59 research outputs found
Mortalidade, anos potenciais de vida perdidos e incidência de acidentes de trabalho na Bahia, Brasil
Distribution and regulation of the optic nerve head tissue PO2
We investigated the distribution and regulation of the optic nerve head
(ONH) tissue partial pressure of oxygen (PO2) under various stimuli and
the role of the nitric oxide in the ONH circulation. Tissue PO2, was
measured using double-barreled recess microelectrodes in the intact eyes
of miniature pigs during normoxia, hyperoxia, hypoxia, variations of
systemic blood pressure, and after inhibition of the endothelial nitric
oxide synthesis by the administration of nitro-L-arginine. Measurements
were performed in front of the ONH at intervascular and juxta-arteriolar
areas and at a depth of 50 and 200 mu m within the ONH at the center and
tie rim. During normoxia, PO2 was heterogeneously distributed in the
ONH, higher close to the arterioles than in intervascular areas.
Hyperoxia induced a significant increase of juxta-arteriolar tissue PO2,
while ill intervascular-areas no change was noticed. Hypoxia did not
modify intervascular tissue PO2 at 200 mu m depth within the ONH.
Variations of the systemic blood pressure did not induce any significant
change in ONH tissue PO2,. Similarly, no modification was noticed after
the administration of nitro-L-arginine. There is a remarkable
autoregulatory capacity of the ONH circulation that may compensate for
parameters such as hyperoxia, hypoxia, and variations of the systemic
blood pressure. Endothelially derived nitric oxide inhibition does not
modify tie ONH tissue PO2, probably because the tissue PO2 is stabilized
by compensatory regulation. (C) 1997 by Elsevier Science Inc. All rights
reserved
Advice against smoking is not effective in patients with Graves' ophthalmopathy
Advice against smoking is one of the means frequently used in the
management of patients with Graves’ ophthalmopathy (GO). The objective
of this study was to prospectively evaluate the efficacy of such advice.
The study was performed at a referral centre. Eighty-five smokers out of
102 consecutive patients with GO, who were examined during a 1-year
period, were included in the study. Severity of the disease, smoking
history, and the results from a patients’ self-assessment questionnaire
were recorded.
The behavioural intervention consisted in a standardized 2-min message
from the attending ophthalmologist strongly advising each patient to
quit. The main outcome measure was smoking cessation during the 1-year
follow-up period. None of the 85 smokers reported smoking cessation
either during the follow-up visits or at the end point of the study.
The results of our study show that advice against smoking is not
effective among patients with GO. Specifically designed intervention
programmes may be necessary and should be evaluated in a controlled
trial
Hypothyroidism and glaucoma. A study of 100 hypothyroid patients
PURPOSE: To determine whether glaucoma is associated with
hypothyroidism, as has previously been suggested.
METHODS: This is a cross-sectional study and a noncomparative
interventional case series, One hundred consecutive patients with newly
diagnosed hypothyroidism were referred for complete ophthalmologic
examination, including automated perimetry and examination of the optic
disks, to identify the presence of glaucoma. After correction of the
hypothyroidism, reexamination was performed.
RESULTS: No patient had glaucoma and no correlation was found between
intraocular pressure and either thyroid stimulating hormone or free
tri-iodothyronine. No statistically significant difference was found
between intraocular pressure levels before and after treatment of the
hypothyroidism.
CONCLUSION: This study does not demonstrate an association between
hypothyroidism and glaucoma. (Am J Ophthalmol 2001;131:126-128. (C) 2001
by Elsevier Science Inc. All rights reserved.)
Sudden loss of visual acuity following intra-articular steroid injection in to the knee joint: a case report
Unintentional secondary exogenous corticosteroid exposure and central serous chorioretinopathy
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