101 research outputs found

    Multiple cardiovascular comorbidities and acute myocardial infarction: temporal trends (1990–2007) and impact on death rates at 30 days and 1 year

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    BACKGROUND: The objectives of this community-based study were to examine the overall and changing (1990-2007) frequency and impact on 30-day and 1-year death rates from multiple cardiovascular comorbidities in adults from a large central New England metropolitan area hospitalized with acute myocardial infarction (AMI). METHODS: The study population consisted of 9581 patients hospitalized with AMI at all 11 medical centers in the metropolitan area of Worcester, MA, during 10 annual periods between 1990 and 2007. The comorbidities examined included atrial fibrillation, diabetes, heart failure, hypertension, and stroke. RESULTS: Thirty-five percent of participants had a single diagnosed cardiovascular comorbidity, 25% had two, 12% had three, and 5% had four or more comorbidities. Between 1990 and 2007, the proportion of patients without any of these comorbidities decreased significantly, while the proportion of patients with multiple comorbidities increased significantly during the years under study. An increasing number of comorbidities was associated with higher 30-day and 1-year postadmission death rates in patients hospitalized with AMI. CONCLUSION: Patients hospitalized with AMI carry a significant burden of comorbid cardiovascular disease that adversely impacts their 30-day and longer-term survival. Increased attention to the management of AMI patients with multiple cardiovascular comorbidities is warranted

    On the predominant mechanisms active during the high power diode laser modification of the wettability characteristics of an SiO2/Al2O3-based ceramic material

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    The mechanisms responsible for modifications to the wettability characteristics of a SiO2/Al2O3-based ceramic material in terms of a test liquid set comprising of human blood, human blood plasma, glycerol and 4-octonol after high power diode laser (HPDL) treatment have been elucidated. Changes in the contact angle, , and hence the wettability characteristics of the SiO2/Al2O3-based ceramic were attributed primarily to: modifications to the surface roughness of the ceramic resulting from HPDL interaction which accordingly effected reductions in ; the increase in the surface O2 content of the ceramic after HPDL treatment; since an increase in surface O2 content intrinsically brings about a decrease in , and vice versa and the increase in the polar component of the surface energy, due to the HPDL induced surface melting and resolidification which consequently created a partially vitrified microstructure that was seen to augment the wetting action. However, the degree of influence exerted by each mechanism was found to differ markedly. Isolation of each of these mechanisms permitted the magnitude of their influence to be qualitatively determined. Surface energy, by way of microstructural changes, was found to be by far the most predominant element governing the wetting characteristics of the SiO2/Al2O3-based ceramic. To a much lesser extent, surface O2 content, by way of process gas, was also seen to influence to a changes in the wettability characteristics of the SiO2/Al2O3-based ceramic, whilst surface roughness was found to play a minor role in inducing changes in the wettability characteristics

    Direct Selective Laser Sintering of High Temperature Materials

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    Abstract Selective Laser Sintering (SLS) involving a coexisting liquid and particulate solid during the SLS processing can be used to produce freeform parts directly with high temperature materials. Factors such as scanning laser power density, residence time, scan line spacing, the interfacial energies between the liquid and solid phases, powder bed biasing temperature, and sintering atmosphere greatly affect the microstructure evolution in the SLS process. Direct SLS of high melting temperature mixed powder materials was demonstrated using a 1.1 kW C02 laser SLS system. The relationship between the microstructures and the process parameters will be described

    Spatially resolved acoustic spectroscopy for rapid imaging of material microstructure and grain orientation

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    Measuring the grain structure of aerospace materials is very important to understand their mechanical properties and in-service performance. Spatially resolved acoustic spectroscopy is an acoustic technique utilizing surface acoustic waves to map the grain structure of a material. When combined with measurements in multiple acoustic propagation directions, the grain orientation can be obtained by fitting the velocity surface to a model. The new instrument presented here can take thousands of acoustic velocity measurements per second. The spatial and velocity resolution can be adjusted by simple modification to the system; this is discussed in detail by comparison of theoretical expectations with experimental data
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