Computerized cognitive behavioral therapy for anxiety and depression in farming communities: mixed methods feasibility study of participant use and acceptability

Background: Farmers have higher rates of depression than nonfarmers and higher rates of suicide than the general population. Several barriers to help seeking have been identified in farmers, which may be overcome by offering web-based mental health support. Computerized cognitive behavioral therapy (cCBT) is an effective intervention used to prevent and treat mild to moderate depression but has not been evaluated in the farming community. Objective: This study explored the feasibility of delivering a cCBT course tailored to farmers using a mixed methods approach. Methods: Farmers (aged ≥18 years) with no, minimal, or moderately severe depressive symptoms (Patient Health Questionnaire–9 [PHQ-9] score <20) were recruited using web-based and offline advertisements and given access to a cCBT course consisting of 5 core modules and automated and personalized email support. Depression (PHQ-9), anxiety (General Anxiety Disorder–7), and social functioning (Work and Social Adjustment Scale) were measured at baseline and the 8-week follow-up. Wilcoxon signed rank tests assessed changes in scores for all outcome measures over time. Telephone interviews focusing on participant use and satisfaction with the course were analyzed using thematic analysis. Results: Overall, 56 participants were recruited; 27 (48%) through social media. Overall, 62% (35/56) of participants logged into the course. At baseline, almost half of the participants reported experiencing minimal depressive symptoms (25/56, 45%) and mild anxiety (25/56, 45%), and just over half (30/56, 54%) reported mild to moderate functional impairment. Posttreatment data were available for 27% (15/56) of participants (41/56, 73% attrition rate). On average, participants experienced fewer depressive symptoms (P=.38) and less functional impairment (P=.26) at the 8-week follow-up; these results were not statistically significant. Participants experienced significantly fewer symptoms of anxiety at the 8-week follow-up (P=.02). Most participants (13/14, 93%) found the course helpful and easy to access (10/13, 77%) and the email support helpful (12/14, 86%). Qualitative interviews identified heavy workloads and mental health stigma within the farming community as barriers to help seeking. Participants thought that web-based support would be helpful, being convenient and anonymous. There were concerns that older farmers and those with limited internet connections may have difficulty accessing the course. Improvements regarding the layout and content of the course were suggested. Dedicated support from someone with farming knowledge was recommended to improve retention. Conclusions: cCBT may be a convenient way of supporting mental health within farming communities. However, challenges in recruiting and retaining farmers may indicate that cCBT supported only by email may not be an acceptable mode of mental health care delivery for many; however, it was valued by respondents. Involving farming organizations in planning, recruitment, and support may address these issues. Mental health awareness campaigns targeting farming communities may also help reduce stigma and improve recruitment and retention

Multidisciplinary Investigations of Alpine Ice Patches in Southwest Yukon, Canada: Paleoenvironmental and Paleobiological Investigations

Since the discovery of dung-rich alpine ice patches in southwest Yukon in 1997, continuing multidisciplinary studies have provided a unique window on the biology, climate, and hunting activity in this region over much of the Holocene. Aerial surveys have identified 72 ice patches of variable size, and 65 patches have been ground-surveyed for organic remains. Of these, 35 yielded an abundance of biological specimens, including caribou and other rare large mammal remains, mummified small mammals and birds, and artifacts spanning 8000 years. The dung provides pollen and plant macrofossils for analysis and paleoenvironmental reconstruction, as well as dietary, genetic, and parasitic information. Stratigraphically controlled sampling of dung within ice layers has yielded a geochronology placing their formation as early as 8300 to 8000 years BP. Ice patch formation was nearly continuous except for an interval between 6700 and 4700 years BP and another between 1440 and 1030, when warm or dry conditions (or both) resulted in no net ice accumulation. Resumption of ice accumulation over the following 500 years likely culminated in the Little Ice Age. The size of the ice patches during this period is made evident by a lichen-free zone that haloes each patch. More recently, interpretation of air photos from 1946 to 2001 has found a significant reduction in ice patch dimensions. Daily temperature records for Whitehorse (1942-2001) were used to calculate melting degree-day values that account for a large part of the variation in ice patch size, indicating that while considerable melting has likely occurred since the end of the Little Ice Age, the ice patches are highly sensitive to decadal changes in temperature.Depuis la découverte de plaques de glace alpines riches en excréments d'animaux dans le sud-ouest du Yukon en 1997, des études multidisciplinaires continues offrent une fenêtre unique sur la biologie, le climat et les activités de chasse de la région pendant presque toute la période de l'Holocène. À l'aide de relevés aériens, il a été possible d'identifier 72 plaques de glace de tailles différentes. Des relevés sur le terrain ont été effectués sur 65 de ces plaques pour récupérer des restes organiques, et 18 d'entre-elles ont révélé une abondance d'espèces biologiques et des restes de grands mammifères rares (y compris le caribou), des petits mammifères et des oiseaux momifiés, et des artéfacts datant jusqu'à 8000 ans. Les excréments d'animaux permettent d'analyser des macrofossiles de pollen et de plantes afin de faire une reconstruction paléoécologique, ainsi que d'obtenir des renseignements sur le régime alimentaire, la génétique et les parasites. À l'aide de la géochronologie, l'échantillonnage des excréments d'animaux contrôlé par stratigraphie a permis de dater la formation des excréments à aussi loin que 8300 à 8000 ans B.P. La formation des plaques de glace a été presque continue, à l'exception d'une période entre 6700 et 4700 ans B.P. et d'une autre entre 1440 et 1030, lorsque des conditions chaudes ou sèches ou les deux n'ont pas permis à la glace de s'accumuler. La reprise de l'accumulation de glace au cours des 500 dernières années a vraisemblablement provoqué le petit âge glaciaire. La taille des plaques de glace au cours de cette période est facilement calculable grâce aux zones sans lichen qui encerclent chaque plaque. Des études plus récentes de photos aériennes prises entre 1946 et 2001 ont permis de constater une réduction marquée de la taille des plaques de glace. Les données des températures quotidiennes de Whitehorse (de 1942 à 2001) ont été utilisées pour calculer la valeur du degré-jour de fonte qui est en grande partie responsable de la variation de la taille des plaques de glace. Ces données indiquent que même si le plus gros de la fonte s'est produit depuis la fin du petit âge glaciaire, les plaques de glace réagissent beaucoup aux changements de température décennaux

Ethnographic and Archaeological Investigations of Alpine Ice Patches in Southwest Yukon, Canada

Since the original 1997 discovery of ancient hunting implements in melting alpine ice patches of southern Yukon, approximately 146 well-preserved, organic artifacts have been recovered. Most of the artifacts, variously made of antler, bone, wood, and stone, represent complete or partial examples of throwing-dart (atlatl) and bow-and-arrow technology. Radiocarbon dates obtained thus far range from 8360 BP to 90 BP (uncalibrated). Our research indicates that in southern Yukon, throwing-dart technology persisted from at least 8360 BP to approximately 1250 BP, when it was abruptly replaced by bow-and-arrow technology. The collection has afforded archaeologists and First Nation researchers a unique opportunity to learn about past hunting technologies and practices and thus greatly improve our understanding of the enduring relationships between humans and caribou.Depuis la découverte en 1997 d'anciens objets de chasse dans les plaques de glace alpines du sud du Yukon, environ 146 artéfacts organiques bien conservés ont été récupérés. La plupart des artéfacts, faits de bois d'animal, d'os, de bois ou de pierre, représentent des exemples complets ou partiels de propulseur lance-javelins (atlatl) et d'une technologie axée sur l'utilisation d'arc et de flèches. La datation au radiocarbone varie de 8360 ans B.P. à 90 ans B.P. (non étalonné). Les recherches effectuées rélèvent que dans le sud-est du Yukon, la technologie reposant sur l'utilisation du lance-javelines a été en usage de 8360 ans B.P. au moins jusqu'à environ 1250 ans B.P., époque à laquelle elle fut soudain remplacé par la technologie reposant sur l'utilisation de l'ensemble arc et flèche. Grâce à cette collection, les archéologues et les chercheurs des premières nations ont pu en apprendre davantage sur les technologies et les méthodes de chasse utilisées à cette époque et ainsi améliorer leur compréhension des relations durables entre l'humain et le caribou

Effect of gut microbiome modulation on muscle function and cognition:the PROMOTe randomised controlled trial

Studies suggest that inducing gut microbiota changes may alter both musclephysiology and cognitive behaviour. Gut microbiota may play a role in bothanabolic resistance of older muscle, and cognition. In this placebo controlleddouble blinded randomised controlled trial of 36 twin pairs (72 individuals),aged ≥60, each twin pair are block randomised to receive either placebo orprebiotic daily for 12 weeks. Resistance exercise and branched chain aminoacid (BCAA) supplementation is prescribed to all participants. Outcomes arephysical function and cognition. The trial is carried out remotely using videovisits, online questionnaires and cognitive testing, and posting of equipmentand biological samples. The prebiotic supplement is well tolerated and resultsin a changed gut microbiome [e.g., increased relative Bifidobacterium abundance].There is no significant difference between prebiotic and placebo forthe primary outcome of chair rise time (β=0.579; 95% CI −1.080-2.239p = 0.494). The prebiotic improves cognition (factor score versus placebo(β = −0.482; 95% CI,−0.813, −0.141; p = 0.014)). Our results demonstrate thatcheap and readily available gut microbiome interventions may improve cognitionin our ageing population. We illustrate the feasibility of remotelydelivered trials for older people, which could reduce under-representation ofolder people in clinical trials. ClinicalTrials.gov registration: NCT04309292

Higher dietary protein intake is associated with sarcopenia in older British twins

BACKGROUND: Sarcopenia, characterised by an accelerated loss of skeletal muscle mass and function, is associated with negative outcomes. This study aimed to evaluate factors associated with skeletal muscle strength, mass and sarcopenia, particularly protein intake, and to assess whether shared twin characteristics are important. METHODS: This study utilised cross-sectional data from a study of community-dwelling twins aged ≥60 years. Multivariable logistic regression and between- and within-twin pair regression modelling were used. RESULTS: Participants (n = 3,302) were 89% female (n = 2,923), aged a mean of 72.1 (±7.3) years and composed of 858 (55%) monozygotic, 709 (45%) dizygotic twin pairs and 168 individual lone twins. Using optimal protein intake as the reference group (1.0-1.3 g/kg/day), there was no significant association between protein intake (neither high nor low) and low muscle strength, or between low protein intake and sarcopenia (odds ratio (OR) 0.7; 95% confidence interval (CI) 0.39-1.25; P = 0.229) in unadjusted models. High protein intake (>1.3 g/kg/day) was associated with low muscle mass (OR 1.76; 95% CI 1.39-2.24; P < 0.0001), while low protein intake was protective (OR 0.52; 95% CI 0.40-0.67; P < 0.0001). High protein intake was associated with sarcopenia (OR 2.04; 95% CI 1.21-3.44; P = 0.008), and this was robust to adjustment for demographic, anthropometric and dietary factors. The association between muscle strength and weight, body mass index, healthy eating index, protein intake and alpha diversity was not significantly influenced by shared twin factors, indicating greater amenability to interventions. CONCLUSIONS: High protein intake is associated with sarcopenia in a cohort of healthy older twins

Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels.

Saliva, as a biofluid, is inexpensive and non-invasive to obtain, and provides a vital tool to investigate oral health and its interaction with systemic health conditions. There is growing interest in salivary biomarkers for systemic diseases, notably cardiovascular disease. Whereas hundreds of genetic loci have been shown to be involved in the regulation of blood metabolites, leading to significant insights into the pathogenesis of complex human diseases, little is known about the impact of host genetics on salivary metabolites. Here we report the first genome-wide association study exploring 476 salivary metabolites in 1419 subjects from the TwinsUK cohort (discovery phase), followed by replication in the Study of Health in Pomerania (SHIP-2) cohort. A total of 14 distinct locus-metabolite associations were identified in the discovery phase, most of which were replicated in SHIP-2. While only a limited number of the loci that are known to regulate blood metabolites were also associated with salivary metabolites in our study, we identified several novel saliva-specific locus-metabolite associations, including associations for the AGMAT (with the metabolites 4-guanidinobutanoate and beta-guanidinopropanoate), ATP13A5 (with the metabolite creatinine) and DPYS (with the metabolites 3-ureidopropionate and 3-ureidoisobutyrate) loci. Our study suggests that there may be regulatory pathways of particular relevance to the salivary metabolome. In addition, some of our findings may have clinical significance, such as the utility of the pyrimidine (uracil) degradation metabolites in predicting 5-fluorouracil toxicity and the role of the agmatine pathway metabolites as biomarkers of oral health

Correction to:Yoghurt consumption is associated with changes in the composition of the human gut microbiome and metabolome (BMC Microbiology, (2022), 22, 1, (39), 10.1186/s12866-021-02364-2)

Following the publication of the original paper [1], there’s an error on the first name of one of the authors. Mureil Derrien should be Muriel Derrien. Correct name is shown in the author group section above. The original article has been corrected