The Dynamical Yang-Baxter Relation and the Minimal Representation of the Elliptic Quantum Group

In this paper, we give the general forms of the minimal $L$ matrix (the elements of the $L$-matrix are $c$ numbers) associated with the Boltzmann weights of the $A_{n-1}^1$ interaction-round-a-face (IRF) model and the minimal representation of the $A_{n-1}$ series elliptic quantum group given by Felder and Varchenko. The explicit dependence of elements of $L$-matrices on spectral parameter $z$ are given. They are of five different forms (A(1-4) and B). The algebra for the coefficients (which do not depend on $z$) are given. The algebra of form A is proved to be trivial, while that of form B obey Yang-Baxter equation (YBE). We also give the PBW base and the centers for the algebra of form B.Comment: 23 page

Fully transparent organic transistors with junction-free metallic network electrodes

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ROCK Inhibitor Y-27632 Suppresses Dissociation-Induced Apoptosis of Murine Prostate Stem/Progenitor Cells and Increases Their Cloning Efficiency

Activation of the RhoA/ROCK signaling pathway has been shown to contribute to dissociation-induced apoptosis of embryonic and neural stem cells. We previously demonstrated that approximately 1 out of 40 Lin−Sca-1+CD49fhigh (LSC) prostate basal epithelial cells possess the capacities of stem cells for self-renewal and multi-lineage differentiation. We show here that treating LSC cells with the ROCK kinase inhibitor Y-27632 increases their cloning efficiency by 8 fold in an in vitro prostate colony assay. Y-27632 treatment allows prostate colony cells to replate efficiently, which does not occur otherwise. Y-27632 also increases the cloning efficiency of prostate stem cells in a prostate sphere assay and a dissociated prostate cell regeneration assay. The increased cloning efficiency is due to the suppression of the dissociation-induced, RhoA/ROCK activation-mediated apoptosis of prostate stem cells. Dissociation of prostate epithelial cells from extracellular matrix increases PTEN activity and attenuates AKT activity. Y-27632 treatment alone is sufficient to suppress cell dissociation-induced activation of PTEN activity. However, this does not contribute to the increased cloning efficiency, because Y-27632 treatment increases the sphere-forming unit of wild type and Pten null prostate cells to a similar extent. Finally, knocking down expression of both ROCK kinases slightly increases the replating efficiency of prostate colony cells, corroborating that they play a major role in the Y-27632 mediated increase in cloning efficiency. Our study implies that the numbers of prostate cells with stem/progenitor activity may be underestimated based on currently employed assays, supports that dissociation-induced apoptosis is a common feature of embryonic and somatic stem cells with an epithelial phenotype, and highlights the significance of environmental cues for the maintenance of stem cells

Genome-wide association analysis identifies 30 new susceptibility loci for schizophrenia

We conducted a genome-wide association study (GWAS) with replication in 36,180 Chinese individuals and performed further transancestry meta-analyses with data from the Psychiatry Genomics Consortium (PGC2). Approximately 95% of the genome-wide significant (GWS) index alleles (or their proxies) from the PGC2 study were overrepresented in Chinese schizophrenia cases, including ∼50% that achieved nominal significance and ∼75% that continued to be GWS in the transancestry analysis. The Chinese-only analysis identified seven GWS loci; three of these also were GWS in the transancestry analyses, which identified 109 GWS loci, thus yielding a total of 113 GWS loci (30 novel) in at least one of these analyses. We observed improvements in the fine-mapping resolution at many susceptibility loci. Our results provide several lines of evidence supporting candidate genes at many loci and highlight some pathways for further research. Together, our findings provide novel insight into the genetic architecture and biological etiology of schizophrenia

Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration

Contains fulltext : 184186.pdf (publisher's version ) (Open Access)16 p

An Input-to-State Stability-Based Load Restoration Approach for Isolated Power Systems

An isolated power system (IPS) is usually operated under a bad environment and is influenced by external disturbances. Advanced load restoration technology is an important way to enhance the survivability and reliability of IPS. This paper proposes a fast load restoration approach based on Input-to-State Stability (ISS) theory for IPS. The method can recover load after an outage happens in an IPS under severe perturbations. In the proposed restoration approach, both stability and security constraints are considered based on the ISS theory, which can guarantee the stable and secure operation of IPS during the restoration dynamic process. These constraints have good adaptability for topology transformation and operation status transition of IPS. A heuristic approach to efficiently solve the load restoration problem is proposed, where bisection search is used to check the feasibility of the loads to be restored. Case studies on a typical IPS are used to verify the proposed method