed and visualized with the VoS Viewer Program. The bibliometric datasets were analyzed and visualized regarding article productivity numbers according to years, article productivity numbers according to countries, the most used keywords according to authors, and cross-country cooperation. Result: Considering the results of the analysis of the published datasets, 2022 was determined as the year with the highest article productivity, and an acceleration was observed in the publication increase rate on the subject in general. When the order of the countries in the top three in the number of article productivity was examined, the USA, Germany, and Japan are the main countries, respectively. The most used keywords by the authors were determined as “Epilepsy”, “Kindling”, and “Hippocampus”. In the cooperation among countries, it was found that the USA, Germany, and Japan had more cooperation with other countries, respectively. Conclusıon: This study will contribute to the literature by providing a detailed understanding of the research basis, relevant research results, current research boundaries and main research focus in the Kindling Model

Etçi piliçlerde esansiyel yağlar ve/veya humatin yaz sezonunda performans, ince bağırsak mikrobiyel populasyonu ve antikor titreleri üzerine etkisi

This study was conducted to observe the effect of essantial oils and/or humic acids in broilers reared farm condition (without suitable techical equipment) during summer season. A total of two hundred male chicks broilers (Ross-308) aged one day were weighed and randomly allocated to five treatment groups each containing 40 chicks. Each grop was divided into four replicate. Chicks were assigned to the basal diet (CON) and the basal diet supplemented with 250 ppm antibiotic (ANTI), 1000 ppm essential oils (EO), 1500 ppm humic acids (H) and combination of same levels of EO plus humic acids (EO+H) diet until 42 days of age, respectively. The colony forming units (CFU) of Escherichia coli in the digesta of birds fed either the diet supplemented antibiotic and the diet supplemented with essential oils and/or humic acids were significantly lower than in those given control. However, inclusion of essential oil and/or humic acids increased the CFU of Lactobacilli compare to those antibiotic supplementing. Antibody titres against Newcastle Disease Virus (NDV) were tending to numerically increase in all supplemental diets. At the end of the experiment, essential oils and/or humic acids did not show favorable effect in animal performance. Supplements did not alter the carcass traits.Bu araştırma, sıcak yaz aylarında uygun teknik donanım desteğinin olmadığı çiftlik şartlarında beslenen etçi piliç rasyonlarında esansiyel yağ ve/veya humik asit ilavesinin etkilerini gözlemlemek amacıyla yapıldı. Araştırmada, bir günlük yaşta 200 adet (Roos-308) civciv her birinde 40 civciv bulunacak şekilde rasgele dağıltılarak 5 gruba ayrıldı. Her grup dört tekrar grubundan oluşturuldu. Civcivlere temel diyet (kontrol), temel diyete ilave edilen 250 ppm antibiyotik (ANTI), 1000 ppm esansiyel yağ karışımı (EO), 1500 ppm humik asit (H) ve 1000 ppm esansiyel yağ karışımı +1500 ppm humik asit (EO+H) şeklinde oluşturulan yemler 42 gün süreyle yedirildi. Kontrol grubuna göre tüm katkılı gruplardaki piliçlerin bağırsak içeriğinde, Escherichia coli koloni oluşturma birimi (CFU) önemli derecede azaldı. Bununla birlikte, Lactobacilli koloni oluşturma birimi (CFU) bakımından, antibiyotik tüketen tüketen piliçlerin bağırsak içeriğinde, önemli derecede düşüş gözlenirken; esansiyel yağ ve/veya humik asit tüketen gruplarla kontrol grubu arasında bir farklılık gözlenmedi. Newcastle Virusuna (NDV) karşı antikor titresi, katkılı gruplarda kontrole göre artma eğilimi gösterdi. Araştırma sonunda esansiyel yağ ve/veya humik asit ilavesi hayvansal performans ve karkas özellikleri bakımından olumlu bir etki yapmadı

The protective effect of Ferula elaeochytris on age-related erectile dysfunction

Ethnopharmacological relevance Ferula elaeochytris Korovin (FE) is a perennial medicinal plant of Apiaceae family. Ferula elaeochytris Korovin, known as ‘Çakşır’ in Anatolia, is widely used as an aphrodisiac as well as antioxidant, anti-inflammatory, and anti-diabetic. Aim of the study: Erectile dysfunction (ED) is a serious public health problem that has a high prevalence and negatively affects the quality of life in elderly men. In the treatment and prophylaxis of many diseases, because of widely increasing use of plant extracts as therapeutic agents, preclinical studies related to plant extracts are becoming more important by the day. In this study, we aimed to investigate the protective effect of Ferula elaeochytris Korovin (FE) root extract on age-related ED. Materials and methods Seventy-two male Wistar albino rats were equally divided into four groups: 4-month aged rats (Y), 24-month aged rats (AG), and FE-administered (20 and 40 mg/kg/day; oral gavage; over 8 weeks) 24-month aged rats (AG + FE). The measurements included: changes in smooth muscle cells and collagen fibrils, tumor necrosis factor alpha (TNF-α), penile neuronal nitric oxide synthase (nNOS) and endothelial nitric oxide synthase (eNOS) expression, serum testosterone concentrations (ST), neurogenic- and endothelial-dependent relaxations of the corpus cavernosum (CC), intracavernosal pressure/mean arterial pressure (ICP/MAP), area under the curve (total ICP), total antioxidant status (TAS), and total oxidant status (TOS) on corpus cavernosal tissue. Results These results have an important role in the development of ED. ICP/MAP, total ICP, eNOS/nNOS expressions and ST levels increased in AG+40 mg FE group compared to the AG group, whereas TNF-α levels decreased and oxidative and antioxidant parameters balanced. Conclusions Our findings show that FE may have a useful effect on decelerating the development of age-related ED