A MonoSLAM Approach to Lane Departure Warning System

Lane Departure Warning (LDW) systems are one of the widely researched topics under Advanced Driver Assistance Systems (ADAS), because they are seen as the most viable way to prevent the traffic accidents caused by involuntary lane departures from happening. Various methods and algorithms used for lane tracking to be used in LDW in the literature; however, most of them only track the lanes or the position of the vehicle inside the lane. This article introduces MonoSLAM based method for LDW design, assuming that the camera is moving in a previously unknown scene. While applying this method, a constant lateral velocity model for the vehicle is used, which assumes that the vehicle is exposed to undetermined Gaussian lateral accelerations. As the first output, the localization of the vehicle on the road is achieved. Moreover, the method is applied with a low cost webcam attached on a vehicle. Five control points for each lane is used to track the lanes and these control points are modelled as if they have a constant position. Detection is made with steerable filters exploiting the state covariance from EKF to make detection more robust. In addition to this, off-line experimental results are given for 200 frames. Results of lane slope on image plane compared with ground truth marked manually for performance benchmarking and localization estimation of a scenario similar to loop closure test is given

Distribution of Lymphomas in Turkey: Data Of 4239 Cases From a Single Institution Using the Who Classification

Background/aim: Lymphoma cases diagnosed at one of the largest tertiary reference centers in Turkey were reviewed and findings were compared to those reported from other regions of the world. Materials and methods: Lymphomas diagnosed between 2000 and 2017 in the pathology laboratory of I lacettepe University were identified. A total of 4239 cases were analyzed. The WIIO 2008 classification was used. Results: Hodgkin lymphomas accounted for almost 20% of cases. T-cell lymphomas were much more frequent (23% of our non- Hodgkin lymphoma (NHL) cases) in comparison to all other regions of the world. The reason for this difference was the high frequency of mycosis fungoides (MF) cases. We had significantly more cases of high-grade B-cell lymphoma (43.9% of NHLs) and fewer cases of low-grade B-cell lymphoma (33.5% of NHLs) in comparison to the rates of developed regions of the world and the reverse was true when compared to developing parts of the world. Burkitt lymphoma frequency (4% of NHLs) was also higher than in most parts of the world. Conclusion: Our data reveal that the frequency of MF, Burkitt lymphoma, and Hodgkin lymphoma are considerably higher, whereas follicular lymphoma rates are considerably lower than in most other parts of the world.WoSScopu

Posttranscriptional Manipulation of Terc Reverses Molecular Hallmarks of Telomere Disease

The telomerase RNA component (TERC) is a critical determinant of cellular self-renewal. Poly(A)-specific ribonuclease (PARN) is required for posttranscriptional maturation of TERC. PARN mutations lead to incomplete 3' end processing and increased destruction of nascent TERC RNA transcripts, resulting in telomerase deficiency and telomere diseases. Here, we determined that overexpression of TERC increased telomere length in PARN-deficient cells and hypothesized that decreasing posttranscriptional 3' oligo-adenylation of TERC would counteract the deleterious effects of PARN mutations. Inhibition of the noncanonical poly(A) polymerase PAP-associated domain-containing 5 (PAPD5) increased TERC levels in PARN-mutant patient cells. PAPD5 inhibition was also associated with increases in TERC stability, telomerase activity, and telomere elongation. Our results demonstrate that manipulating posttranscriptional regulatory pathways may be a potential strategy to reverse the molecular hallmarks of telomere disease.WoSScopu

Poly(A)-Specific Ribonuclease (Parn) Mediates 3 '-End Maturation of the Telomerase Rna Component

Mutations in the PARN gene (encoding poly(A)-specific ribonuclease) cause telomere diseases including familial idiopathic pulmonary fibrosis (IPF) and dyskeratosis congenita(1,2), but how PARN deficiency impairs telomere maintenance is unclear. Here, using somatic cells and induced pluripotent stem cells (iPSCs) from patients with dyskeratosis congenita with PARN mutations, we show that PARN is required for the 3'-end maturation of the telomerase RNA component (TERC). Patient-derived cells as well as immortalized cells in which PARN is disrupted show decreased levels of TERC. Deep sequencing of TERC RNA 3' termini shows that PARN is required for removal of post-transcriptionally acquired oligo(A) tails that target nuclear RNAs for degradation. Diminished TERC levels and the increased proportion of oligo(A) forms of TERC are normalized by restoring PARN, which is limiting for TERC maturation in cells. Our results demonstrate a new role for PARN in the biogenesis of TERC and provide a mechanism linking PARN mutations to telomere diseases.Wo