49 research outputs found
A Study of the In-Service Education Programs Available to Elementary Principals in Spokane, Stevens and Whitman Counties
The purpose of this study was to ascertain the availability of in-service education programs to elementary principals in a selected geographical area, to determine who planned the programs, what types of programs were available and what areas of study were included in these programs
William E. Barry Correspondence
Entries include typed letters on personal stationery from Bourne presenting books to the Maine Author Collection, and specifically a book published by his executors, as a provision from Barry\u27s wil
Overview of the Alliance for Cellular Signaling
The Alliance for Cellular Signaling is a large-scale collaboration designed to answer global questions about signalling networks. Pathways will be studied intensively in two cells-B lymphocytes (the cells of the immune system) and cardiac myocytes-to facilitate quantitative modelling. One goal is to catalyse complementary research in individual laboratories; to facilitate this, all alliance data are freely available for use by the entire research community.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62977/1/nature01304.pd
Genetics ignite focus on microglial inflammation in Alzheimer’s disease
In the past five years, a series of large-scale genetic studies have revealed novel risk factors for Alzheimer’s disease (AD). Analyses of these risk factors have focused attention upon the role of immune processes in AD, specifically microglial function. In this review, we discuss interpretation of genetic studies.  We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE. We review the literature regarding the biological functions of these six proteins and their putative role in AD pathogenesis. We then present a model for how these factors may interact to modulate microglial function in AD