Association between C-peptide level and microalbuminuria in patients with type 2 diabetes mellitus

Purpose: Latest studies suggest that C-peptide may have a beneficial biological role on diabetic nephropathy. The aim of this study is to analyze whether there is an association between serum C-peptide level and microalbuminuria in type 2 diabetes mellitus (T2DM). Materials and Methods: We enrolled 184 T2DM patents and 46 healthy subjects in this study. Clinical variables and routine biochemical tests along with serum C peptide levels measured after an overnight fasting. Serum C peptide levels between 1.1 and 4.4 accepted as normal. 24-hour-urine samples were investigated and values between 30-300mgwere recorded as microalbuminuria. Pearson correlation analysis were used to determine associations between continuous variables. Results: C peptide levels were not significantly difference in T2DM patients compared to healthy controls. Serum C peptide levels showed positive correlation with insulin and microalbminuria with the Pearson correlation analysis. However, there was no significant association between other variables and C peptide levels. Conclusion: A correlation was found between microalbuminuria and serum C-peptide in this present study. Findings suggest C-peptide is related with renal complications of T2DM patients

Relationship between Levels of Brain-Derived Neurotrophic Factor and Metabolic Parameters in Patients with Type 2 Diabetes Mellitus

Background and Aim. Studies have suggested that brain-derived neurotrophic factor (BDNF) plays a role in glucose and lipid metabolism and inflammation. The aim of this study was to evaluate the relationship between serum BDNF levels and various metabolic parameters and inflammatory markers in patients with type 2 diabetes mellitus (T2DM). Materials and Methods. The study included 88 T2DM patients and 33 healthy controls. Fasting blood samples were obtained from the patients and the control group. The serum levels of BDNF were measured with an ELISA kit. The current paper introduces a receiver-operating characteristic (ROC) generalization curve to identify cut-off for the BDNF values in type 2 diabetes patients. Results. The serum levels of BDNF were significantly higher in T2DM patients than in the healthy controls (206.81 ± 107.32 pg/mL versus 130.84 ± 59.81 pg/mL; P<0.001). They showed a positive correlation with the homeostasis model assessment of insulin resistance (HOMA-IR) (r=0.28; P<0.05), the triglyceride level (r=0.265; P<0.05), and white blood cell (WBC) count (r=0.35; P<0.001). In logistic regression analysis, age (P<0.05), body mass index (BMI) (P<0.05), C-reactive protein (CRP) (P<0.05), and BDNF (P<0.01) were independently associated with T2DM. In ROC curve analysis, BDNF cut-off was 137. Conclusion. The serum BDNF level was higher in patients with T2DM. The BDNF had a cut-off value of 137. The findings suggest that BDNF may contribute to glucose and lipid metabolism and inflammation

Evaluation of Helicobacter pylori Infection, Neutrophil–Lymphocyte Ratio and Platelet–Lymphocyte Ratio in Dyspeptic Patients

Recent studies have shown a correlation between Helicobacter pylori (H. Pylori) infection and the neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). The aim of this study was to investigate the relationship between H. Pylori infection and hematimetric indices in patients with dyspepsia symptoms. Overall, 448 patients who underwent gastroscopy were analyzed retrospectively. Histopathological evaluation of biopsies according to H. pylori presence was classified as H. Pylori positive and negative groups, which are analyzed in relation with hematimetric indices. NLR and PLR measurements did not show a statistically significant difference between H. pylori negative and positive groups (p &gt; 0.05). NLR revealed a negative correlation between hemoglobin (HGB), iron, and ferritin measurements in the correlation analysis of the H. Pylori positive group (r = −0.133, p = 0.031; r = −0.270, p = 0.002; r = −0.162, p = 0.032). Again, with PLR, there was a negative correlation between HGB, mean corpuscular volume (MCV), iron, and ferritin measurements (r = −0.310, p = 0.001, r = −0.187, p = 0.002, r = −0.335, p = 0.001; r = −0.290; p = 0.001). The results of our study do not reveal an association between H. pylori presence and inflammatory response, which is evaluated by NLR and PLR measurements in patients with dyspepsia. However, low serum iron and ferritin values of H. pylori-positive patients suggest the effect of H. pylori on iron metabolism

Effect of abdominal fat distribution on severity of acute pancreatitis

Aim of the study: Obesity is a well-determined risk factor for acute pancreatitis. Increased visceral fat has been shown to increase the proinflammatory environment experienced by patients. In this study, we aimed to research the correlation between abdominal fat distribution parameters measured with computed tomography (CT) and severity of acute pancreatitis (AP)

Endocan: A Biomarker for Hepatosteatosis in Patients with Metabolic Syndrome

Background. Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, which has recently been mentioned as an independent cardiovascular risk factor. Objectives. Endocan is a novel molecule of endothelial dysfunction. We aimed to evaluate the associations of serum endocan levels with the hepatic steatosis index (HSI), fatty liver index (FLI), and degrees of hepatosteatosis in patients with metabolic syndrome with NAFLD. Design and Setting. This cross-sectional prospective study was performed in the outpatient clinic of an internal medicine department. Methods. The study included 40 patients with metabolic syndrome with NAFLD as noted using hepatic ultrasound and 20 healthy controls. Secondary causes of fatty liver were excluded. FLI and HSI calculations were recorded. Serum endocan level values were obtained after overnight fasting. Results. Higher values of HSI and FLI were found in the NAFLD groups than in the control groups (p<0.001). Five (12.5%) of 20 patients with liver steatosis had grade 1 liver steatosis, 15 (37.5%) patients had grade 2 liver steatosis, and 20 (50%) patients had grade 3 liver steatosis. Serum endocan levels were lower in patients with NAFLD compared with the healthy controls (146.56±133.29 pg/mL vs. 433.71±298.01 pg/mL, p<0.001). ROC curve analysis suggested that the optimum endocan value cutoff point for NAFLD was 122.583 pg/mL (sensitivity: 71.79%, specificity: 90%, PPV: 93.3%, and NPV: 62.1%). Conclusion. Serum endocan concentrations are low in patients with NAFLD, and the optimum cutoff point is 122.583 pg/mL. HSI and FLI were higher in patients with NAFLD; however, there was no correlation with serum endocan

The Evaluation of Liver Steatosis with Transient Elastography in Metabolic Syndrome and the Relationship Between Serum Endorphin Levels

Objective: Studies in recent times researching the correlation between serum endotrophinlevel and Type 2 DM have focused on the association of fatty liver with metabolic syndrome.This study aims to research the correlation between serum endotrophin levels, defined asa marker of metabolic dysregulation, with nonalcoholic fatty liver in metabolic syndromepatients, with increasing prevalence.Methods: Our prospective study included 40 patients (24 females and 16 males) with metabolicsyndrome attending the internal medicine clinic and 20 healthy volunteers (ten femalesand ten males). Evaluation of patients in terms of liver steatosis used transabdominal ultrasonographywith a Toshiba 500 Aplio brand model ultrasound device with 10 MHz convexprobe with transient elastography method. Fatty Liver Index and Hepatic Steatosis Index(HSI) were calculated on the basis sample analyses. The endotrophin levels were studiedwith a Sunred enzyme-linked ımmunosorbent assay kit.Results: Endotrophin levels were found to be lower in the group with metabolic syndromecompared to the healthy group and results were statistically significant different (p<0.001).When the mean elastography results for the groups (in m/s and kPa) are compared, therewere statistically significant differences found (p=0.001, p<0.001). There were statisticallysignificant differences between HSI score with serum insulin levels and homeostasis modelassessment results.Conclusion: In our study, a correlation was not found between endotrophin levels and fattyliver. Endotrophin is a parameter with newly discovered effects and is being researched forapplicability and reliability in clinical practice

Effect of The Atherogenic Index of Plasma on Microvascular Complications Associated with Type 2 Diabetes Mellitus

Objective: The aim of this study was to evaluate the effects of the atherogenic index of plasma (AIP) on the microvascular complications of type 2 diabetes mellitus (DM) patients who applied to our internal medicine clinic. Methods: The study included 212 type 2 DM patients and 34 healthy controls who were compatible according to age and sex. Age, sex, duration of illness, treatment for diabetes and other illnesses associated with diabetes, height, weight, retinopathy, nephropathy, neuropathy, hypertension, and hyperlipidemia were recorded at the beginning of the study. AIP is calculated as the logarithm of the ratio between the triglyceride value and high density lipoprotein value (in mg/dL). Results: AIP and triglyceride levels of the type 2 DM patients were higher than those of the control group. Also, the study determined that 25.7% of the patients have retinopathy, 31.6% have neuropathy, 29.1% have microalbuminuria, and 3.9% have macroalbuminuria. If we accept that there is a complications who have one of these complications in this three, there is 62.6% of the patients have complications. A statistically significant correlation was determined with these complications and lipid subgroups such as AIP and low density lipoprotein (LDL). Conclusion: The relationship between AIP and only nephropathy, which is a complication in type 2 DM patients, was determined

Serum 25-hydroxyvitamin d levels and risk of incident heart failure in patients with newly diagnosed hypertension

Backround and aims: Both vitamin D deficiency and hypertension widely effects general population. The studies about the interaction between these two condition is intriguing. This study aims to determine the association between levels of 25-hydroxyvitamin D (25[OH]D) in the sera of newly diagnosed hypertension patients and risk of incident heart failure. Methods: We recruited 50 newly diagnosed hypertension patients and 20 healthy controls and assessed them for left ventricular diastolic dysfunction by echocardiography. Patient blood was tested for 25(OH)D concentrations. Patient group is divided into two subgroups: Group 1 subjects = 20 ng/ml 25(OH). Results: We found that serum 25(OH)D (ng/ml) levels of patient group were significantly lower than the control group (15.63 +/- 5.71; p<0.004). E/A, and diastolic diameter were significantly different (p<0.05) between the Group 1 and Group 2. EF, diastolic diameter, systolic diameter, systolic arterial pressure, and gender had significant effects on the multivariate model (p<0.05). Conclusion: Study results support the theory that vitamin D deficiency plays a role in the development of heart failure. Our study found a relationship between 25(OH)D vitamin levels and left ventricular diastolic dysfunction in newly diagnosed hypertension patients

Effect of the Atherogenic Index of Plasma on Microvascular Complications Associated with Type 2 Diabetes Mellitus

Objective: The aim of this study was to evaluate the effects of the atherogenic index of plasma (AIP) on the microvascular complications of type 2 diabetes mellitus (DM) patients who applied to our internal medicine clinic. Methods: The study included 212 type 2 DM patients and 34 healthy controls who were compatible according to age and sex. Age, sex, duration of illness, treatment for diabetes and other illnesses associated with diabetes, height, weight, retinopathy, nephropathy, neuropathy, hypertension, and hyperlipidemia were recorded at the beginning of the study. AIP is calculated as the logarithm of the ratio between the triglyceride value and high density lipoprotein value (in mg/dL). Results: AIP and triglyceride levels of the type 2 DM patients were higher than those of the control group. Also, the study determined that 25.7% of the patients have retinopathy, 31.6% have neuropathy, 29.1% have microalbuminuria, and 3.9% have macroalbuminuria. If we accept that there is a complications who have one of these complications in this three, there is 62.6% of the patients have complications. A statistically significant correlation was determined with these complications and lipid subgroups such as AIP and low density lipoprotein (LDL). Conclusion: The relationship between AIP and only nephropathy, which is a complication in type 2 DM patients, was determined

Tip 2 diyabetes mellituslu hastalarda C peptid ile mikroalbuminüri ilişkisi

Purpose: Latest studies suggest that C-peptide may have a beneficial biological role on diabetic nephropathy. The aim of this study is to analyze whether there is an association between serum C-peptide level and microalbuminuria in type 2 diabetes mellitus (T2DM). Materials and Methods: We enrolled 184 T2DM patents and 46 healthy subjects in this study. Clinical variables and routine biochemical tests along with serum C peptide levels measured after an overnight fasting. Serum C peptide levels between 1.1 and 4.4 accepted as normal. 24-hour-urine samples were investigated and values between 30-300mgwere recorded as microalbuminuria. Pearson correlation analysis were used to determine associations between continuous variables. Results: C peptide levels were not significantly difference in T2DM patients compared to healthy controls. Serum C peptide levels showed positive correlation with insulin and microalbminuria with the Pearson correlation analysis. However, there was no significant association between other variables and C peptide levels. Conclusion: A correlation was found between microalbuminuria and serum C-peptide in this present study. Findings suggest C-peptide is related with renal complications of T2DM patients