2,786 research outputs found
Electrostatic considerations affecting the calculated HOMO-LUMO gap in protein molecules.
A detailed study of energy differences between the highest occupied and
lowest unoccupied molecular orbitals (HOMO-LUMO gaps) in protein systems and
water clusters is presented. Recent work questioning the applicability of
Kohn-Sham density-functional theory to proteins and large water clusters (E.
Rudberg, J. Phys.: Condens. Mat. 2012, 24, 072202) has demonstrated vanishing
HOMO-LUMO gaps for these systems, which is generally attributed to the
treatment of exchange in the functional used. The present work shows that the
vanishing gap is, in fact, an electrostatic artefact of the method used to
prepare the system. Practical solutions for ensuring the gap is maintained when
the system size is increased are demonstrated. This work has important
implications for the use of large-scale density-functional theory in
biomolecular systems, particularly in the simulation of photoemission, optical
absorption and electronic transport, all of which depend critically on
differences between energies of molecular orbitals.Comment: 13 pages, 4 figure
A clinical algorithm for wound biofilm identication
Broj publiciranih referenci koje ukazuju na prisutnost biofi lma u kroničnim ranama je u porastu. Sve je veći broj dokaza koji potvrđuju da biofilm značajno sudjeluje u nezacijeljivanju rane i u bakterijskim infekcijama. Iz navedenih razloga postavlja se pitanje nedostatka postupnika o dokazima prisutnosti biofilma u rani. Namjera je ovog rada specifi cirati vidljive dokaze i indirektno dati kliničke smjernice tretmana biofilma u rani, te predložiti određeni postupnik za olakšanje kliničkog
prepoznavanja biofi lma da bi se potom promijenilo ciljano liječenje vrijeda.Recognition of the existence of biofilm in chronic wounds is increasing among wound care practitioners, and a growing body of evidence indicates that biofilm contributes significantly to wound recalcitrance. While clinical guidelines regarding the involvement of biofilm in human bacterial infections have been proposed, there remains uncertainty and lack of guidance towards biofilm presence in wounds. The intention of this report is to collate knowledge and evidence of the visual and indirect clinical indicators of wound biofilm, and propose an algorithm designed to facilitate clinical recognition of biofilm and subsequent wound management practices
Dissipative production of a maximally entangled steady state
Entangled states are a key resource in fundamental quantum physics, quantum
cryp-tography, and quantum computation [1].To date, controlled unitary
interactions applied to a quantum system, so-called "quantum gates", have been
the most widely used method to deterministically create entanglement [2]. These
processes require high-fidelity state preparation as well as minimizing the
decoherence that inevitably arises from coupling between the system and the
environment and imperfect control of the system parameters. Here, on the
contrary, we combine unitary processes with engineered dissipation to
deterministically produce and stabilize an approximate Bell state of two
trapped-ion qubits independent of their initial state. While previous works
along this line involved the application of sequences of multiple
time-dependent gates [3] or generated entanglement of atomic ensembles
dissipatively but relied on a measurement record for steady-state entanglement
[4], we implement the process in a continuous time-independent fashion,
analogous to optical pumping of atomic states. By continuously driving the
system towards steady-state, the entanglement is stabilized even in the
presence of experimental noise and decoherence. Our demonstration of an
entangled steady state of two qubits represents a step towards dissipative
state engineering, dissipative quantum computation, and dissipative phase
transitions [5-7]. Following this approach, engineered coupling to the
environment may be applied to a broad range of experimental systems to achieve
desired quantum dynamics or steady states. Indeed, concurrently with this work,
an entangled steady state of two superconducting qubits was demonstrated using
dissipation [8].Comment: 25 pages, 5 figure
Autobiographical memory in adults with autism spectrum disorder: the role of depressed mood, rumination, working memory and theory of mind.
Autobiographical memory difficulties have been widely reported in adults with autism spectrum disorder (ASD). The aim of the current study was to explore the potential correlates of autobiographical memory performance (including depressed mood, rumination, working memory and theory of mind) in adults with ASD, relative to a group of typical adults matched for age, gender and IQ. Results demonstrated that the adults with ASD reported higher levels of depressed mood and rumination than the typical adults, and also received lower scores on measures of theory of mind and working memory. Correlational analysis suggested that theory of mind and working memory were associated with autobiographical memory performance in the adults with ASD, but no significant relationships were observed between autobiographical memory, depressed mood and rumination in this group. To explore these patterns further, two cases of adults with a dual diagnosis of ASD and depression are discussed. These participants present a profile in line with the idea that depressed mood and rumination do not have the same influence on autobiographical memory in adults with ASD as they do in typical adults
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