2,498 research outputs found
Electrostatic considerations affecting the calculated HOMO-LUMO gap in protein molecules.
A detailed study of energy differences between the highest occupied and
lowest unoccupied molecular orbitals (HOMO-LUMO gaps) in protein systems and
water clusters is presented. Recent work questioning the applicability of
Kohn-Sham density-functional theory to proteins and large water clusters (E.
Rudberg, J. Phys.: Condens. Mat. 2012, 24, 072202) has demonstrated vanishing
HOMO-LUMO gaps for these systems, which is generally attributed to the
treatment of exchange in the functional used. The present work shows that the
vanishing gap is, in fact, an electrostatic artefact of the method used to
prepare the system. Practical solutions for ensuring the gap is maintained when
the system size is increased are demonstrated. This work has important
implications for the use of large-scale density-functional theory in
biomolecular systems, particularly in the simulation of photoemission, optical
absorption and electronic transport, all of which depend critically on
differences between energies of molecular orbitals.Comment: 13 pages, 4 figure
Recommended from our members
Remembering the past and imagining the future in autism spectrum disorder
Recent research has revealed that episodic memory (remembering past experiences) and episodic future thinking (imagining future experiences) rely on the same underlying neuro-cognitive system. Consistent with this suggestion, individuals with autism spectrum disorder (ASD) have been shown to experience difficulties in both domains. In the present study, 18 adults with ASD and 18 typical adults performed sentence completion tasks assessing the ability to generate past and future events. Contrary to previous research findings, results demonstrated that adults with ASD performed at an equivalent level to typical adults when generating both past and future events; generating a higher number of specific events when recalling past (relative to simulating future) events, and a higher number of semantic associates when simulating future (relative to recalling past) events. Results are discussed with respect to methodological factors affecting task performance in ASD including the social nature of the research, the need to verbalise memories to the experimenter, and whether or not the specific memory request is explicit
Linear-scaling quantum Monte Carlo technique with non-orthogonal localized orbitals
We have reformulated the quantum Monte Carlo (QMC) technique so that a large part of the calculation scales linearly with the number of atoms. The reformulation is related to a recent alternative proposal for achieving linear-scaling QMC, based on maximally localized Wannier orbitals (MLWO), but has the advantage of greater simplicity. The technique we propose draws on methods recently developed for linear-scaling density functional theory. We report tests of the new technique on the insulator MgO, and show that its linear-scaling performance is somewhat better than that achieved by the MLWO approach. Implications for the application of QMC to large complex systems are pointed out
Recommended from our members
Understanding the Mind or Predicting Signal-Dependent Action? Performance of Children With and Without Autism on Analogues of the False-Belief Task
To evaluate the claim that correct performance on unexpected transfer false-belief tasks specifically involves mental-state understanding, two experiments were carried out with children with autism, intellectual disabilities, and typical development. In both experiments, children were given a standard unexpected transfer false-belief task and a mental-state-free, mechanical analogue task in which participants had to predict the destination of a train based on true or false signal information. In both experiments, performance on the mechanical task was found to correlate with that on the false-belief task for all groups of children. Logistic regression showed that performance on the mechanical analogue significantly predicted performance on the false-belief task even after accounting for the effects of verbal mental age. The findings are discussed in relation to possible common mechanisms underlying correct performance on the two tasks
O(N) methods in electronic structure calculations
Linear scaling methods, or O(N) methods, have computational and memory
requirements which scale linearly with the number of atoms in the system, N, in
contrast to standard approaches which scale with the cube of the number of
atoms. These methods, which rely on the short-ranged nature of electronic
structure, will allow accurate, ab initio simulations of systems of
unprecedented size. The theory behind the locality of electronic structure is
described and related to physical properties of systems to be modelled, along
with a survey of recent developments in real-space methods which are important
for efficient use of high performance computers. The linear scaling methods
proposed to date can be divided into seven different areas, and the
applicability, efficiency and advantages of the methods proposed in these areas
is then discussed. The applications of linear scaling methods, as well as the
implementations available as computer programs, are considered. Finally, the
prospects for and the challenges facing linear scaling methods are discussed.Comment: 85 pages, 15 figures, 488 references. Resubmitted to Rep. Prog. Phys
(small changes
Recommended from our members
ERP Correlates of Recognition Memory in Autism Spectrum Disorder
Recognition memory in autism spectrum disorder (ASD) tends to be undiminished compared to that of typically developing (TD) individuals (Bowler et al. 2007), but it is still unknown whether memory in ASD relies on qualitatively similar or different neurophysiology. We sought to explore the neural activity underlying recognition by employing the old/new word repetition event-related potential effect. Behavioural recognition performance was comparable across both groups, and demonstrated superior recognition for low frequency over high frequency words. However, the ASD group showed a parietal rather than anterior onset (300–500 ms), and diminished right frontal old/new effects (800–1500 ms) relative to TD individuals. This study shows that undiminished recognition performance results from a pattern of differing functional neurophysiology in ASD
Second Stage String Fragmentation Model
A string model, advocated by Bowler, provides a physical and intuitive
picture of heavy quark fragmentation. When supplemented by an ad hoc factor of
(1-z), to suppress fragmentation near z=1, it supplies an excellent fit to the
data. We extend Bowler's model by accounting for the further decay of the
massive mesonic states produced by the initial string breaking. We find that
each subsequent string break and cascade decay beyond the first, introduces a
factor of (1-z). Furthermore we find that including a finite mass for the
quarks, which pop out of the vacuum and split the string, forces the first
string breaking to produce massive states requiring further decay. This
sequence terminates at the second stage of fragmentation where only relatively
"light" heavy meson systems are formed. Thus we naturally account for the
phenomenologically required factor of (1-z). We also predict that the ratio of
(primary) fragments-vector/(vector plus scalar) should be .61. Our second stage
string fragmentation model provides an appealing picture of heavy quark
fragmentation.Comment: 15 page
- …