Gertrudis Gómez de Avellaneda: biografía, bibliografía e iconografía, incluyendo muchas cartas, inéditas o publicadas, escritas por la gran poetisa o dirigidas a ella, y sus memorias

292 p., [11] h. de lám

Breast imaging technology: Recent advances in imaging endogenous or transferred gene expression utilizing radionuclide technologies in living subjects - applications to breast cancer

A variety of imaging technologies is being investigated as tools for studying gene expression in living subjects. Two technologies that use radiolabeled isotopes are single photon emission computed tomography (SPECT) and positron emission tomography (PET). A relatively high sensitivity, a full quantitative tomographic capability, and the ability to extend small animal imaging assays directly into human applications characterize radionuclide approaches. Various radiolabeled probes (tracers) can be synthesized to target specific molecules present in breast cancer cells. These include antibodies or ligands to target cell surface receptors, substrates for intracellular enzymes, antisense oligodeoxynucleotide probes for targeting mRNA, probes for targeting intracellular receptors, and probes for genes transferred into the cell. We briefly discuss each of these imaging approaches and focus in detail on imaging reporter genes. In a PET reporter gene system for in vivo reporter gene imaging, the protein products of the reporter genes sequester positron emitting reporter probes. PET subsequently measures the PET reporter gene dependent sequestration of the PET reporter probe in living animals. We describe and review reporter gene approaches using the herpes simplex type 1 virus thymidine kinase and the dopamine type 2 receptor genes. Application of the reporter gene approach to animal models for breast cancer is discussed. Prospects for future applications of the transgene imaging technology in human gene therapy are also discussed. Both SPECT and PET provide unique opportunities to study animal models of breast cancer with direct application to human imaging. Continued development of new technology, probes and assays should help in the better understanding of basic breast cancer biology and in the improved management of breast cancer patients

Gene therapy for carcinoma of the breast: Genetic ablation strategies

The gene therapy strategy of mutation compensation is designed to rectify the molecular lesions that are etiologic for neoplastic transformation. For dominant oncogenes, such approaches involve the functional knockout of the dysregulated cellular control pathways provoked by the overexpressed oncoprotein. On this basis, molecular interventions may be targeted to the transcriptional level of expression, via antisense or ribozymes, or post-transcriptionally, via intracellular single chain antibodies (intrabodies). For carcinoma of the breast, these approaches have been applied in the context of the disease linked oncogenes erbB-2 and cyclin D(1), as well as the estrogen receptor. Neoplastic revision accomplished in modal systems has rationalized human trials on this basis

Marci-Zuerii Boxhornii Chronologia Praecipuorum Universi Orbis Imperiorum, Regnorum, Principatuum, Rerumque Publicarum Ortus, Mutationes, Atque Occasus Designans

edita atque Plurimis Additionibus & Continuatione usque in praesentem annum aucta A Daniele Hartnaccio Pomerano ..

Muyden

Planimetrische kaart met zijaangezicht van de bebouwing. Renvoi van gebouwen. Zuidzuidoost boven. Oorspronkelijk op het blad tevens afbeeldingen van Naerden, Weesp en 't Huys te Muyden De kaart werd oorspronkelijk uitgegeven in: Tonneel ofte Beschrijvinghe des landts ende steden van Hollandt / Marcus Zuerus Boxhorn. 1634 Afkomstig uit: Toonneel der steden van de Vereenighde Nederlanden, met hare beschrijvingen. 't Amsterdam : Joan Blaeu, 1652 Atlantes Neerlandici. volume 1 / comp. and ed. by C. Koeman. p. 324-325 Joan Blaeu : Toonneel der steden ... : historisch vergelijkende beschouwingen / ingeleid door B. van 't Hoff. Amsterdam 1966 Schaalstok in pedes geometrici.

L. Ivlivs Florvs, P. Vell. Patercvlvs, Sex. Avr. Victor, Sex. Rvfvs Festvs, Messala Corvinvs, Evtropivs, Cassiodorvs, Fasti Capitolini / M. Boxhorn-Zuerius animadversionibus illustravit

L. IVLIVS FLORVS, P. VELL. PATERCVLVS, SEX. AVR. VICTOR, SEX. RVFVS FESTVS, MESSALA CORVINVS, EVTROPIVS, CASSIODORVS, FASTI CAPITOLINI / M. BOXHORN-ZUERIUS ANIMADVERSIONIBUS ILLUSTRAVIT Historiæ Avgvstæ Scriptorvm Latinorvm Minorvm Pars Prima (-) L. Ivlivs Florvs, P. Vell. Patercvlvs, Sex. Avr. Victor, Sex. Rvfvs Festvs, Messala Corvinvs, Evtropivs, Cassiodorvs, Fasti Capitolini / M. Boxhorn-Zuerius animadversionibus illustravit (Ps. [1:]) (1) Einband (1) Titelblatt (12) Widmung (14) Dedicatio. (15) L. Annaei Flori vita et scripta (27) Lvcii Annaei: Liber Primvs. - Liber Qvartvs. (36) Notae in florvm. (214) Index (249) Historiae Romanae: Liber Primvs. - Liber Secvndvs. (258) Animadversiones in velleivm: Librvm Primvm. - Librvm Secvndvm (438) Historiae Avgvstae scriptorvm latinorvm minorvm (448) Fotodokumentation (565

Marci Zuerii Boxhornii Orationes tres, De theologia paganorum, fabulis potarum, et animarum inmortalitate, p. 137-178. Antonius Brunus Liber de anima, p. 178-179. Annotationes in Quaestiones Romanas Plutarchi, p. 87-100 de la segunda secuencia de pag.

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